Results 101 to 110 of about 31,985 (192)

Antisenescence therapies for age‐related bone loss: Target factors, medicines, biomedical materials

Clinical and Translational Medicine, Volume 15, Issue 6, June 2025.
With extended lifespans causing population aging, bone aging has become a worldwide issue. Cellular senescence in the bone microenvironment causes bone degeneration and dysfunction. This review summarises targets in cellular senescence and bone aging while detailing potential therapeutic strategies, including novel medicines and innovative biomedical ...
Qiyue Zhu, Menglong Hu, Likun Wu, Erfan Wei, Xingtong Pan, Hao Liu, Yunsong Liu   +6 more
wiley   +1 more source

A Novel Approach to Predict the Location and Fatigue Life of Intervertebral Disc Degeneration. [PDF]

Bioengineering (Basel)
Zhang Z, Wang T, Bian H, Shen X, Liang M, Teo EC, Jiang T.   +6 more
europepmc   +1 more source

Self-healing injectable multifunctional hydrogels for intervertebral disc disease. [PDF]

Mater Today Bio
Gu Z, He Y, Xiang H, Qin Q, Cao X, Jiang K, Zhang H, Li Y.   +7 more
europepmc   +1 more source

Analysis of Nicotine Toxicity and Mechanisms of Senescence in Nucleus Pulposus Cells Using Network Toxicology and Molecular Docking Technique

JOR SPINE, Volume 8, Issue 2, June 2025.
The current study improves cyber toxicology as a method of evaluating environmental toxicity and molecular biological qualities in addition to clarifying the possible molecular pathways of nicotine‐induced senescence in IVDD. ABSTRACT Aim Through the use of network toxicology, the research sought to determine whether cellular senescence and associated ...
Chen Jiang, Chao Song, Chaoqi Chen, Baoxin Shen, Lei Yang, Chi Zhang, Fei Liu, Xiaofei Wu, Feng Chen   +8 more
wiley   +1 more source

Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress. [PDF]

Front Pharmacol
Zhu Z, Huang Z, Zhang C, Xu B, Chen H, Pei S, Zhang B, Jie L, Shi X, Liu Y, Li Y, Shen X.   +11 more
europepmc   +1 more source

Phosphatidylethanolamine Protects Nucleus Pulposus Cells From Oxidative Stress‐Induced Cellular Senescence and Extracellular Matrix Degradation by Promoting Autophagy

JOR SPINE, Volume 8, Issue 2, June 2025.
In this study, we utilized LC/MS‐based untargeted metabolomics analysis to examine changes in the metabolite profiles of NP cells under stress conditions. Upon analysis, PE was identified as a differentially abundant metabolite for its decreased content within advanced‐stage NP cells.
Yijun Dong, Chuanfu Li, Shuangshuang Tu, Mingkai Liu, Kai Lv, Liqun Duan, Feng Zhang, Haiping Cai, Xi Chen, Wenzhi Zhang   +9 more
wiley   +1 more source

Exploring the molecular mechanisms underlying intervertebral disc degeneration by analysing multiple datasets. [PDF]

Sci Rep
Lin L, Li D, Cai G, Zheng G, Huang D, Liu H, Lin S, Zhao F.   +7 more
europepmc   +1 more source

Injection Volume Is a Better Predictor of Stiffness Restoration Than Injection Force in an In Vitro Study of Nucleus Augmentation of the Intervertebral Disc [PDF]

JOR Spine
This study investigated nucleus augmentation as an early intervention for intervertebral disc degeneration by injecting a biomaterial to restore disc height and functionality. Mechanical tests on bovine tail discs showed that treated discs exhibited similar stiffness to native discs, differing significantly from degenerated ones.
Warren J, Dixon A, Culbert M, Khan A, Mengoni M, Wilcox R.   +5 more
europepmc   +2 more sources

Physiological and Anthropometric Factors Associated With Spine Loading Estimates From Imaging‐Based Subject‐Specific Musculoskeletal Models

JOR SPINE, Volume 8, Issue 2, June 2025.
Utilizing CT scans from a population‐based cohort, we identified several physiological and anthropometric characteristics that were associated with loading estimates from imaging‐based musculoskeletal models. Shear loading is more complex than compressive loading and is not easily explained by basic clinical factors.
Brett T. Allaire, Fjola Johannesdottir, Mary L. Bouxsein, Dennis E. Anderson   +3 more
wiley   +1 more source

LGR6 modulates intervertebral disc degeneration through regulation of macrophage efferocytosis. [PDF]

J Transl Med
Li F, Shi Y, Chen J, Sun J, Shi J, Sun K, Zheng B.   +6 more
europepmc   +1 more source