Results 161 to 170 of about 38,647 (321)

Exploring extracellular vesicles as novel therapeutic agents for intervertebral disc degeneration: delivery, applications, and mechanisms

Stem Cell Research & Therapy
Intervertebral disc degeneration is a multifactorial degenerative disease that poses a significant threat to the health of the elderly population. Current treatments primarily focus on physical therapy, medication, and surgery to alleviate symptoms ...
Yuxin Jin, Ouqiang Wu, Zhihua Chen, Linjie Chen, Kai Zhang, Qizhu Chen, Haijun Tian, Xinzhou Wang, Morgan Jones, Kenny Yat Hong Kwan, Yan Michael Li, Pooyan Makvandi, Xiangyang Wang, Xiang Hai, Jun Zhang, Aimin Wu   +15 more
doaj   +1 more source

Animal Models of Disc Degeneration Using Puncture Injury: A 20 Year Perspective

JOR SPINE, Volume 8, Issue 3, September 2025.
This review of surgically induced IVD puncture injury animal models presents an evolution over decades to include many variations simulating distinct clinical phenotypes of IVDD, and recommends reporting a common set of injury features to facilitate cross‐study comparison.
Charu Jain, Jonathan J. Huang, Yunsoo Lee, Saad Chaudhary, Andrew C. Hecht, Alon Lai, Koichi Masuda, James Kang, James C. Iatridis   +8 more
wiley   +1 more source

Polyethylene microplastics promote nucleus pulposus cell senescence by inducing oxidative stress via TLR4/NOX2 axis

Ecotoxicology and Environmental Safety
This study aimed to detect and characterize microplastics in intervertebral disc and investigate their effects and molecular mechanism on intervertebral disc degeneration.
Weilin Zhang, Zhencong Li, Zhongwei Wang, Kuize Liu, Shengbang Huang, Jinguo Liang, Zhiwen Dai, Weixiong Guo, Chao Mao, Siyuan Chen, Jinsong Wei   +10 more
doaj  

Effect of Vertebral Body Tether Tensioning on Vertebral Body Growth Modulation

JOR SPINE, Volume 8, Issue 3, September 2025.
Intraoperative intervertebral tensioning significantly affects vertebral body growth over 2 years. Greater tension resulted in less vertebral body growth and greater differential growth. Further studies would benefit from better methods to quantify forces applied during surgery.
Taylor J. Jackson, Craig Louer, Ron El‐Hawary, Jennifer Hurry, Hui Nian, Christine Farnsworth, Carrie E. Bartley, Tracey P. Bryan, Michael P. Kelly, Peter O. Newton, Stefan Parent, Pediatric Spine Study Group, Vidyadhar V. Upasani   +12 more
wiley   +1 more source

Zhiqiao Gancao decoction regulated JAK2/STAT3/ macrophage M1 polarization to ameliorate intervertebral disc degeneration

Heliyon
Background: Zhiqiao Gancao decoction (ZQGCD) was created by Professor Gong Zhengfeng, a renowned Chinese medicine expert. Clinical studies have shown its efficacy in alleviating pain and enhancing lumbar function in intervertebral disc degeneration (IDD)
Zeling Huang, Xiaofeng Shen, Hua Chen, Zaishi Zhu, Binjie Lu, Long Zhang, Yujiang Liu, Yuwei Li, Bo Xu   +8 more
doaj  

The involvement of aggrecan polymorphism in degeneration of human intervertebral disc and articular cartilage

, 2006
Peter J. Roughley, Dirk E. Martens, Juho Rantakokko, Mauro Alini, F. Mwale, John Antoniou   +5 more
openalex   +1 more source

Biological Sex Is Under‐Reported in Cartilage‐Related Preclinical Research: A Cross‐Sectional Analysis

JOR SPINE, Volume 8, Issue 3, September 2025.
This study highlights the significant under‐reporting of donor sex in preclinical research related to intervertebral disc degeneration (IDD) and osteoarthritis (OA). We found that only 61.9% of the examined articles reported donor sex, with a predominance of male samples, and sex was rarely considered in outcome analyses.
Daniele Zuncheddu, Paola Buedo, Martin J. Stoddart, Laura B. Creemers, Sibylle Grad, Marcin Waligora   +5 more
wiley   +1 more source

Relationship Between Quantitative MRI and Radiological, Histological, and Biochemical Measures of Intervertebral Disc Health in Client‐Owned, Nonchondrodystrophic‐Breed Dogs

JOR SPINE, Volume 8, Issue 3, September 2025.
The purpose of this study was to assess the sensitivity of quantitative MRI techniques in detecting disc degeneration in client‐owned, nonchondrodystrophic‐breed dogs. Thoracolumbar vertebral columns from the donated bodies of 15 dogs without a history of IVDD were imaged ex vivo at 3T MRI, and quantitative MRI values of the discs were compared to ...
Alaina L. Falck, Erick O. Buko, Kayla L. Chase, Diana Pendleton, Katie McDermott, Olivia Kim, Suhail P. Parvaze, Alexandra R. Armstrong, Susan A. Arnold, Elizabeth W. Bradley, Arin M. Ellingson, Christopher P. Ober, Aaron Rendahl, Casey P. Johnson   +13 more
wiley   +1 more source

31 EVALUATION OF INTERVERTEBRAL DISC AND VERTEBRAL ENDPLATE DEGENERATION IN ADAMTS5 (AGGRECANASE-2) KNOCKOUT MICE

, 2007
J. Chen, Lawrence M. Boyd, Kyle D. Allen, Melissa Tsuboyama, L. Jing, Anne‐Marie Malfait, Lori A. Setton   +6 more
openalex   +1 more source

Mesenchymal Stem Cell for Prevention and Management of Intervertebral Disc Degeneration [PDF]

, 2012
Umile Giuseppe Longo, Nicola Papapietro, Stefano Petrillo, Edoardo Franceschetti, Nicola Maffulli, Vincenzo Denaro   +5 more
openalex   +1 more source