Results 61 to 70 of about 17,595 (163)

Intermittent hypoxia hypobaric exposure minimized oxidative stress and antioxidants in brain cells of Sprague Dawleymice

Health Science Journal of Indonesia, 2013
AbstrakLatar belakang: Hipoksia hypobaric meningkatkan produksi radikal bebas, terutama spesies oksigen reaktif (ROS). Peningkatan ROS akan menyebabkan stres oksidatif bila tidak disertai dengan peningkatan enzim antioksidan.
Wardaya Wardaya, Wawan Mulyawan, Minarma Siagian   +2 more
doaj   +3 more sources

Brain strain: Blood flow and metabolism in environmental extremes

Experimental Physiology, EarlyView.
Abstract This narrative review compares and contrasts the most commonly encountered environmental stressors on human cerebrovascular functioning. From high altitude and space, extreme apnoea, heat and cold stress, the impact of these stressors on the regulation of cerebral blood flow (CBF) and oxygen metabolism (CMRO2${\mathrm{CM}}{{\mathrm{R}}_ ...
Dario Vrdoljak, Damian M. Bailey, Travis D. Gibbons, Philip N. Ainslie   +3 more
wiley   +1 more source

Neuromuscular fatigability with repeated exercise in hypoxia: From single‐joint paradigms to sprints

The Journal of Physiology, EarlyView.
Abstract figure legend Acute hypobaric or normobaric hypoxic exposure accelerates neuromuscular fatigability during repeated exercise. Indices of peripheral and central fatigue are not different at exhaustion in mild, moderate and severe hypoxia compared with normoxia, but task failure occurs earlier.
Luca Ruggiero, Franck Brocherie, Olivier Girard, Nathan Townsend, Chris J. McNeil, Grégoire P. Millet   +5 more
wiley   +1 more source

Intermittent Exposure to Hypobaric Hypoxia Increases VEGF, HIF-1α, and Nrf-2 Expressions in Brain Tissue

Indonesian Biomedical Journal
BACKGROUND: Hypoxia inducible factor-1α (HIF-1α), nuclear factor erythroid 2-related factor 2 (Nrf-2), and vascular endothelial growth factor (VEGF), play a crucial role as neuroprotective factors.
Wardaya Wardaya, Dewi Sukmawati, Nurhadi Ibrahim, Frans Ferdinal, Ninik Mudjihartini, Mohamad Sadikin, Sri Widia A. Jusman, Irawan Satriotomo, Wawan Mulyawan   +8 more
doaj   +1 more source

Effects of nocturnal periodic breathing on sympathetic nerve activity and ventilatory control at high altitude: a randomised, crossover study

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the randomised crossover study investigating the effects of nocturnal periodic breathing (nPB) on sympathetic activity and ventilatory acclimatisation in hypobaric hypoxia equivalent to 4000 m altitude. Participants completed two 3‐day sojourns where nPB was inhibited by increasing inspiratory CO2 fraction ...
Johanna Roche, James P. Fisher, Peter Rasmussen, Abubaker Ibrahim, Philip N. Ainslie, Rachel Turner, Giovanni Vinetti, Matteo Cesari, Michael Furian, Ambra Stefani, Nikolaus Netzer, Hannes Gatterer, Birgit Högl, Christoph Siebenmann   +13 more
wiley   +1 more source

Hypobaric hypoxia exposure regulates tissue distribution of nanomedicine for enhanced cancer therapy

Cancer Nanotechnology
Background Effective drug delivery of nanomedicines to targeted sites remains challenging. Given that hypobaric hypoxia and hyperbaric oxygen exposure can significantly change pharmacokinetics of drugs, it is interesting to determine whether they can ...
Ye Tao, Zhongping Chen
doaj   +1 more source

Lower Body Weight in Rats Under Hypobaric Hypoxia Exposure Would Lead to Reduced Right Ventricular Hypertrophy and Increased AMPK Activation

Frontiers in Physiology, 2020
BackgroundBoth chronic hypoxia (CH) and long-term chronic intermittent hypoxia (CIH) exposure lead to right ventricular hypertrophy (RVH). Weight loss is an effective intervention to improve cardiac function and energy metabolism in cardiac hypertrophy ...
Karen Flores, Karen Flores, Patricia Siques, Patricia Siques, Julio Brito, Julio Brito, Stefany Ordenes, Stefany Ordenes, Karem Arriaza, Karem Arriaza, E. Pena, E. Pena, Fabiola León-Velarde, Rosario López, Ángel L. López de Pablo, Silvia Arribas   +15 more
doaj   +1 more source

Chronic intermittent hypobaric hypoxia attenuates ischemic limb injury by promoting angiogenesis in mice.

Canadian Journal of Physiology and Pharmacology, 2021
This study aimed to evaluate the protective effect of chronic intermittent hypobaric hypoxia (CIHH) against limb ischemic injury. C57BL/6 mice were randomly divided into three groups: limb ischemic injury group (Ischemia, induced by ligation and excision
Yan-Ming Tian, Li Zhang, Xinqi Guo, Zhimin Gao, Zhang Yi, Liping Zhang, Z. Hou   +6 more
semanticscholar   +1 more source

PGC-1α Participates in the Protective Effect of Chronic Intermittent Hypobaric Hypoxia on Cardiomyocytes [PDF]

Cellular Physiology and Biochemistry, 2018
Background/Aims: Myocardial ischemia/reperfusion (I/R) or hypoxia/reoxygenation (H/R) injury is always characterized by Ca2+ overload, energy metabolism disorder and necrocytosis of cardiomyocytes. We showed previously that chronic intermittent hypobaric hypoxia (CIHH) improves cardiac function during I/R through improving cardiac glucose metabolism ...
Shuo Gu, Hong Hua, Xinqi Guo, Zhanfeng Jia, Yi Zhang, Leonid N. Maslov, Xiangjian Zhang, Huijie  Ma   +7 more
openaire   +3 more sources

Reduced cardiovascular mortality at moderate altitude: a putative role of physical activity and body mass

The Journal of Physiology, EarlyView.
Abstract figure legend Benefits of performing physical exercise at moderate altitude. At moderate altitude, increased resting metabolic rate and physical exertion promote physical fitness and exercise tolerance, whereas hypoxia suppresses appetite and elicits adaptations that increase tissue O2 delivery while augmenting O2‐independent ATP production ...
Robert T. Mallet, Johannes Burtscher, Hannes Gatterer, Katharina Hüfner, Samuel Verges, Tadej Debevec, Martin Burtscher   +6 more
wiley   +1 more source