Results 151 to 160 of about 93,770 (350)

Innovating intervertebral disc degeneration therapy: Harnessing the power of extracellular vesicles

Journal of Orthopaedic Translation
Intervertebral disc degeneration is the leading cause of low back pain, imposing significant burdens on patients, societies, and economies. Advancements in regenerative medicine have spotlighted extracellular vesicles as promising nanoparticles for ...
Shanfeng Chen, Yiming Dou, Yiming Zhang, Xun Sun, Xinyu Liu, Qiang Yang   +5 more
doaj   +1 more source

Acute hydrated non-compressive nucleus pulposus extrusion: what do we know so far? [PDF]

, 2017
BELTRAN, CHANG, DE RISIO, FENN, FENN, GRIFFITHS, HANSEN, LU, MARI, MCKEE, ROS, TAYLOR-BROWN   +11 more
core   +2 more sources

A novel multi-omics approach for identifying key genes in intervertebral disc degeneration [PDF]

Xuan Zhao, Qijun Wang, Shuaikang Wang, Wei Wang, Xiaolong Chen, Shibao Lu   +5 more
openalex   +1 more source

Leptin Regulates Intervertebral Disc Calcification and Ossification by Promoting Glycolysis Through OCN/HIF-1α Axis. [PDF]

J Cell Mol Med
ABSTRACT During intervertebral disc degeneration (IDD), cartilage endplate (CEP) cells undergo calcification and ossification, relying primarily on glycolysis for energy metabolism. Leptin (LEP) initiates the IDD, while its underlying mechanism related to glycolysis remains elusive in CEP cells. To investigate the underlying mechanism of LEP on IDD, an
Li H, Yu C, Li Z, Yao S, Mo K, Peng G, Huang Y, Wei J.   +7 more
europepmc   +2 more sources

Circular RNAs in nucleus pulposus cell function and intervertebral disc degeneration [PDF]

, 2019
Zheng Li, Xin Chen, Yuming Zhong, Shugang Li, Matthew T.V. Chan, William Ka Kei Wu   +5 more
openalex   +1 more source

Comparative Analysis of Three Vertebral Screw Placement Directions in Anterior Thoracolumbar Fracture Surgery: A Finite Element Study

Orthopaedic Surgery, Volume 17, Issue 5, Page 1464-1477, May 2025.
This study compares the biomechanical effects of three anterior fixation systems in thoracolumbar surgery—HXTL, NHXTL, and Medtronic's CD Horizon ANTERIOR. Finite element analysis evaluates stress and displacement across vertebral bodies and support structures under varying load conditions. Results indicate the HXTL system minimizes nail–rod stress yet
Xuehai Jia, Yanjun Xie, Yi Yang, Yi Deng, Kerui Zhang, Changyong Shen, Ya Li, Litai Ma   +7 more
wiley   +1 more source

Aging aggravates intervertebral disc degeneration by regulating transcription factors toward chondrogenesis [PDF]

, 2019
Matthew J. Silva, Nilsson Holguin
openalex   +1 more source

Factors and Experiences Associated With Unscheduled Hospital Readmission After Lateral Lumbar Interbody Fusion: A Case–Controlled Study

Orthopaedic Surgery, Volume 17, Issue 5, Page 1389-1396, May 2025.
The research utilized a case–control approach to contrast patients experiencing unscheduled readmissions with those undergoing planned readmissions due to staged surgery. Findings indicated a 3.88% rate of unscheduled readmissions, mainly linked to adjacent segment disease, with 3.35% necessitating reoperation.
Wangmi Liu, Feng Zhang, Yiqing Tao, Hao Li, Qixin Chen, Fangcai Li   +5 more
wiley   +1 more source

Induced muscle relaxation in the treatment of lumbar intervertebral disc lesions

, 1966
R. H. V. Hafner, C D T James, R Robertshaw   +2 more
openalex   +2 more sources

Establishing a Staging System for Adjacent Segment Disease and Exploring Its Significance in Guiding Surgical Decisions: A Retrospective Study

Orthopaedic Surgery, Volume 17, Issue 5, Page 1418-1432, May 2025.
Developed a staging system for adjacent segment disease based on degeneration characteristics. Verified the feasibility and reliability of stage‐guided surgical decision‐making through surgical data, radiological data, and follow‐up data. This staging system was closely correlated with intervertebral disc degeneration and disc height while also ...
Changpeng Qu, Jianwei Guo, Hao Tao, Chuanli Zhou, Kai Zhu, Yihao Sun, Lei Li, Zhiming Liu, Hao Zhang, Xuexiao Ma   +9 more
wiley   +1 more source