Results 41 to 50 of about 1,636,264 (261)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Evaluation of reports received on a digital platform for monitoring and self-care of individuals facing the COVID-19 pandemic in Brazil: Contributions to public health

Clinical Epidemiology and Global Health
Objectives: To evaluate the contribution of the digital platform “Meu Diário de Quarentena (MDQ)'' or My Quarantine Diary concerning the monitoring and self-care of individuals with COVID-19 in Brazil.
Luiz Ricardo Albano dos Santos, Luana Michelly Aparecida Costa dos Santos, Guilherme José Aguilar, Wilbert Dener Lemos Costa, Dantony de Castro Barros Donato, Valdes Roberto Bollela, Alan Maicon de Oliveira   +6 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Intersectional Strategies for Targeting Amacrine and Ganglion Cell Types in the Mouse Retina

Frontiers in Neural Circuits, 2018
The mammalian retina harbors over 100 different cell types. To understand how retinal circuits work, it is essential to systematically access each type. A widely used approach for achieving targeted transgene expression exploits promoter-driven Cre lines.
Andrew Jo, Jian Xu, Sercan Deniz, Suraj Cherian, Steven H. DeVries, Steven H. DeVries, Yongling Zhu, Yongling Zhu   +7 more
doaj   +1 more source

The Spatial Different Order Derivative Method of Gravity and Magnetic Anomalies for Source Distribution Inversion

Remote Sensing, 2021
Gravity and magnetic measurements are common remote sensing strategies to obtain the property change of observed targets. Nowadays, the characteristic value of the derivatives of gravity and magnetic anomalies is commonly used to detect the source ...
Yanbo Ming, Guoqing Ma, Lili Li, Jiangtao Han, Taihan Wang   +4 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Saturation flow versus green time at two‐stage signal controlled intersections [PDF]

Transport, 2009
Intersections are the key components of road networks considerably affecting capacity. As flow levels and experience have increased over the years, methods and means have been developed to cope with growing demand for traffic at road junctions.
Ahmed Boumediene, Kouider Brahimi, Noreddine Belguesmia, Khaled Bouakkaz   +3 more
doaj   +1 more source

Community-based multisensory environments as preventive public health interventions for mental well-being in older adults: evidence from a large-scale study in China

Frontiers in Public Health
The accelerating demographic transition has brought the mental health of older adults to the forefront of public health concerns. Middle-aged and older adults (aged 50–69 years), often described as the “young-old,” are particularly vulnerable to early ...
Han Zhang, Siqi Zhu
doaj   +1 more source

Data Delivery Delay Reduction for VANETs on Bi-Directional Roadway

IEEE Access, 2016
In this paper, we investigate the data delivery delay from source to destination for VANETs on bi-directional roadways. The topology includes bi-directional roadways, left-turn lane, straight through lane, right-turn lane with traffic lights deployed at ...
Chang Guo, Demin Li, Guanglin Zhang, Zhaoyuan Cui   +3 more
doaj   +1 more source

Road Safety Audit for the Intersection of US 59 and IA 9 in Osceola County, Iowa Final Report, March 2012 [PDF]

, 2012
The Iowa Department of Transportation (DOT) requested a road safety audit (RSA) of the US 59/IA 9 intersection in northwestern Iowa, just south of the Minnesota border, to assess intersection environmental issues and crash history and recommend ...

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