Results 141 to 150 of about 84,616 (318)

Degeneration of the intervertebral disc with new approaches for treating low back pain. [PDF]

, 2015
This review paper discusses the process of disc degeneration and the current understanding of cellular degradation in patients who present with low back pain.
Binch, AL, Hughes, SP, Le Maitre, CL, Thorpe, AA   +3 more
core  

Matrix modification for enhancing the transport properties of the human cartilage endplate to improve disc nutrition. [PDF]

, 2019
Poor solute transport through the cartilage endplate (CEP) impairs disc nutrition and could be a key factor that limits the success of intradiscal biologic therapies.
Dolor, Aaron, Fields, Aaron J, Lazar, Ann A, Lotz, Jeffrey C, Sampson, Sara L, Szoka, Francis C   +5 more
core   +2 more sources

Degeneration of Lumbar Intervertebral Discs: Characterization of Anulus Fibrosus Tissue and Cells of Different Degeneration Grades [PDF]

, 2020
Stefan Stich, Michal Jagielski, Anja Fleischmann, Carola Meier, Patricia Bußmann, Benjamin Kohl, Julia Schmidt, Jan‐Philipp Krüger, Michaela Endres, Mario Čabraja, Kolja Reimann, Dominik Laue, Wolfgang Ertel, Michael Sittinger   +13 more
openalex   +1 more source

Establishing a Staging System for Adjacent Segment Disease and Exploring Its Significance in Guiding Surgical Decisions: A Retrospective Study

Orthopaedic Surgery, Volume 17, Issue 5, Page 1418-1432, May 2025.
Developed a staging system for adjacent segment disease based on degeneration characteristics. Verified the feasibility and reliability of stage‐guided surgical decision‐making through surgical data, radiological data, and follow‐up data. This staging system was closely correlated with intervertebral disc degeneration and disc height while also ...
Changpeng Qu, Jianwei Guo, Hao Tao, Chuanli Zhou, Kai Zhu, Yihao Sun, Lei Li, Zhiming Liu, Hao Zhang, Xuexiao Ma   +9 more
wiley   +1 more source

BIOCHEMICAL AND BIOMECHANICAL SUBSTANTIATION OF REPARATIVE REGENERATION OF INTERVERTEBRAL DISCS IN PATIENTS WITH DEGENERATIVE DISC DISEASES

Східноукраїнський медичний журнал, 2020
Degenerative disc diseases occupy the second place in the overall structure of morbidity with temporary disability. In 40% of patients with spinal osteochondrosis, diseases of the locomotor apparatus and connective tissue cause primary disability.
J. A. Bodnarchuk, M. V. Khyzhnjak, О. О. Potapov, N. G. Chopik   +3 more
doaj  

Roles of progenitor cells for intervertebral disc regeneration in "healer" mice [PDF]

, 2014
Student Oral Presentation Session 1INTRODUCTION: Intervertebral disc (IVD) degeneration is a major cause of back pain that can also lead to sciatica, affecting the quality of life. Current treatments are limited to salvage surgical operations. Biological
Chan, CW, Chan, D, Sskai, D, Xiong, C, Zhang, Y   +4 more
core   +1 more source

Heterogeneity in Lumbar Segmental Bone Mineral Density and Age‐Related Evolution of Whole‐Body Bone Mineral Density: Comprehensive Implications for Osteoporosis Risk Assessment

Orthopaedic Surgery, EarlyView.
The BMDs of several body regions are associated with age and sex, with variations in the rate of change, age at first change, and age‐related trends depending on the anatomical site and sex. The BMDs of L1 and L2 are generally significantly lower than those of L3 and L4.
Jia‐Jun Zhang, Xiong‐Yi Wang, Cheng‐Wei Weng, Miao Zheng, You‐Jia Xu   +4 more
wiley   +1 more source

Advances in Comparative Medical Research on Anatomy and Histological Structure of Intervertebral Discs in Humans and Other Animals

Shiyan dongwu yu bijiao yixue
The 2023 China Health Report on Spine Degeneration noted a significant increase in lumbar surgery among patients under 35 years old in recent years, indicating a trend towards younger onset of cervical and lumbar diseases.
ZHANG Li, HAN Lingxia, KUANG Yu
doaj   +1 more source

Endogenous musculoskeletal tissue engineering - a focused perspective [PDF]

, 2012
Two major difficulties facing widespread clinical implementation of existing Tissue Engineering (TE) strategies for the treatment of musculoskeletal disorders are (1) the cost, space and time required for ex vivo culture of a patient’s autologous cells ...
Adam, Clayton
core   +2 more sources

Progress of Programmed Cell Death in Steroid‐Induced Osteonecrosis of the Femoral Head

Orthopaedic Surgery, EarlyView.
Steroid‐induced osteonecrosis of the femoral head is a severe osteoarticular condition resulting from glucocorticoid overuse, characterized by femoral head bone structure collapse and cell death, now predominant among nontraumatic femoral head necroses.
Zhi Kong, Chao Han
wiley   +1 more source