Results 81 to 90 of about 17,595 (163)

The Protective Effects of Chronic Intermittent Hypobaric Hypoxia Against Osteoarthritis in Rats - Role of Nitric Oxide

, 2021
The study explored the effect of chronic intermittent hypobaric hypoxia (CIHH) on osteoarthritis (OA). CIHH conditioning was realized by exposing rats to hypobaric hypoxia environment mimicking 5,000 m high-altitude (PB=404 mmHg, PO2=84 mmHg) 6 h per ...
Tianci Wang, Dong Ren, Yun‐shan Su, Jian Lu, Ming Li, Yufeng Chen, Pengcheng Wang   +6 more
semanticscholar   +1 more source

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Hematologic response to four weeks of intermittent hypobaric hypoxia in highly trained athletes

Haematologica, 2005
Resume We investigated changes induced by four weeks of intermittent hypobaric hypoxia (IHH) at a simulated altitude of 4000-5500 m in highly trained athletes.
Abellan, Rosario, Remacha, Angel Francisco, Ventura, Rosa, Sarda, M Pilar, Segura, Jordi, Rodriguez, Ferran A.   +5 more
openaire   +3 more sources

Cellular Signalling Networks in High Altitude Pulmonary Hypertension: From Canonical Pathways to Emerging Targets

Cell Proliferation, Volume 59, Issue 4, April 2026.
This review elucidates the intricate cellular signalling networks involved in high‐altitude pulmonary hypertension (HAPH), integrating canonical pathways like HIF, MAPK and BMP with emerging targets such as Wnt/β‐catenin, Notch, Hippo‐YAP and IL‐6. It highlights potential therapeutic strategies targeting these pathways to mitigate vascular remodelling ...
Sheng Ding, Ju Chen, Zhaoyang Li, Yang Yu, Weijie Wang, Yan Liao, Jin Yang, Dianxiang Lu, Yujiang Fan   +8 more
wiley   +1 more source

The influence of hypoxia and prolonged exercise on attentional performance at high and extreme altitudes: A pilot study. [PDF]

PLoS ONE, 2018
INTRODUCTION:Exposure to hypoxic conditions is reported to impair cognitive performance. Further, moderate physical exercise improves cognitive function, but little is known about the influence of exercise on cognitive function in hypoxia. Therefore, the
Mirjam Limmer, Petra Platen
doaj   +1 more source

Effect of live‐high, train‐low strategy induced by chronic low‐dose carbon monoxide exposure on haematological parameters and performance in trained individuals

Experimental Physiology, Volume 111, Issue 4, Page 1891-1903, 1 April 2026.
Abstract Altitude training enhances haematological adaptations and endurance at sea level, typically requiring exposure to ∼2500 m altitude for 3–4 weeks. Emerging evidence suggests that low‐dose carbon monoxide (CO) inhalation might mimic hypoxia and might be used by elite athletes.
Simone Villanova, Simone Porcelli, Lena Ekström, Daniele A. Cardinale   +3 more
wiley   +1 more source

Effects of hypoxic training interventions on cardiometabolic health of adults with overweight and obesity: A systematic review and meta‐analysis

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 865-877, February 2026.
Abstract Obesity rates have surpassed underweight globally, increasing the burden of cardiometabolic complications on healthcare systems. Hypoxic training has emerged as a potential intervention to improve cardiometabolic health in adults with obesity, but evidence remains inconclusive. This systematic review and meta‐analysis evaluated whether hypoxic
Alessandro Gatti, Caterina Cavallo, Matteo Giuriato, Agnese Pirazzi, Vittoria Carnevale Pellino, Nicola Lovecchio, Stefano Lazzer, Virginia Rossi, Valeria Calcaterra, Gianvincenzo Zuccotti, Anna Odone, Alba Camacho‐Cardenosa, Matteo Vandoni   +12 more
wiley   +1 more source

Melatonin Protects the Heart, Lungs and Kidneys from Oxidative Stress under Intermittent Hypobaric Hypoxia in Rats

Biological Research, 2012
Melatonin (N-acetyl-5-methoxytryptamine) is the main secretory product of the pineal gland in all mammals including humans, but it is also produced in other organs.
Jorge G Farías, Andrea B Zepeda, Gloria M Calaf   +2 more
doaj  

Effect of moderate altitude and nocturnal oxygen therapy on cerebrovascular function in patients with COPD: A randomized, crossover trial at 2048 m

Experimental Physiology, Volume 111, Issue 2, Page 527-538, 1 February 2026.
Abstract We investigated whether nocturnal oxygen therapy improves next‐day cerebrovascular function in lowlanders with chronic obstructive pulmonary disease (COPD) staying at moderate altitude. This randomized, placebo‐controlled single‐blind crossover trial was performed in moderate‐to‐severe COPD patients [forced expiratory volume in 1 s (FEV1 ...
Dominic Gilliand, Tsogyal D. Latshang, Sayaka S. Aeschbacher, Fabienne Huber, Deborah Flueck, Mona Lichtblau, Stefanie Ulrich, Elisabeth D. Hasler, Philipp M. Scheiwiller, Julian Müller, Silvia Ulrich, Konrad E. Bloch, Michael Furian   +12 more
wiley   +1 more source

Facilitation of Chronic Intermittent Hypobaric Hypoxia on Carotid Sinus Baroreflex in Anesthetized Rats

The Chinese Journal of Physiology, 2012
Our previous study showed that chronic intermittent hypobaric hypoxia (CIHH) could prevent decreases in systemic arterial blood pressure (SABP) during acute hypoxia. However, the mechanism was not clear. The purpose of the present study was to observe whether the carotid sinus baroreflex (CSB) was involved in the antagonizing effect of CIHH on SABP ...
Lu, Gao, Yue, Guan, Fang, Cui, Yi-Xian, Liu, Zhao-Nian, Zhou, Yi, Zhang   +5 more
openaire   +2 more sources