Results 131 to 140 of about 25,892 (278)

THROMBOSPONDIN IS A CRITICAL PATHOGENIC SIGNAL THAT PROMOTES FIBROSIS, ANGIOGENESIS AND NEURONAL SPROUTING DURING INTERVERTEBRAL DISC DEGENERATION [PDF]

Hannah Swahn, Jasmin Mertens, Kevin Myers, O. Alvarez-Garcia, Tony S. Mondala, Padmaja Natarajan, Steven R. Head, Martin Lotz   +7 more
openalex   +1 more source

Necrotizing Granulomas and Lytic Bone Lesions: Unmasking a Rare Presentation of Osseous Sarcoidosis in the Absence of Pulmonary Disease

ACR Open Rheumatology, Volume 8, Issue 1, January 2026.
Mikako Harata, Caitrin Coffey
wiley   +1 more source

Friedelin Ameliorates Nucleus Pulposus Inflammation by Increasing p65 Autophagic Degradation to Inhibit NF‐κB Signalling Pathway

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Intervertebral disc degeneration (IVDD) is a prevalent disorder associated with chronic inflammation, significantly affecting spinal health and general quality of life. This study examines the anti‐inflammatory properties of Friedelin (FD) and its impact on the NF‐κB signalling pathway in relation to IVDD.
Kewu Tu, Dongteng Liao, Zhaomou Chen, Zhenyu Wang, Kun Zhao, Hongyu Zhong, Shimin Wu, Huiyin Zhu, Jinming Xu, Beidi Zhou, Xiangheng Dai, Qiang Wu   +11 more
wiley   +1 more source

Resistin promotes CCL4 expression through toll-like receptor-4 and activation of the p38-MAPK and NF-κB signaling pathways: implications for intervertebral disc degeneration [PDF]

, 2016
Zhonghai Li, X. Wang, Hongbo Pan, Hao Yang, X. Li, Kai-Xin Zhang, H. Wang, Zhaomin Zheng, Haoran Liu, Jianru Wang   +9 more
openalex   +1 more source

Cartilage Endplate-Derived Stem Cells for Regeneration of Intervertebral Disc Degeneration: An Analytic Study

, 2023
Zhiwei Jia, Donghua Liu, Xingxuan Li, Tianlin Wen, Wei Li   +4 more
openalex   +2 more sources

Leptin Regulates Intervertebral Disc Calcification and Ossification by Promoting Glycolysis Through OCN/HIF‐1α Axis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT During intervertebral disc degeneration (IDD), cartilage endplate (CEP) cells undergo calcification and ossification, relying primarily on glycolysis for energy metabolism. Leptin (LEP) initiates the IDD, while its underlying mechanism related to glycolysis remains elusive in CEP cells. To investigate the underlying mechanism of LEP on IDD, an
Haoxi Li, Chengqiang Yu, Zhuhai Li, Shuyu Yao, Kaiqi Mo, Guanlu Peng, Yufeng Huang, Jianxun Wei   +7 more
wiley   +1 more source

Melatonin ameliorates intervertebral disc degeneration via the potential mechanisms of mitophagy induction and apoptosis inhibition [PDF]

, 2019
Yu Chen, Yanqing Wu, Hongxue Shi, Jianle Wang, Zengming Zheng, Jian Chen, Xi-Bang Chen, Zengjie Zhang, Daoliang Xu, Xiangyang Wang, Jian Xiao   +10 more
openalex   +1 more source

Transcriptomic and Functional Comparison of Cells Isolated From Healthy and Degenerated Ovine Intervertebral Discs

Journal of Cellular and Molecular Medicine, Volume 30, Issue 2, January 2026.
ABSTRACT Intervertebral disc degeneration (IVDD) is a leading cause of chronic low back pain, yet its cellular and molecular mechanisms remain incompletely understood. Sheep represent a valuable in vivo and ex vivo model for IVDD due to their anatomical and biomechanical similarities with humans and the possibility to access disc samples at early ...
Paul Humbert, Lucie Danet, Emmaëlle Carrot, Floriane Etienne, Boris Halgand, Frédéric Blanchard, Claire Vinatier, Jérôme Guicheux, Marion Fusellier, Catherine Le Visage, Romain Guiho   +10 more
wiley   +1 more source

[Retracted] Role of microRNA‑210 in human intervertebral disc degeneration

, 2023
Daying Zhang, Zhijian Wang, Yanbo Yu, Yong Zhang, Xuexue Zhang   +4 more
openalex   +2 more sources

Diagnosis of degenerative myelopathy in a Boston terrier–French bulldog mixed breed

Journal of Small Animal Practice, Volume 67, Issue 1, Page 86-91, January 2026.
Canine degenerative myelopathy (DM) has been associated with mutations in the superoxide dismutase 1 gene (SOD1). Although the SOD1:c.118G>A mutation has been identified in Boston terriers and French bulldogs, no histological‐confirmed degenerative myelopathy has been reported in either breed.
A. M. K. Chan, J. R. Coates, G. C. Johnson, H. N. Snyman, D. W. Silversides   +4 more
wiley   +1 more source