Results 1 to 10 of about 31,985 (192)

Inflammaging in the intervertebral disc [PDF]

Clinical and Translational Neuroscience, 2018
Degeneration of the intervertebral disc – triggered by ageing, mechanical stress, traumatic injury, infection, inflammation and other factors – has a significant role in the development of low back pain. Back pain not only has a high prevalence, but also a major socio-economic impact. With the ageing population, its occurrence and costs are expected to
Aleksandra Sadowska, Oliver Nic Hausmann, Karin Wuertz-Kozak   +2 more
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Mechanotransduction in intervertebral discs [PDF]

Journal of Cellular and Molecular Medicine, 2014
AbstractMechanotransduction plays a critical role in intracellular functioning—it allows cells to translate external physical forces into internal biochemical activities, thereby affecting processes ranging from proliferation and apoptosis to gene expression and protein synthesis in a complex web of interactions and reactions.
Po-Liang Lai, Chao-Min Cheng, Tsung-Ting Tsai, Chien-Fu Chen   +3 more
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Degeneration of the intervertebral disc.

Arthritis research & therapy, 2003
The intervertebral disc is a cartilaginous structure that resembles articular cartilage in its biochemistry, but morphologically it is clearly different. It shows degenerative and ageing changes earlier than does any other connective tissue in the body.
Urban, J, Roberts, S
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Nutrition of the Intervertebral Disc

Spine, 2004
A review of the literature on disc nutrition.To summarize the information on disc nutrition in relation to disc degeneration.The disc is avascular, and the disc cells depend on diffusion from blood vessels at the disc's margins to supply the nutrients essential for cellular activity and viability and to remove metabolic wastes such as lactic acid.
Urban, J, Smith, S, Fairbank, J
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Piezoelectricity in the Intervertebral disc

Journal of Biomechanics, 2020
Lower back pain is a major global health challenge that can often be caused by degeneration of the Intervertebral Disc (IVD). While IVD biomechanics are a key factor in the degenerative cycle, many mechanotransduction pathways remain unknown, in particular the electro-mechanical coupling in the loaded tissue. However, despite evidence for a role in the
Philip Poillot, Joseph O'Donnell, David T. O'Connor, Ehtsham Ul Haq, Christophe Silien, Syed A.M. Tofail, Jacques M. Huyghe   +6 more
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Prolapsed intervertebral disc [PDF]

BMJ, 2008
Prolapsed intervertebral disc is common—it is seen in up to a quarter of magnetic resonance scans and can be detected even in asymptomatic adults.1 Disc prolapse is genetically driven—twin studies indicate that at least 60% of the variance can be explained on genetic grounds and not by the commonly assumed environmental factors (work, trauma, exposure ...
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Classification of Intervertebral Disc Disease [PDF]

Frontiers in Veterinary Science, 2020
Intervertebral disc disease (IVDD) has been recognized in dogs since the 1800s, when the first descriptions of extruded disc material within the vertebral canal were published. In the intervening time our understanding of intervertebral disc pathology in dogs and cats has increased dramatically, with many variations of IVDD described. Whilst the volume
Joe Fenn, Natasha J. Olby, The Canine Spinal Cord Injury Consortium (CANSORT-SCI), Sarah A. Moore, Natasha J. Olby, Kady M. Gjessing, Rhanna M. Davidson, Jonathan M. Levine, Helen McWhorter, Melissa J. Lewis, Nick D. Jeffery, Maureen E. Mullins, Ronaldo Casimiro da Costa, Yvette S. Nout-Lomas, Joe Fenn, Nicolas Granger, Ingo Spitzbarth, Veronika M. Stein, Andrea Tipold, Ji-Hey Lim, Holger Volk   +20 more
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Methanolysis of the Intervertebral Disc

Clinical Chemistry, 1967
Abstract Methanolysis of intervertebral disc samples at 60° was largely hydrolysis as shown by the absence of methylated derivatives on chromatograms of the reaction products. Extent of the reaction increased with acid strength; the products were the same.
David Chan, Earl McNall, Marvin Fields, E. Wayne Hull   +3 more
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The pathophysiology of the intervertebral disc

Joint Bone Spine, 2001
After a review of disk structure, the pivotal role of disk cells in producing and renewing the extracellular disk matrix is emphasized. Disk cells rely on nutrients that diffuse through the vertebral endplates. Microelectrode methods have been developed to study nutrient diffusion and endplate permeability. Mechanical stimuli modify disk cell activity.
Bibby, SR, Jones, D, Lee, R, Yu, J, JPG, Urban   +4 more
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Intervertebral disc disease in Dachshunds radiographically screened for intervertebral disc calcifications [PDF]

Acta Veterinaria Scandinavica, 2014
Intervertebral disc disease (IDD) is a very common neurological disease, Dachshunds being the breed most often affected. In this breed, IDD has a hereditary background and is associated with intervertebral disc calcification (IDC), an indicator of severe intervertebral disc degeneration.
Outi Laitinen-Vapaavuori, Anu K. Lappalainen, Jouni Junnila, Elina Vaittinen   +3 more
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