Results 141 to 150 of about 81,428 (351)

Discorpy: algorithms and software for camera calibration and correction

open access: yesJournal of Synchrotron Radiation, EarlyView.
Discorpy, a Python package for camera calibration, provides robust tools to independently correct radial and perspective distortion of varying strengths using a single calibration image.Camera or lens‐based detector calibration is essential for spatial accuracy in applications like dimensional tomography, optical metrology, and computer vision.
Nghia T. Vo
wiley   +1 more source

Oral Citrate Supplementation Mitigates Age‐Associated Pathologic Intervertebral Disc Calcification in LG/J Mice

open access: yesAging Cell, EarlyView.
An endochondral differentiation process in the CEPs drives pathologic disc calcification in aging LG/J mice, and NP cell hypertrophic transdifferentiation secondarily contributes. Supplementing drinking water with 80 mM K3Citrate during aging markedly reduced disc calcification, attenuated NP cell transdifferentiation, and mildly improved NP and AF ...
Olivia K. Ottone   +9 more
wiley   +1 more source

BRD4/MAP2K7/PGF Signaling Axis Promotes Senescence and Extracellular Matrix Metabolism of Nucleus Pulposus Cells in Intervertebral Disk Degeneration

open access: yesAging Cell, EarlyView.
This study identifies BRD4 as a key regulator in intervertebral disk degeneration (IDD), linking its upregulation to NP cell senescence and disrupted ECM metabolism through the BRD4/MAP2K7/PGF signaling cascade, offering a potential therapeutic target for IDD treatment.
Guangzhi Zhang   +6 more
wiley   +1 more source

Neural Network Surrogate and Projected Gradient Descent for Fast and Reliable Finite Element Model Calibration: a Case Study on an Intervertebral Disc [PDF]

open access: yes
Accurate calibration of finite element (FE) models is essential across various biomechanical applications, including human intervertebral discs (IVDs), to ensure their reliability and use in diagnosing and planning treatments. However, traditional calibration methods are computationally intensive, requiring iterative, derivative-free optimization ...
arxiv   +1 more source

Correlation of Early Outcomes and Intradiscal Interleukin-6 Expression in Lumbar Fusion Patients. [PDF]

open access: yes, 2020
OBJECTIVE: To determine if there is correlation between intradiscal levels of interleukin-6 (IL-6) and early outcome measures in patients undergoing lumbar fusion for painful disc degeneration.
Anderson, D Greg   +7 more
core   +1 more source

Pyrroloquinoline Quinone Reprograms the Single‐Cell Landscape of Immune Aging in Hematopoietic Immune System

open access: yesAging Cell, EarlyView.
This study demonstrates that aging induces oxidative stress and inflammation in the hematopoietic immune system, resulting in immune homeostasis dysfunction, including alterations in B cells and hematopoietic stem cells, senescent cells (SnCs) accumulation, and senescence‐associated secretory phenotypes (SASPs) production. Notably, the study highlights
Xiuxing Liu   +11 more
wiley   +1 more source

Degeneration and regeneration of the intervertebral disc: lessons from development

open access: yesDisease Models & Mechanisms, 2011
Degeneration of the intervertebral discs, a process characterized by a cascade of cellular, biochemical, structural and functional changes, is strongly implicated as a cause of low back pain.
Lachlan J. Smith   +4 more
doaj   +1 more source

Clinical Features of Seven COL2A1 Variations in Chinese Children With Type II Collagen Disorders

open access: yesActa Paediatrica, EarlyView.
ABSTRACTAimType II collagen, encoded by the collagen type II alpha 1 (COL2A1) gene, is crucial for the structure of cartilage. This study aims to improve our understanding of Spondyloepiphyseal Dysplasia Congenita (SEDC) caused by mutations in COL2A1.
Shumin Zhan   +8 more
wiley   +1 more source

Holistic Decomposition Convolution for Effective Semantic Segmentation of 3D MR Images [PDF]

open access: yesarXiv, 2018
Convolutional Neural Networks (CNNs) have achieved state-of-the-art performance in many different 2D medical image analysis tasks. In clinical practice, however, a large part of the medical imaging data available is in 3D. This has motivated the development of 3D CNNs for volumetric image segmentation in order to benefit from more spatial context.
arxiv  

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