Results 161 to 170 of about 84,616 (318)

The Role of miR-31-5p in the Development of Intervertebral Disc Degeneration and Its Therapeutic Potential

, 2021
Yong Zhou, Mingsi Deng, Jiqing Su, Wei Zhang, Dongbiao Liu, Zhengguang Wang   +5 more
openalex   +1 more source

Epigenetic modifications of inflammation in intervertebral disc degeneration

Ageing Research Reviews, 2023
Liang Kang, Huaqing Zhang, Chongyu Jia, Renjie Zhang, Cailiang Shen   +4 more
semanticscholar   +1 more source

Leptin Regulates Intervertebral Disc Calcification and Ossification by Promoting Glycolysis Through OCN/HIF‐1α Axis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT During intervertebral disc degeneration (IDD), cartilage endplate (CEP) cells undergo calcification and ossification, relying primarily on glycolysis for energy metabolism. Leptin (LEP) initiates the IDD, while its underlying mechanism related to glycolysis remains elusive in CEP cells. To investigate the underlying mechanism of LEP on IDD, an
Haoxi Li, Chengqiang Yu, Zhuhai Li, Shuyu Yao, Kaiqi Mo, Guanlu Peng, Yufeng Huang, Jianxun Wei   +7 more
wiley   +1 more source

Zhiqiao Gancao decoction regulated JAK2/STAT3/ macrophage M1 polarization to ameliorate intervertebral disc degeneration

Heliyon
Background: Zhiqiao Gancao decoction (ZQGCD) was created by Professor Gong Zhengfeng, a renowned Chinese medicine expert. Clinical studies have shown its efficacy in alleviating pain and enhancing lumbar function in intervertebral disc degeneration (IDD)
Zeling Huang, Xiaofeng Shen, Hua Chen, Zaishi Zhu, Binjie Lu, Long Zhang, Yujiang Liu, Yuwei Li, Bo Xu   +8 more
doaj   +1 more source

Degeneration and regeneration of the intervertebral disc: lessons from development

Disease Models & Mechanisms, 2011
Degeneration of the intervertebral discs, a process characterized by a cascade of cellular, biochemical, structural and functional changes, is strongly implicated as a cause of low back pain.
Lachlan J. Smith, Nandan L. Nerurkar, Kyung-Suk Choi, Brian D. Harfe, Dawn M. Elliott   +4 more
doaj   +1 more source

Cellular senescence - Molecular mechanisms of intervertebral disc degeneration from an immune perspective.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023
Chao Song, Yan Zhou, K. Cheng, Fei Liu, Weiye Cai, Daqian Zhou, Rui Chen, Houyin Shi, Zhi-jiang Fu, Jingwen Chen, Zongchao Liu   +10 more
semanticscholar   +1 more source

The Implementation of Persistent Spinal Pain Syndrome (PSPS): Mechanism‐Based Recommendations

Pain Practice, Volume 26, Issue 1, January 2026.
ABSTRACT Background In 2021, the term persistent spinal pain syndrome (PSPS) was introduced. PSPS type 2 (PSPS‐T2) replaced the unsatisfactory term failed back surgery syndrome (FBSS). PSPS type 1 (PSPS‐T1) is a clinical picture of signs and symptoms of FBSS but without prior surgery. PSPS applies to any spinal level.
Simon Thomson, Brian Simpson, Frank J. Huygen, Michael Stanton‐Hicks, Richard B. North, Giancarlo Barolat, Harriet Scott, Rui V. Duarte   +7 more
wiley   +1 more source

Correlation of Early Outcomes and Intradiscal Interleukin-6 Expression in Lumbar Fusion Patients. [PDF]

, 2020
OBJECTIVE: To determine if there is correlation between intradiscal levels of interleukin-6 (IL-6) and early outcome measures in patients undergoing lumbar fusion for painful disc degeneration.
Anderson, D Greg, Antonacci, Christopher L, Kepler, Chris K, Koerner, John D, Markova, Dessislava Z, Mendelis, Joseph, Schroeder, Greg D, Vaccaro, Alexander R   +7 more
core   +1 more source

MRI Signal Void in Degenerated Canine Intervertebral Disks May Represent Mineralization or Gas

Veterinary Radiology &Ultrasound, Volume 67, Issue 1, January 2026.
ABSTRACT Accurate interpretation of intradiskal signal voids on magnetic resonance imaging (MRI) is essential to avoid misdiagnosis and improve diagnostic decision‐making in canine spinal imaging. Gas accumulation within the degenerated canine intervertebral disk (IVD), known as vacuum phenomenon (VP), and IVD mineralization are common findings in ...
Yasamin Vali, Carola Daniel, Eberhard Ludewig, Tobias Schwarz   +3 more
wiley   +1 more source

Degeneration of the Intervertebral Disc in the Cat [PDF]

Acta Orthopaedica Scandinavica, 1964
A S, KING, R N, SMITH
openaire   +2 more sources