Results 91 to 100 of about 25,892 (278)

Exosomes from M2c macrophages alleviate intervertebral disc degeneration by promoting synthesis of the extracellular matrix via MiR‐124/CILP/TGF‐β

, 2023
Yi Liu, Mintao Xue, Yaguang Han, Yucai Li, Bing Xiao, Weiheng Wang, Jiangming Yu, Xiaojian Ye   +7 more
openalex   +1 more source

Arthroscopic‐Assisted Uni‐Portal Spinal Surgery Combined With Kirschner Wire Anchoring for Cervical Spondylotic Radiculopathy: A Technical Note and Preliminary Clinical Results

Orthopaedic Surgery, EarlyView.
This study is the first to describe the use of arthroscopic‐assisted uniportal spinal surgery (AUSS) with Kirschner‐wire anchoring in a cohort of 15 patients with cervical spondylotic radiculopathy (CSR). Postoperatively, patients experienced significant pain relief and marked improvement in cervical function.
Shan Wu, Jiaxuan Zhang, Renjie Dong, Yihang He, Feng Huang, Zhenyuan Lu, Yang Liu, Guosheng Zhao, Zhenyong Ke, Yang Wang   +9 more
wiley   +1 more source

Degeneration and regeneration of the intervertebral disc: lessons from development

Disease Models & Mechanisms, 2011
Degeneration of the intervertebral discs, a process characterized by a cascade of cellular, biochemical, structural and functional changes, is strongly implicated as a cause of low back pain.
Lachlan J. Smith, Nandan L. Nerurkar, Kyung-Suk Choi, Brian D. Harfe, Dawn M. Elliott   +4 more
doaj   +1 more source

What Is Your Diagnosis? Leukocytosis With Abnormal WDF and WNR Scattergrams From the Sysmex XN‐1000V in a Dog

Veterinary Clinical Pathology, EarlyView.
SUMMARY In dogs, the WDF and WNR scattergrams from the Sysmex XN‐1000V enable a highly presumptive interpretation of mastocytemia. This is the first description of abnormal circulating mast cells using the Sysmex XN‐1000V, which appears to function similarly to the previous analyzer, the Sysmex XT‐2000iV.
Javier Martínez‐Caro, Marta Lemos, Josep Pastor   +2 more
wiley   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Degenerative relationships in lumbar intervertebral discs and facet joints: an MRI-based comparative study of asymptomatic individuals and patients with chronic and intermittent low back pain

Frontiers in Bioengineering and Biotechnology
Degeneration of intervertebral discs and facet joints are common conditions that are thought to be interrelated. This study aimed to investigate the morphological interplay between disc and facet degeneration, as well as relationships between adjacent ...
Hendrik Schmidt, Sandra Reitmaier, Daishui Yang, Georg Duda, Matthias Pumberger   +4 more
doaj   +1 more source

Sex Hormones Attenuate Pro‐Inflammatory Gene Expression in Nucleus Pulposus and Annulus Fibrosus Cells in a Cell‐Type Specific Manner

JOR SPINE, Volume 9, Issue 1, March 2026.
Methodological overview of primary bovine NP and AF cell culture. Pro‐ and anti‐inflammatory gene and protein expression analyses were performed after 24 h of pro‐inflammatory stimulus, followed by 3 days of cotreating cells with sex hormones in addition to pro‐inflammatory cytokines.
Jeffrey L. Hutchinson, Andrew E. Leung, Cheryle A. Séguin   +2 more
wiley   +1 more source

Complex Mechanical Loading and Pro‐Inflammatory Cytokines in Intervertebral Disc Degeneration

JOR SPINE, Volume 9, Issue 1, March 2026.
This study investigated the combined effects of dynamic compression and torsion with major pro‐catabolic cytokine interleukin‐1 beta (IL‐1β) and its inhibitor: interleukin‐1 receptor antagonist (IL‐1Ra), on bovine IVD in an ex vivo organ culture system and further evaluated the mechanical effects using a subject‐personalized finite element model based ...
Katherine B. Crump, Estefano Muñoz‐Moya, Kim de Graaf, Paola Bermudez‐Lekerika, Nicole Schwendener, Wolf‐Dieter Zech, Christine L. Le Maitre, Jérôme Noailly, Benjamin Gantenbein   +8 more
wiley   +1 more source

Influence of the Intervertebral Disc Microenvironment on Matrix Synthesis and Metabolism in Goat Nucleus Pulposus Cells

JOR SPINE, Volume 9, Issue 1, March 2026.
Goat nucleus pulposus cells cultured under clinically relevant oxygen, glucose, pH, and osmolarity revealed pH to have the most influential impact on viability and glycosaminoglycan synthesis. Interactions between factors showed that disc cell behavior is shaped by the microenvironment, highlighting its importance in regenerative therapy design for the
Niamh Wilson, Tara Ní Néill, Jake McDonnell, Emily McDonnell, Pieter A. J. Brama, Conor T. Buckley   +5 more
wiley   +1 more source

Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration

Nature Communications
Intervertebral disc degeneration is a natural process during aging and a leading cause of lower back pain. Here, we generate a comprehensive atlas of nucleus pulposus cells using single-cell RNA-seq analysis of human nucleus pulposus tissues (three males
Fan Chen, Linchuan Lei, Shunlun Chen, Zhuoyang Zhao, Yuming Huang, Guowei Jiang, Xingyu Guo, Zemin Li, Zhaomin Zheng, Jianru Wang   +9 more
doaj   +1 more source