Results 21 to 30 of about 52,505 (294)

Exosomes and exosomal miRNAs: A new therapy for intervertebral disc degeneration

Frontiers in Pharmacology, 2022
Low back pain has been found as a major cause of global disease burden and disability. Intervertebral disc degeneration is recognized as the vital factor causing low back pain.
Zhichao Li, Yan Wu, Guoqing Tan, Zhanwang Xu, Haipeng Xue, Haipeng Xue   +5 more
doaj   +1 more source

Application of single and cooperative different delivery systems for the treatment of intervertebral disc degeneration

Frontiers in Bioengineering and Biotechnology, 2022
Intervertebral disc (IVD) degeneration (IDD) is the most universal pathogenesis of low back pain (LBP), a prevalent and costly medical problem across the world.
Zongtai Liu, Changfeng Fu
doaj   +1 more source

Effects of Changes in Osmolarity on the Biological Activity of Human Normal Nucleus Pulposus Mesenchymal Stem Cells

Stem Cells International, 2022
The expansion and maintenance of the NPMSC (nucleus pulposus mesenchymal stem cell) phenotype are considered as potential therapeutic tools for clinical applications in intervertebral disc tissue engineering and regenerative medicine.
Hua Zhang, Wei Li, YaoHong Wu, Shengquan Zhang, Jie Li, Letian Han, Haoyu Chen, Ziyu Wang, Cailiang Shen, Yinshun Zhang, Hui Tao   +10 more
doaj   +1 more source

The pathophysiology of the intervertebral disc

Joint Bone Spine, 2001
After a review of disk structure, the pivotal role of disk cells in producing and renewing the extracellular disk matrix is emphasized. Disk cells rely on nutrients that diffuse through the vertebral endplates. Microelectrode methods have been developed to study nutrient diffusion and endplate permeability. Mechanical stimuli modify disk cell activity.
Bibby, SR, Jones, D, Lee, R, Yu, J, JPG, Urban   +4 more
openaire   +4 more sources

Development of a deep learning model for automatic detection of narrowed intervertebral disc space sites in caudal thoracic and lumbar lateral X-ray images of dogs

Frontiers in Veterinary Science
Intervertebral disc disease is the most common spinal cord-related disease in dogs, caused by disc material protrusion or extrusion that compresses the spinal cord, leading to clinical symptoms.
Junseol Park, Junseol Park, Hyunwoo Cho, Yewon Ji, Kichang Lee, Hakyoung Yoon, Hakyoung Yoon   +6 more
doaj   +1 more source

Association of magnetic resonance assessed disc degeneration and late clinical recurrence in dogs treated surgically for thoracolumbar intervertebral disc extrusions

Journal of Veterinary Internal Medicine, 2021
Background Radiographic signs of intervertebral disc mineralization are thought to indicate sites of future recurrence of disc extrusion (Hansen type I) but the relationship between evidence of disc degeneration on magnetic resonance imaging (MRI) and ...
Sara Longo, Sergio A. Gomes, Chiara Briola, Katherine Duffy, Mike Targett, Nick D. Jeffery, Paul Freeman   +6 more
doaj   +1 more source

Intervertebral disc disease in Dachshunds radiographically screened for intervertebral disc calcifications [PDF]

Acta Veterinaria Scandinavica, 2014
Intervertebral disc disease (IDD) is a very common neurological disease, Dachshunds being the breed most often affected. In this breed, IDD has a hereditary background and is associated with intervertebral disc calcification (IDC), an indicator of severe intervertebral disc degeneration.
Outi Laitinen-Vapaavuori, Anu K. Lappalainen, Jouni Junnila, Elina Vaittinen   +3 more
openaire   +3 more sources

The Immune Privilege of the Intervertebral Disc: Implications for Intervertebral Disc Degeneration Treatment [PDF]

International Journal of Medical Sciences, 2020
The intervertebral disc (IVD) is the largest avascular organ of the body. It is composed of three parts: the nucleus pulposus (NP), the annulus fibrosus (AF) and the cartilaginous endplate (CEP). The central NP is surrounded by the AF and sandwiched by the two CEPs ever since its formation.
Bing Liu, Zhen Sun, Zhuojing Luo
openaire   +3 more sources

The Influence of Intervertebral Disc Microenvironment on the Biological Behavior of Engrafted Mesenchymal Stem Cells

Stem Cells International, 2022
Intervertebral disc degeneration is the main cause of low back pain. Traditional treatment methods cannot repair degenerated intervertebral disc tissue.
Jing Zhang, Wentao Zhang, Tianze Sun, Jinzuo Wang, Ying Li, Jing Liu, Zhonghai Li   +6 more
doaj   +1 more source

The Comparison between Herniated and Non-Herniated Disc Levels Regarding Intervertebral Disc Space Height and Disc Degeneration, A Magnetic Resonance Study

Diagnostics, 2023
Purpose: The main purpose of this study was to evaluate the intervertebral disc height and intervertebral disc degeneration between the normal group and the group with disc herniation at the level of the L4–L5 intervertebral disc by MRI using the ...
Türkhun Çetin, Sevket Kahraman, Volkan Kızılgöz, Sonay Aydın   +3 more
doaj   +1 more source