Results 91 to 100 of about 38,647 (321)

Modelo de degeneración del disco intervertebral por punción de la cola de ratas Wistar: evaluación histológica y radiográfica [PDF]

, 2010
OBJETIVO: descrever a caracterização histológica e radiográfica do método de indução da degeneração do disco intervertebral da cauda de ratos Wistar induzida por meio de punção.
CASTANIA, Vitor, DEFINO, Helton L. A., DEL BEL, Elaine, IYOMASA, Mamie Mizusaki, JONG, Joost J. A. de, PEREIRA, Ana Carolina de C. Issy, PITOL, Dimitrius Leonardo   +6 more
core   +2 more sources

Modulating Macrophage–Nucleus Pulposus Cell Crosstalk via Sequential Drug Delivery Attenuates Disc Degeneration

Advanced Science, EarlyView.
The G‐CS/MSN drug delivery system enhances intervertebral disc repair through sequential drug release. Abstract Intervertebral disc degeneration (IDD) is characterized by an inflammatory environment and dysregulation of the extracellular matrix metabolism (ECM).
Xiangzhen Kong, Rui Hu, Peng Zhang, Qi Li, Kangle Song, Hanwen Gu, Jihui Zheng, Shen Liu, Liang Liu, Lin Jin, Lei Cheng, Chengwei Li, Zhijian Wei   +12 more
wiley   +1 more source

Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs. [PDF]

, 2016
The main pathogenesis of intervertebral disc (IVD) herniation involves disruption of the annulus fibrosus (AF) caused by ageing or excessive mechanical stress and the resulting prolapse of the nucleus pulposus.
Asahara, Hiroshi, Ichinose, Shizuko, Inagawa, Masayo, Inui, Masafumi, Ito, Yoshiaki, Kataoka, Kensuke, Kayama, Tomohiro, Lotz, Martin K, Masuda, Koichi, Mori, Masaki, Nakamichi, Ryo, Onizuka, Naoko, Ozaki, Toshifumi, Sakai, Daisuke, Suzuki, Hidetsugu   +14 more
core   +1 more source

Open Challenges and Opportunities in Piezoelectricity for Tissue Regeneration

Advanced Science, EarlyView.
This review provides an intriguing review of the recent advancements, challenges, and future perspectives regarding the application of piezoelectric scaffolds in tissue regeneration. The detailed exposition is anticipated to propel the advancement of personalized and intelligent piezoelectric implants, thereby fostering significant progress in this ...
Xiaoling Deng, Yu Zhuang, Jinjie Cui, Liyun Wang, Huilu Zhan, Xudong Wang, Kaili Lin, Changyong Yuan   +7 more
wiley   +1 more source

Aquaporin expression in the human and canine intervertebral disc during maturation and degeneration [PDF]

, 2019
The intervertebral disc (IVD) is a highly hydrated tissue, the rich proteoglycan matrix imbibes water, enabling the disc to withstand compressive loads. During ageing and degeneration increased matrix degradation leads to dehydration and loss of function.
Snuggs, Joseph, Day, Rebecca, Bach, Frances, Conner, Matthew, Bunning, Rowena, Tryfonidou, Marianna, Le Maitre, Christine   +6 more
core   +1 more source

Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives

Aggregate, EarlyView.
Triterpenoids serve as both exceptional molecular motifs for supramolecular assembly and versatile therapeutic agents, offering broad biological functions to improve health outcomes and enhance treatment efficacy. This review comprehensively summarizes recent advances in triterpenoid‐based supramolecular systems, including their roles as functional ...
Jie Zhong, Juan C. Mareque‐Rivas, Xinmiao Lan, Yu‐Xiong Su   +3 more
wiley   +1 more source

BIOCHEMICAL AND BIOMECHANICAL SUBSTANTIATION OF REPARATIVE REGENERATION OF INTERVERTEBRAL DISCS IN PATIENTS WITH DEGENERATIVE DISC DISEASES

Східноукраїнський медичний журнал, 2020
Degenerative disc diseases occupy the second place in the overall structure of morbidity with temporary disability. In 40% of patients with spinal osteochondrosis, diseases of the locomotor apparatus and connective tissue cause primary disability.
J. A. Bodnarchuk, M. V. Khyzhnjak, О. О. Potapov, N. G. Chopik   +3 more
doaj  

Roles of progenitor cells for intervertebral disc regeneration in "healer" mice [PDF]

, 2014
Student Oral Presentation Session 1INTRODUCTION: Intervertebral disc (IVD) degeneration is a major cause of back pain that can also lead to sciatica, affecting the quality of life. Current treatments are limited to salvage surgical operations. Biological
Chan, CW, Chan, D, Sskai, D, Xiong, C, Zhang, Y   +4 more
core   +1 more source

A mouse coccygeal intervertebral disc degeneration model with tail‐looping constructed using a suturing method

Animal Models and Experimental Medicine, EarlyView.
A novel, simple coccygeal intervertebral disc degeneration model, using a suturing method for tail‐looping, without the need for external fixation and complex surgery. The model has high reproducibility and stability and overcomes the disadvantages of the existing animal models of disc degeneration.
Wei Xie, Zemao Huang, Ziyang Huang, Deqing Luo, Zhangxin Chen, Li Xie, Lingqi Zhu, Hui Liu, Kejian Lian, Paolo Alberton, Denitsa Docheva, Dasheng Lin   +11 more
wiley   +1 more source

Inhibiting IL-1 signaling pathways to inhibit catabolic processes in disc degeneration [PDF]

, 2016
Intervertebral disc degeneration is characterized by an imbalance between catabolic and anabolic signaling, with an increase in catabolic cytokines particularly IL-1β, a key regulator of IVD degeneration.
Bachmeier, Binch, Chujo, Clarke, Holzberg, Hoyland, Jiang, Jobin, Karppinen, Klawitter, Kondo, Krejci, Le Maitre, Le Maitre, Le Maitre, Le Maitre, Le Maitre, Le Maitre, Le Maitre, Li, Liang, Lyss, Ma, Mwale, Nasto, Nerlich, Osuka, Paz Aparicio, Phillips, Phillips, Phillips, Risbud, Roughley, Seguin, Solovieva, Solovieva, Spagnoli, Studer, Studer, Sun, Sun, Tian, Tolonen, Ulrich, Wang, Wuertz, Yu, Zhongyi   +47 more
core   +1 more source