Results 101 to 110 of about 8,905 (245)

Should We Swap Internal Foundations for Virtues?

open access: yesCrítica, 2019
Internalist foundationalism was popular through much of the history of Western epistemology, but has been subjected to intense critical scrutiny in the last century.
Ram Neta
doaj   +1 more source

Scratching the structure of moral agency: insights from philosophy applied to neuroscience. [PDF]

open access: yesFront Neurosci, 2023
Castro-Toledo FJ   +2 more
europepmc   +1 more source

The Phenomenal Conservative Approach to Religious Epistemology [PDF]

open access: yes, 2020
In this chapter, we argue for a phenomenal conservative perspective on religious epistemology and attempt to answer some common criticisms of this ...
Gage, Logan Paul, McAllister, Blake
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Minimalist Meaning, Internalist Interpretation

open access: yesBiolinguistics, 2008
This article offers a conception of semantics, and of what makes the human language faculty distinctive, based on five theses: Meanings are instructions to build concepts; concatenation calls for conjunction of monadic concepts; grammatical relations ...
Paul M. Pietroski
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Phenomenal Conservatism and the Internalist Intuition [PDF]

open access: yes, 2006
Externalist theories of justification create the possibility of cases in which everything appears to one relevantly similar with respect to two propositions, yet one proposition is justified while the other is not.
Huemer, Michael
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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