Results 181 to 190 of about 38,647 (321)

The cytokine and chemokine expression profile of nucleus pulposus cells: implications for degeneration and regeneration of the intervertebral disc [PDF]

, 2013
K. L. E. Phillips, N Chiverton, Anthony L.R. Michael, Ashley Cole, Lee Breakwell, Gail Haddock, R.A.D. Bunning, Alison K. Cross, Christine L. Le Maitre   +8 more
openalex   +1 more source

14. Discogenic Low Back Pain

Pain Practice, Volume 25, Issue 7, September 2025.
ABSTRACT Introduction Discogenic low back pain can be severely disabling, clinically challenging to diagnose, and expensive to treat. Disc degeneration is characterized by disc dehydration, which diminishes the ability of the disc to distribute pressure, making it more susceptible to damage, and leading to annular tears, fissures, and a higher ...
Wouter K. M. van Os, Ricardo Alvarez‐Jimenez, Steven P. Cohen, Milan P. Stojanovic, Ricardo Ruiz‐Lopez, Jan Van Zundert, Jan Willem Kallewaard   +6 more
wiley   +1 more source

Clinical characterization of thoracolumbar and lumbar intervertebral disk extrusions in English Cocker Spaniels [PDF]

, 2016
Aikawa T, Braund KG, Brown NO, Caitlin E. Tzounos, Dewey CW, Goggin JE, Holger A. Volk, Mogensen MS, Ruddle TL, Steven De Decker, Thomas J.A. Cardy   +10 more
core   +1 more source

Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration [PDF]

, 2013
Nam V. Vo, Robert A. Hartman, Takashi Yurube, Lloydine J. Jacobs, Gwendolyn Sowa, James D. Kang   +5 more
openalex   +1 more source

Decoding Pain: Next‐Generation In Vitro Systems for Mechanistic Insights and Drug Discovery

The FASEB Journal, Volume 39, Issue 16, 31 August 2025.
Developing an in vitro pain model that mimics essential features of the in vivo pain circuit requires careful consideration of multiple components and choices. These include selecting the cellular population for the model, choosing from the origin of nociceptors and other cells that are cultured, deciding between 3D or 2D dimensions, designing the ...
Dara Khosrowshahi, Liesbet Lagae, Johanna Bolander   +2 more
wiley   +1 more source

Tissue engineering strategies for treating intervertebral disc degeneration. [PDF]

Front Bioeng Biotechnol
Nie G, Liu W, Zeng F, Hu J, Wang Z, Huang Z, Chen H, Hu J, Xu J.   +8 more
europepmc   +1 more source

Injection of human umbilical tissue–derived cells into the nucleus pulposus alters the course of intervertebral disc degeneration in vivo [PDF]

, 2013
Steven Leckie, Gwendolyn Sowa, Bernard Bechara, Robert A. Hartman, J. Paulo Coelho, William T. Witt, Qing Dong, Brent W. Bowman, Kevin M. Bell, Nam V. Vo, Brian C. Kramer, James D. Kang   +11 more
openalex   +1 more source

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

A Bibliometric Study of Interleukin Cytokines in the Treatment of Intervertebral Disc Degeneration. [PDF]

Drug Des Devel Ther
Wang H, Li X, Wang S, Liu J, Xie N.
europepmc   +1 more source

Sex Differences in Frailty in Milan Over the Last 2000 Years: A Hazards‐Based and Cumulative Phenotype Approach

American Journal of Biological Anthropology, Volume 187, Issue 4, August 2025.
ABSTRACT Objectives Frailty in bioarchaeology has garnered increasing interest in recent decades, particularly for analyzing and comparing past health across different groups and populations. A hazards‐based cumulative phenotype approach was applied to 492 adult males and females from five consecutive historical periods in the city of Milan: Roman (2nd–
Lucie Biehler‐Gomez, Kathryn E. Marklein, Samantha L. Yaussy, Douglas E. Crews, Sharon N. DeWitte, Cristina Cattaneo   +5 more
wiley   +1 more source