Results 21 to 30 of about 90,995 (334)

Inhibition of lysyl oxidase accelerates intervertebral disc degeneration induced by apoptosis of nucleus pulposus cells

open access: yes陆军军医大学学报, 2023
Objective To explore the role and possible mechanism of lysyl oxidase (LOX) in age-related degeneration of intervertebral disc. Methods Six SD rats, aged of 2, 8 and 20 months respectively, were subjected, and then underwent intervertebral disc MRI and X-
LI Jianmin   +3 more
doaj   +1 more source

Sal003 alleviated intervertebral disc degeneration by inhibiting apoptosis and extracellular matrix degradation through suppressing endoplasmic reticulum stress pathway in rats

open access: yesFrontiers in Pharmacology, 2023
Apoptosis and extracellular matrix degradation of the nucleus pulposus are the main initiators of intervertebral disc degeneration (IVDD) and can be explained by endoplasmic reticulum (ER) stress.
Yan Chen   +10 more
doaj   +1 more source

Clinical and magnetic resonance imaging characteristics of thoracolumbar intervertenral disk extrusions and protrusions in large breed dogs [PDF]

open access: yes, 2002
It has recently been shown that the fat-derived hormone adiponectin has the ability to decrease hyperglycemia and to reverse insulin resistance. However, bacterially produced full-length adiponectin is functionally inactive. Here, we show that endogenous
Beltran, E   +5 more
core   +4 more sources

HISTOLOGICAL AND STRUCTURAL STUDY OF PROLAPSED INTERVERTEBRAL DISC [PDF]

open access: yesBasrah Journal of Surgery, 2006
The research of the etiology of low back pain and right leg pain has been focused on the study of histological degenerative changes of human intervertebral disc prolapse.
Khalida K Jbara, Thamer A Hamdan
doaj   +1 more source

Equine cervical intervertebral disc degeneration is associated with location and MRI features [PDF]

open access: yes, 2019
Morphology of the equine cervical intervertebral disc is different from that in humans and small companion animals and published imaging data are scarcely available.
Back, Willem   +6 more
core   +1 more source

Protective role of the alpha-1-antitrypsin in intervertebral disc degeneration

open access: yesJournal of Orthopaedic Surgery and Research, 2021
Background Intervertebral disc degeneration is a complex disease with high prevalence. It suggests that cell death, senescence, and extracellular matrix degradation are involved in the pathogenesis. Alpha-1 antitrypsin (AAT), a serine protease inhibitor,
Weikun Liu, Yanfu Wang
doaj   +1 more source

Degeneration of the intervertebral disc.

open access: yesArthritis research & therapy, 2003
The intervertebral disc is a cartilaginous structure that resembles articular cartilage in its biochemistry, but morphologically it is clearly different. It shows degenerative and ageing changes earlier than does any other connective tissue in the body.
Urban, J, Roberts, S
openaire   +4 more sources

Pressure distributions inside intervertebral discs under unilateral pedicle screw fixation in a porcine spine model

open access: yesJournal of Orthopaedic Surgery and Research, 2018
Background Little data are available regarding the effects of pedicle screws on the intervertebral disc stress for different spinal segments. The aim of this study was to analyze the intervertebral disc stress in response to the placement of pedicle ...
Zhao Meng   +5 more
doaj   +1 more source

Physical disruption of intervertebral disc promotes cell clustering and a degenerative phenotype [PDF]

open access: yes, 2019
© 2019, The Author(s). To test the hypothesis that physical disruption of an intervertebral disc disturbs cell-matrix binding, leading to cell clustering and increased expression of matrix degrading enzymes that contribute towards degenerative disc cell ...
Adams, M.A.   +6 more
core   +1 more source

Nutrition of the Intervertebral Disc

open access: yesSpine, 2004
A review of the literature on disc nutrition.To summarize the information on disc nutrition in relation to disc degeneration.The disc is avascular, and the disc cells depend on diffusion from blood vessels at the disc's margins to supply the nutrients essential for cellular activity and viability and to remove metabolic wastes such as lactic acid.
Urban, J, Smith, S, Fairbank, J
openaire   +4 more sources

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