Results 161 to 170 of about 31,667 (251)

From Balance to Breakdown: striatal PV interneurons in Huntington's disease and Autism Spectrum Disorder. [PDF]

Front Cell Neurosci
Thabault M, Galvan L.
europepmc   +1 more source

Maturation of spinal motor control through developmental changes in ion currents

The Journal of Physiology, EarlyView.
Abstract figure legend Ion channels of spinal neurons have been shown to change during development in a wide range of species. These changes occur at specific stages of development. An important developmental process is the maturation of motor control by which the body acquires new movements or refines movements already present.
Stephanie F. Gaudreau, Tuan V. Bui
wiley   +1 more source

Delayed forebrain excitatory and inhibitory neurogenesis in STRADA-related megalencephaly via mTOR hyperactivity. [PDF]

Stem Cell Reports
Pan T, Lin G, Li X, VanHeyningen D, Walker JC, Kohli S, Saravanan A, Kondur A, Jaklic DC, Pantoja-Gutierrez S, Vaid S, Sturza J, Inoki K, Imamichi T, Chang W, Dang LT.   +15 more
europepmc   +1 more source

Organization of Astrocytic GLT‐1 at Cortical Inhibitory Synapses

Glia, Volume 74, Issue 8, August 2026.
GLT‐1+ ALs frequently juxtapose symmetric synapses. Distance‐based phenotyping identifies symmetric‐ and asymmetric‐associated GLT‐1+ ALs. Distal inhibitory synapses show enriched GLT‐1/α2 couples in ALs within 1000 nm, conserved in human cortex. ABSTRACT Glutamate spillover from excitatory synapses modulates neighboring inhibitory synapses, yet the ...
Marcello Melone, Michael Di Palma, Annalisa Scimemi, Fiorenzo Conti   +3 more
wiley   +1 more source

Metabolic Assessment in Human Pluripotent Stem Cell‐Derived Cerebral Organoids Using HR‐MAS NMR Spectroscopy

NMR in Biomedicine, Volume 39, Issue 8, August 2026.
We present a direct method for evaluating metabolism in intact hPSC‐derived cerebral organoids (COs) via HR‐MAS 1H‐NMR spectroscopy. This approach suggests that COs exhibit a metabolic profile similar to in vivo human fetal brain, with high levels of lactate and hTau, low levels of NAA, and equimolar levels of Glu and Gln.
Maria Alejandra Castilla Bolanos, Vorapin Chinchalongporn, Rajshree Ghosh Biswas, Colleen Bailey, Maggie Wu, Ronald Soong, Fermisk Saleh, Andre Simpson, Carol Schuurmans, Jamie Near   +9 more
wiley   +1 more source

Heterogeneity of ictal firing during generalized seizures in the awake cortex. [PDF]

Cereb Cortex
Sere P, Nagy O, Zsigri N, Crunelli V, Lőrincz ML.   +4 more
europepmc   +1 more source

Pharmacokinetics and pharmacodynamics of intravenous and oral (S)‐ketamine: Investigating metabolite contribution to subjective effects

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2260-2271, July 2026.
Aims Oral administration of (S)‐ketamine for treatment‐resistant depression (TRD), as alternative to the registered intranasal or off‐label intravenous administrations, has high potential. However, it is characterized by an extensive first‐pass metabolism, resulting in low (S)‐ketamine exposure and high levels of active metabolites, including (S ...
Marije E. Otto, Gabriël E. Jacobs, Joost C. van Mechelen, Laura G. J. M. Borghans, Johan G. C. van Hasselt, Linda B. S. Aulin   +5 more
wiley   +1 more source

The role of sensory experience in the maturation of prefrontal cortical circuits. [PDF]

Front Neurosci
Anqueira-González A, Canetta S.
europepmc   +1 more source

Neurodevelopmental Consequences Induced by Early‐Life Lead Exposure Through Disruption of Neurotransmitter Pathways and Molecular Mechanisms: A Systematic Review

Developmental Neurobiology, Volume 86, Issue 3, July 2026.
ABSTRACT Lead is a toxic heavy metal with significant health risks, as maternal lead exposure during pregnancy disrupts fetal neural development through placental transfer, leading to persistent neurological, developmental, and long‐term health consequences in the progeny.
P. Harshitha, Aluru Parithathvi, Kamalesh Dattaram Mumbrekar, Herman Sunil Dsouza   +3 more
wiley   +1 more source

From Efference Copy to Emotional State: Insular Cortex Somatostatin Neurons Buffer Adaptive Responses to Physical Stress. [PDF]

Biol Psychiatry Glob Open Sci
Joffe ME.
europepmc   +1 more source