Results 231 to 240 of about 57,607 (282)

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, Sung Joong Lee   +10 more
wiley   +1 more source

Parvalbumin interneurons drive depth-dependent vascular responses. [PDF]

iScience
Rakymzhan A, Fukuda M, Anaya FJ, Fish KN, Kozai TDY, Vazquez AL.   +5 more
europepmc   +1 more source

Catheter Ablation for Frequent Premature Ventricular Contractions or Paroxysmal Supraventricular Tachycardia With Vagal Bradycardia: A New Clinical Application of Superior Vena Cava–Aorta Ganglionated Plexus Modification

Clinical Cardiology, Volume 49, Issue 4, April 2026.
This study demonstrates that combined RFCA and right atrial Ao‐SVC GP ablation provides a one‐stop, innovative solution for patients with vagal bradycardia and concomitant tachyarrhythmias, significantly improving symptoms and reducing syncope. ABSTRACT Background Frequent premature ventricular contractions (PVCs) or paroxysmal supraventricular ...
Xinai Meng, Senlin Huang, Liwei He, Tian Liu, Yanjia Chen, Huahua Li, Xingfu Huang   +6 more
wiley   +1 more source

Selective Lis1 inactivation disrupts migration and positioning of cortical somatostatin interneurons. [PDF]

Sci Rep
Pombero A, García-López R, Geijo-Barrientos E, Martínez S.   +3 more
europepmc   +1 more source

Dopaminergic Innervation of the Nidopallium Caudolaterale in the Japanese Quail

Journal of Comparative Neurology, Volume 534, Issue 4, April 2026.
The nidopallium caudolaterale (NCL) of the Japanese quail was delineated based on quantitative TH+ fiber density, identifying it as the primary dopaminergic target within the pallium. TH+ basket‐like structures predominantly surrounded CaMKIIa+ excitatory neurons, with sparse contacts onto GABAergic interneurons.
Defne Albayrak, Sinem Gencturk, Kevin B. Haselhuhn, Cem Sevinc, Onur Güntürkün, Mehdi Behroozi, Noemi Rook, Gunes Unal   +7 more
wiley   +1 more source

Human chorionic gonadotropin decreases cerebral cystic encephalomalacia and parvalbumin interneuron degeneration in a pro-inflammatory model of mouse neonatal hypoxia-ischemia. [PDF]

Sci Rep
Miller B, Crider A, Aravamuthan B, Galindo R.   +3 more
europepmc   +1 more source

Activation of GPR35 in the Anterior Cingulate Cortex Alleviates Neuropathic Pain and Depression‐Related Behavior

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
Sciatic nerve injury led to a significant increase in the expression of GPR35 in the ACC region of mice. This increased interaction with Nr4a1 can activate the PI3K/AKT signaling pathway, thereby reducing neuroinflammation and playing a role in alleviating hyperalgesia and depressive behavior in mice. ACC, anterior cingulate cortex.
Jianling Xu, Jingyong Zhou, Xiaojun Li, Tingting Qu, Changjian Zheng, Qingyu Cheng, Xiuyang Lei, Weidong Yao, Yongquan Chen, Bin Wang   +9 more
wiley   +1 more source

Ameliorating Seizures in Dravet Syndrome: A Review of Newly Approved and Investigational Drugs, RNA and Gene-Based Therapies. [PDF]

CNS Drugs
Balestrini S, Scheffer IE.
europepmc   +1 more source

GABAergic Neuron Activation in the RMTg‐VTA Pathway Modulates Dopaminergic Neuron Excitability and Social Stress Susceptibility in Male Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
In susceptible mice, dopamine neurons in the VTA exhibit increased excitability along with upregulation of GABAA receptors. Administration of the GABAA receptor agonist muscimol reduces this neuronal hyperexcitability and reverses social avoidance behavior.
Guang‐Yue Ma, Jin‐Zhu Zhuang, Shu‐Feng Li, Yu‐E Zhang, Di Zhang, Jun Zhao, Zhen Peng, Liu Yang, Zhang Cao, Xin Xie, Rong Jiang, Hui Sun   +11 more
wiley   +1 more source

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu, Alex Liang, Benjamin U. Hoffman, Dawn M. Schiehser, Oliver Case, Alan Simmons, Ruth Klaming, Andres Gottfried‐Blackmore, Ravinder K. Mittal, Christopher Puleo, Hubert Lim, Imanuel Lerman   +11 more
wiley   +1 more source