Results 161 to 170 of about 43,436 (258)

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, Volume 7, Issue 4, August 2026.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Gingerol-loaded hollow manganese dioxide nanoparticles attenuate intervertebral disc oxidative stress. [PDF]

RSC Adv
Liu X, Lu B, Zhou Y, Zhang C, Shi F, Feng G, Luo X, Xiao D.   +7 more
europepmc   +1 more source

Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema

Allergy, Volume 81, Issue 8, Page 2815-2832, August 2026.
This study performed an unbiased molecular profiling of CHE patients across diverse etiologies to identify shared pathogenic drivers and evaluate the impact of IL‐4Rα blockade via dupilumab over 16 weeks. CHE shows a mixed immune signature involving type 1, 2, and 3 pathways with features of atopic dermatitis and psoriasis.
Perrine Gery, Rüçhan Ekren, Emilie Bérard, Aurélie Du‐Thanh, Hugo Rimet, Fatma Jendoubi, Vanina Lenief, Nadia Raison‐Peyron, Amel Bouznad, Maria P. Konstantinou, Jonathan Rioual, Lilian Basso, Juliette Mouiren, Manon Boussier, Brigitte Milpied, Cristina Bulai Livideanu, Louise Jaulent, Florence Hacard, Marine A. Lefevre, Audrey Nosbaum, Julien Seneschal, Marc Vocanson, Carle Paul, Nicolas Gaudenzio, Marie Tauber, on behalf of the French Atopic Dermatitis Network from de GREAT Research group   +25 more
wiley   +1 more source

Molecular insights into Atorvastatin's role in delaying intervertebral disc degeneration. [PDF]

Front Cell Dev Biol
Li Y, Wang L, Wang X, Li K, Wang Q, Gao K, Zhang C, Lv C.   +7 more
europepmc   +1 more source

Pharmacological Inhibition of Cav2.2 Channels by Recombinant Phα1β Toxin (CTK01512‐2)

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.
The recombinant Phα1β toxin (CTK01512‐2) partially and reversibly inhibits Cav2.2 calcium channels in HEK‐293 cells. CTK01512‐2 displays dose‐dependent inhibition of N‐type calcium currents, with an IC50 of 3.94 nM. In vivo, CTK01512‐2 effectively reduces mechanical allodynia in a neuropathic pain model, confirming its antinociceptive activity ...
Natália Virtude Carobin, Thamyris Reis Moraes, Luana Assis Ferreira, Christopher Kushmerick, Marcus Vinícius Gomez, Célio José Castro Junior   +5 more
wiley   +1 more source

CEST MRI: Translational prospects for intervertebral disc degeneration - from basic research to clinical applications. [PDF]

J Orthop Translat
Chen R, Wang H, Li Y, Zhang G, Zhang X, Qu X, Bai W, Li Z, Wu Y, Liang S, Wangchen M, Li N, Kong P, Wei X.   +13 more
europepmc   +1 more source

The Role of Epicardial and Visceral Fat in Severe Respiratory Infections: Associations With Adverse Outcomes

Clinical Obesity, Volume 16, Issue 4, August 2026.
ABSTRACT Excess adipose tissue has been extensively studied due to its role in the development of chronic diseases and inflammatory conditions. Obesity and visceral adipose tissue (VAT, fat stored within the abdominal cavity and around organs) are associated with increased susceptibility to respiratory infections and chronic low‐grade systemic ...
Rebecca Baumgartner, Jéssica A. de Paula, Cleverson A. Leitão, Gabriela Lazzaron‐Slob, Estela I. Rabito, Emilton L. Junior   +5 more
wiley   +1 more source

Causal relationship between intervertebral disc degeneration and neurological disorders: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Cao X.
europepmc   +1 more source

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation, Volume 59, Issue 8, August 2026.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
wiley   +1 more source

Newly identified intervertebral fat pad degenerates after intervertebral disc injury in a rat model of degeneration

Journal of Anatomy, Volume 249, Issue 2, Page 435-444, August 2026.
This study characterizes a newly‐described intervertebral fat pad (IVFP) anterior to rat IVDs, with evidence for its existence in mice and human IVDs as well. In rats, the IVFP gradually degenerated following IVD injury with changes in adipocyte size and fibrous tissue infiltration, suggesting it could play a functional role in IVD health and ...
Niklas H. Koehne, Irina Heggli, Agnieszka A. Karol, Alon Lai, Svenja Illien‐Jünger, Andrew C. Hecht, Nilsson Holguin, James C. Iatridis   +7 more
wiley   +1 more source