Results 221 to 230 of about 40,769 (270)

Genetics of Intervertebral Disc Degeneration

Current Osteoporosis Reports, 2023
Intervertebral disc degeneration is a contributor to chronic back pain. While a part of the natural aging process, early or rapid intervertebral disc degeneration is highly heritable. In this review, we summarize recent progress towards unraveling the genetics associated with this degenerative process.Use of large cohorts of patient data to conduct ...
David C. Ou-Yang, Christopher J. Kleck, Cheryl L. Ackert-Bicknell   +2 more
openaire   +2 more sources

Fundamentals of Intervertebral Disc Degeneration

World Neurosurgery, 2022
Lumbar disc degeneration is one of the leading causes of chronic low back pain. The degenerative cascade is often initiated by an imbalance between catabolic and anabolic processes in the intervertebral discs. As a consequence of extracellular matrix degradation, neoinnervation and neovascularization take place.
Sertac Kirnaz, Charisse Capadona, Taylor Wong, Jacob L. Goldberg, Branden Medary, Fabian Sommer, Lynn B. McGrath, Roger Härtl   +7 more
openaire   +2 more sources

Intervertebral disc degeneration

European Spine Journal, 1993
Disc degeneration in the human spine is a complex phenomenon characterised by biochemical change in the nucleus pulposus and inner annulus and the formation of clefts and fissures radiating from the central area of the disc towards the periphery. In addition, and probably independent of these phenomena, discrete defects in the outer annular attachement
Barrie Vernon-Roberts, Robert D. Fraser, O. L. Osti   +2 more
openaire   +3 more sources

Smoking and intervertebral disc degeneration

Medical Hypotheses, 2001
Cigarette smokers have an increased risk of low back pain which may be caused by disc degeneration and spinal instability, for example. Ischemia, apoptosis, faulty synthesis of disc macromolecules, and an imbalance between disc matrix proteinases and their inhibitors may be involved in the pathogenesis of disc degeneration. Along with degeneration, the
R.R. Fogelholm, A.V.Alho
openaire   +3 more sources

Genetics of the Degenerated Intervertebral Disc

World Neurosurgery, 2012
Given the genetic and proteomic advances of the past decade, understanding of the molecular etiopathogenesis of several complex diseases is increasing. Intervertebral disc disease (IVDD) is no different from other complex diseases where both environmental and genetic constituents are considered causes.
Nikolay L. Martirosyan, Guy G. Broc, Nicholas Theodore, Samuel Kalb, M. Yashar S. Kalani   +4 more
openaire   +3 more sources

Intervertebral disc degeneration in the dog. Part 1: Anatomy and physiology of the intervertebral disc and characteristics of intervertebral disc degeneration

The Veterinary Journal, 2013
Intervertebral disc (IVD) degeneration is common in dogs and can give rise to a number of diseases, such as IVD herniation, cervical spondylomyelopathy, and degenerative lumbosacral stenosis. Although there have been many reports and reviews on the clinical aspects of canine IVD disease, few reports have discussed and reviewed the process of IVD ...
Ragnvi Hagman, Anne-Sofie Lagerstedt, Guy C. M. Grinwis, Niklas Bergknut, Marianna A. Tryfonidou, Björn P. Meij, Lucas A. Smolders, Herman A.W. Hazewinkel   +7 more
openaire   +3 more sources

Imaging Intervertebral Disc Degeneration

Journal of Bone and Joint Surgery, 2006
Magnetic resonance imaging provides excellent anatomic detail of spinal tissues, but fails to provide the type of information that permits a definitive diagnosis in many patients with back pain. New imaging strategies that can be applied to the study of intervertebral disc degeneration include diffusion-weighted imaging, magnetic resonance imaging ...
openaire   +3 more sources

Mechanobiology of the Intervertebral Disc and Relevance to Disc Degeneration

Journal of Bone and Joint Surgery, 2006
Mechanical loading of the intervertebral disc may contribute to disc degeneration by initiating degeneration or by regulating cell-mediated remodeling events that occur in response to the mechanical stimuli of daily activity. This article is a review of the current knowledge of the role of mechanical stimuli in regulating intervertebral disc cellular ...
Lori A. Setton, Jun Chen
openaire   +2 more sources