Results 101 to 110 of about 92,764 (319)

A Phase 1 Study of the Pharmacokinetics, Safety, and Tolerability of Posdinemab (JNJ‐63733657) in Healthy Chinese Adults

The Journal of Clinical Pharmacology, EarlyView.
Abstract Posdinemab, a humanized immunoglobulin G1/κ monoclonal antibody, binds with high affinity to phosphorylated tau protein which is associated with Alzheimer's disease (AD) pathophysiology. Posdinemab reduced tau seeding in murine models and was well tolerated in Phase‐1 clinical studies.
Fangfang Wang, Juanfang Liu, Daisy Bai, Lingjue Li, Maggie Fedgchin, David Henley, Haiyan Li, Fan Zhang   +7 more
wiley   +1 more source

Overactivation of NF-kB pathway can induce apoptosis by down-regulating glycolysis in human degenerative nucleus pulposus cells

Heliyon
Intervertebral disc herniation, a prevalent condition in spinal surgery that frequently results in low back pain and lower limb dysfunction, significantly impacting patients' quality of life.
Pan Tang, Bo Liu
doaj   +1 more source

Co-culture of Adult Mesenchymal Stem Cells and Nucleus Pulposus Cells in Bilaminar Pellets for Intervertebral Disc Regeneration [PDF]

, 2009
Background: Our goal is to optimize stem cell-based tissue engineering strategies in the context of the intervertebral disc environment. We explored the benefits of co-culturing nucleus pulposus cells (NPC) and adult mesenchymal stem cells (MSC) using a ...
Allon, AA, Lotz, JC, Schneider, RA
core   +2 more sources

Degeneration of Lumbar Intervertebral Discs: Characterization of Anulus Fibrosus Tissue and Cells of Different Degeneration Grades [PDF]

, 2020
Stefan Stich, Michal Jagielski, Anja Fleischmann, Carola Meier, Patricia Bußmann, Benjamin Kohl, Julia Schmidt, Jan‐Philipp Krüger, Michaela Endres, Mario Čabraja, Kolja Reimann, Dominik Laue, Wolfgang Ertel, Michael Sittinger   +13 more
openalex   +1 more source

Regenerating and repairing degenerative intervertebral discs by regulating the micro/nano environment of degenerative bony endplates based on low-tension mechanics [PDF]

, 2022
Yan‐Jun Che, Jiangbo Guo, Yue Feng Hao, Zong‐Ping Luo   +3 more
openalex   +1 more source

Evaluation of Partial Volume Correction Techniques for Sodium MRI of the Achilles Tendon

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To evaluate partial volume correction (PVC) techniques for sodium MRI of the Achilles tendon in situ and in vivo. Methods Five PVC methods were evaluated including a volume ratio of the proton and sodium segmentations (PSSR), a modified least trimmed square (3D‐mLTS) linear regression, a geometric transfer matrix (GTM) approach, a ...
Rika Möller, Benedikt Kamp, Paula Leja, Thomas A. Thiel, Eric Bechler, Hans‐Jörg Wittsack, Gerald Antoch, Armin M. Nagel, Lena M. Wilms, Miriam Frenken, Anja Müller‐Lutz   +10 more
wiley   +1 more source

Evaluation of Intervertebral Disc Space Width Between 10th and 11th Thoracic Vertebrae in Cats Using Radiography and Magnetic Resonance Imaging

Veterinary Medicine and Science
Background It is well known that the T10–T11 intervertebral disc space is usually narrower than the adjacent intervertebral disc spaces in most dogs.
Jiwon Kim, Danbee Kwon, Bumseok Kim, Kichang Lee, Hakyoung Yoon   +4 more
doaj   +1 more source

Lipid Nanoparticles Delivering ClpP‐mRNA Suppress Pyroptosis and Senescence in Intervertebral Disc Degeneration via mTOR/BNIP3‐Activated Mitophagy

Rare Metals, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang, Zhiqiang Wang, Tong Zhang, Shicheng Qiu, Guang Yang, Yanzheng Gao, Xiaofeng Lian, Xin Peng   +7 more
wiley   +1 more source

Influence of facet joint tropism on the formation of intervertebral disc herniation in the lumbosacral spine

Хирургия позвоночника, 2018
Objective. To evaluate the influence of facet joint tropism on the formation of intervertebral disc hernias in the lumbosacral spine, and to determine the relationship between facet joint asymmetry and the type of hernia of the lumbar intervertebral ...
Vadim A. Byvaltsev, Ivan A. Stepanov, Alena K. Okoneshnikova   +2 more
doaj   +1 more source

Facet-sparing lumbar decompression with a minimally invasive flexible MicroBlade Shaver® versus traditional decompression: quantitative radiographic assessment. [PDF]

, 2012
BackgroundLaminectomy/laminotomy and foraminotomy are well established surgical techniques for treatment of symptomatic lumbar spinal stenosis. However, these procedures have significant limitations, including limited access to lateral and foraminal ...
Berven, Sigurd, Block, Jon E, Lauryssen, Carl, Miller, Larry E, Mimran, Ronnie, Sheinberg, Michael, Summa, Christopher   +6 more
core   +2 more sources