Results 71 to 80 of about 17,595 (163)

Intermittent Hypoxia Exacerbates Lipopolysaccharide‐Induced Neurobehavioral Abnormalities: The Role of Neuroinflammation and Synaptic‐Related Proteins

Brain and Behavior, Volume 16, Issue 8, August 2026.
ABSTRACT Background Sepsis is a common systemic inflammatory disease clinically observed in patients with severe trauma or infectious diseases. Lipopolysaccharide (LPS) serves as a classic tool for studying infection‐related neuroinflammation and behavioral changes.
Yi‐Zhu Ding, Zong‐Fang Wang, Chen Dai, Yuan‐Zi Ye   +3 more
wiley   +1 more source

Intermittent hypobaric hypoxia and neuroendocrine reaction of the parvocellular neurons of the paraventricular hypothalamic nucleus

Patologìâ, 2019
The neuroendocrine system occupies an important place in the systemic mechanisms of the body response to stress. The paraventricular nuclei of the hypothalamus (PVH) are one of the most important links of the brain`s neuroendocrine system which determine
V. O. Shamenko, Ye. V. Kadzharian, A. V. Abramov   +2 more
doaj   +1 more source

Intermittent Hypobaric Hypoxia Promotes Atherosclerotic Plaque Instability in ApoE-Deficient Mice [PDF]

High Altitude Medicine & Biology, 2013
Sudden cardiac death is one of the most frequent causes of death at high altitude. It has been reported that the intermittent normobaric hypoxia experienced by patients with obstructive sleep apnea may enhance the development of atherosclerosis. However, the effect of hypobaric hypoxia, which mimics the ambient air at high altitude, in the development ...
Sihua, Jiang, Feipeng, Jin, De, Li, Xingmei, Zhang, Yun, Yang, Dachun, Yang, Kun, Li, Yongjian, Yang, Shuangtao, Ma   +8 more
openaire   +2 more sources

Jumping in simulated lunar gravity with blood flow restriction as a potential exercise countermeasure: The acute physiological effects

Experimental Physiology, Volume 111, Issue 8, Page 3699-3717, 1 August 2026.
Abstract The present study examined the cardiovascular, metabolic, neuromuscular and perceptual effects of low‐intensity jumping in simulated lunar gravity (∼20% bodyweight) with blood flow restriction (BFR). Fourteen healthy adults (24 ± 4 years; 1.81 ± 0.06 m; 75 ± 12 kg) completed an incremental jumping test in simulated lunar gravity (9.5° head‐up ...
Patrick Swain, Filipa Santos, Nick Caplan, Cody Latue, Billie Illingworth, Nicky Sheard, Luke Hughes   +6 more
wiley   +1 more source

The effects of chronic long-term intermittent hypobaric hypoxia on blood rheology parameters

General physiology and biophysics, 2012
The effect of chronic long-term intermittent hypobaric hypoxia (CLTIHH) on blood rheology is not completely investigated. We designed this study to determine the effect of CLTIHH on blood rheology parameters. Present study was performed in 16 male Spraque-Dawley rats that divided into CLTIHH and Control groups.
Yelmen, Nermin, Ozdemir, Semra, Guner, Ibrahim, Toplan, Selmin, Sahin, Gulderen, Yaman, Onur M., Sipahi, Sevtap   +6 more
openaire   +3 more sources

High‐Altitude Hypoxia Activates JNK‐p53 Signaling: Linking Hippocampal Energy Crisis to Cognitive Impairment

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Chronic high‐altitude hypoxia impairs memory in 2819 residents and causes hippocampal atrophy in rats. JNK‐p53‐Bim signaling drives mitophagy‐to‐apoptosis transition and 73% ATP depletion, while concurrent HIF‐2α/PHD2 activation indicates parallel adaptive responses.
Guisheng Hao, Zhengzhong Bai, Wenjuan Wang, Jian Wu, Fan Zheng, Guoen Jin, Ri‐Li Ge   +6 more
wiley   +1 more source

Hypobaric hypoxia-related impairment of pulmonary surfactant proteins A and D did not favour Pneumocystis carinii Frenkel 1999 growth in non-immunocompromised rats

Parasite, 2008
It has been suggested that patients with pulmonary surfactant impairment are more susceptible to Pneumocystis infection than healthy controls. Owing the fact that most patients with pulmonary surfactant impairment also suffer from hypoxia, we explored ...
Vives M.F., Caspar-Bauguil S., Aliouat E.M., Escamilla R., Perret B., Dei-Cas E., Prévost M.C.   +6 more
doaj   +1 more source

Neuroprotective effects of intermittent hypobaric hypoxia in rats: caspase-3, NT-3, SOD, and carbonyl profiles

Damianus: Journal of Medicine
Introduction: The brain is the largest energy-consuming organ in the body and is highly vulnerable to damage under hypoxic conditions. However, certain periods of hypoxia can be tolerated and provide protective effects.
Ninik Mudjihartini, Defli Yuandika Ruso, W. Mulyawan, A. C. Barasila, Yulhasri   +4 more
semanticscholar   +1 more source

Sympatho‐Excitation in Pulmonary Hypertension: The Potential Role of Pulmonary Arterial Baroreceptors: An Acute Physiologic Intervention Study

Respirology, Volume 31, Issue 6, Page 621-629, June 2026.
Pulmonary arterial baroreceptors reflexively stimulate sympathetic nerve activity (SNA) in response to elevated pulmonary artery pressure and distension. In pulmonary hypertension patients, changes in muscle SNA were proportional to changes in pulmonary haemodynamics following nebulised iloprost.
Michael J. Plunkett, Ana L. C. Sayegh, Robert A. Lewis, Tanya J. McWilliams, Sasiharan Sithamparanathan, Julian F. R. Paton, James P. Fisher   +6 more
wiley   +1 more source

Altitude-Associated Central Apnea in Continuous Positive Airway Pressure Therapy

Sleep Science
Introduction At high altitudes, hypobaric hypoxia leads to central apneas in both healthy adults and patients with obstructive sleep apnea. This condition correlates with intermittent desaturation and disruption of sleep.
Gustavo Adolfo Gaitan Quintero, Leidy Paola Prada Romero, Ana María González, María Angélica Bazurto-Zapata   +3 more
doaj   +1 more source