Results 91 to 100 of about 84,616 (318)

Exosomal MATN3 of Urine‐Derived Stem Cells Ameliorates Intervertebral Disc Degeneration by Antisenescence Effects and Promotes NPC Proliferation and ECM Synthesis by Activating TGF‐β [PDF]

, 2021
Zhu Guo, Weiliang Su, RongYao Zhou, Guo-qing Zhang, Shuai Yang, Xiaolin Wu, Chensheng Qiu, Wenbin Cong, Nana Shen, Jianwei Guo, Chang Liu, Shang‐You Yang, Dongming Xing, Yan Wang, Bohua Chen, Hongfei Xiang   +15 more
openalex   +1 more source

Lipid Nanoparticles Delivering ClpP‐mRNA Suppress Pyroptosis and Senescence in Intervertebral Disc Degeneration via mTOR/BNIP3‐Activated Mitophagy

Rare Metals, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang, Zhiqiang Wang, Tong Zhang, Shicheng Qiu, Guang Yang, Yanzheng Gao, Xiaofeng Lian, Xin Peng   +7 more
wiley   +1 more source

Experimental model of intervertebral disc degeneration by needle puncture in Wistar rats

Brazilian Journal of Medical and Biological Research, 2013
Animal models of intervertebral disc degeneration play an important role in clarifying the physiopathological mechanisms and testing novel therapeutic strategies.
A.C. Issy, V. Castania, M. Castania, C.E.G. Salmon, M.H. Nogueira-Barbosa, E. Del Bel, H.L.A. Defino   +6 more
doaj   +3 more sources

Mechanisms and therapeutic strategies for senescence-associated secretory phenotype in the intervertebral disc degeneration microenvironment

Journal of Orthopaedic Translation
As a permanent state of cell cycle arrest, cellular senescence has become an important factor in aging and age-related diseases. As a central regulator of physiology and pathology associated with cellular senescence, the senescence associated secretory ...
Yang Liu, Yiming Dou, Xun Sun, Qiang Yang   +3 more
doaj   +1 more source

TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo

Arthritis Research & Therapy, 2023
Background Intervertebral disc degeneration (IDD) is one of the most common disorders related to the spine. Inflammation, apoptosis and extracellular matrix (ECM) degradation contribute to disc degeneration in nucleus pulposus cells (NPCs).
Kun Wang, Dengbo Yao, Yuxi Li, Ming Li, Weike Zeng, Zhuangyao Liao, Engming Chen, Shixin Lu, Kaihui Su, Zhen Che, Yuwei Liang, Peng Wang, Lin Huang   +12 more
doaj   +1 more source

Association of COL2A1rs2276454, rs1793953, COL9A1rs1135056, COL11A1rs1676486 structure-forming collagens of the nucleus pulposus with degeneration of intervertebral discs L5-L4, L5-S1

Patologìâ, 2023
Aim. The purpose of the work was to determine the relationship between degenerative changes of the L5-S1 and L4-L5 intervertebral discs with collagen mononucleotide variants COL2A1rs2276454, rs1793953, COL9A1rs1135056, COL11A1rs1676486 among ethnic ...
Ye. H. Pedachenko, I. H. Vasylieva, M. V. Khyzhniak, O. S. Halanta, N. H. Chopyk, O. I. Tsiubko, A. B. Hriazov, O. S. Nekhlopochyn, T. A. Ksenzov, A. B. Dmytrenko, T. A. Makarova   +10 more
doaj   +1 more source

Functional outcome following direct repair or intervertebral fusion for adolescent spondylolysis : a systematic review [PDF]

, 2012
A systematic review of the literature was performed to establish whether direct repair of the pars defect or intervertebral fusion achieves better Oswestry Disability Index scores in adolescent spondylolysis or low-grade spondylolisthesis.
Cooke, Stephen J., Westacott, Daniel J.
core   +1 more source

Quercetin Alleviates Intervertebral Disc Degeneration by Modulating p38 MAPK‐Mediated Autophagy [PDF]

, 2021
Shuwen Zhang, Weidong Liang, Yakefu Abulizi, Tao Xu, Rui Cao, Chuanhui Xun, Jian Zhang, Weibin Sheng   +7 more
openalex   +1 more source

Mitochondrial quality control in intervertebral disc degeneration

Experimental and Molecular Medicine, 2021
Intervertebral disc degeneration (IDD) is a common and early-onset pathogenesis in the human lifespan that can increase the risk of low back pain. More clarification of the molecular mechanisms associated with the onset and progression of IDD is likely ...
Yu Song, Saideng Lu, Wen Geng, Xiaobo Feng, Rongjin Luo, Gaocai Li, Cao Yang   +6 more
semanticscholar   +1 more source

New Advances of Degradable Magnesium‐Based Metal Biomaterials in the Field of Orthopedics

Rare Metals, EarlyView.
ABSTRACT Based on their outstanding biomechanical properties and superior osteogenic activity, magnesium (Mg) and its alloys have been extensively investigated for their biocompatibility and therapeutic efficacy in treating fractures and bone defects.
Jia‐Nan Yu, Shao‐Sheng Jia, Rong‐Bang Sun, Tong Zhang, Ling‐Chuang Bai, Di Mei, Shi‐Jie Zhu, Lan Chen, Shao‐Kang Guan   +8 more
wiley   +1 more source