Results 121 to 130 of about 93,770 (350)

Development of a Grasshopper‐Leg‐Inspired Back‐Type Exoskeleton for the Reduction of Muscle Activation During Stoop Activities

open access: yesJournal of Field Robotics, EarlyView.
ABSTRACT Farmers frequently suffer from musculoskeletal disorders, particularly lower back pain (LBP), mainly due to occupational ergonomic factors such as repetitive stooping and lifting. This study proposes using an exoskeleton to reduce LBP risk by providing external torque to the hip joints.
Dang Khanh Linh Le, Wei Chih Lin
wiley   +1 more source

Complex Mechanical Loading and Pro‐Inflammatory Cytokines in Intervertebral Disc Degeneration [PDF]

open access: yesJOR Spine
This study investigated the combined effects of dynamic compression and torsion with major pro‐catabolic cytokine interleukin‐1 beta (IL‐1β) and its inhibitor: interleukin‐1 receptor antagonist (IL‐1Ra), on bovine IVD in an ex vivo organ culture system and further evaluated the mechanical effects using a subject‐personalized finite element model based ...
Crump K   +8 more
europepmc   +2 more sources

Emerging Triboelectric Nanogenerators for In‐Body Implantation

open access: yesSmall Methods, EarlyView.
This review explores functional implantable triboelectric nanogenerators in biomedical applications, discussing their mechanisms, electricity generation, and design approaches. To solve postimplantation challenges, four types of triboelectric nanogenerators (TENGs) are introduced: stretchable, bioadhesive, on‐demand biodegradable, and multiresponsive ...
Xiao Xiao   +4 more
wiley   +1 more source

Mechanosensitive Cell‐Laden Shape‐Memory Scaffolds Engineered via Cryogelation

open access: yesSmall Structures, EarlyView.
GelMA‐based shape‐memory scaffolds encapsulating human adipose‐derived stem cells are fabricated via cryogelation, showing rapid recovery and high cell viability. Under cyclic compression, they promoted mechanotransduction gene expression, and composite formulations (collagen/GelMA, dECM/GelMA) retained robust shape‐memory, highlighting their promise ...
JaeYoon Lee   +4 more
wiley   +1 more source

Treatment of discospondylitis in dogs: A systematic review

open access: yesVeterinary Record, EarlyView.
Abstract Background Both medical and surgical techniques have been reported to manage canine discospondylitis, although data on clinical effectiveness and long‐term prognosis remain limited. Methods A systematic review of studies on treatment approaches, follow‐up data and investigation methods was conducted.
Vasileios Ioannis Vallios   +4 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus   +5 more
wiley   +1 more source

Axial T2* mapping in intervertebral discs: a new technique for assessment of intervertebral disc degeneration [PDF]

open access: yes, 2018
Objectives: To demonstrate the potential benefits of biochemical axial T2* mapping of intervertebral discs (IVDs) regarding the detection and grading of early stages of degenerative disc disease using 1.5-Tesla magnetic resonance imaging (MRI) in a ...
Benneker, Lorin   +5 more
core  

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang   +18 more
wiley   +1 more source

Investigation of deformation behavior of cervical spine segment during the deformation of the intervertebral disc [PDF]

open access: yes, 2018
In this paper the stress-strain state of the model cervical spine segment is regarded. The deformation behavior of the intervertebral disc during the deformation of the intervertebral disc is ...
Рикун, Ю. А.
core  

AAV6 as an effective gene delivery vector for prolonged transgene expression in intervertebral disc cells in vivo

open access: diamond, 2020
Chi Heon Kim   +4 more
openalex   +1 more source

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