Results 221 to 230 of about 81,428 (351)

Analysis of Nicotine Toxicity and Mechanisms of Senescence in Nucleus Pulposus Cells Using Network Toxicology and Molecular Docking Technique

JOR SPINE, Volume 8, Issue 2, June 2025.
The current study improves cyber toxicology as a method of evaluating environmental toxicity and molecular biological qualities in addition to clarifying the possible molecular pathways of nicotine‐induced senescence in IVDD. ABSTRACT Aim Through the use of network toxicology, the research sought to determine whether cellular senescence and associated ...
Chen Jiang, Chao Song, Chaoqi Chen, Baoxin Shen, Lei Yang, Chi Zhang, Fei Liu, Xiaofei Wu, Feng Chen   +8 more
wiley   +1 more source

Exploring the molecular mechanisms underlying intervertebral disc degeneration by analysing multiple datasets. [PDF]

Sci Rep
Lin L, Li D, Cai G, Zheng G, Huang D, Liu H, Lin S, Zhao F.   +7 more
europepmc   +1 more source

Simulation of the Progression of Intervertebral Disc Degeneration Due to Decreased Nutritional Supply [PDF]

, 2014
Weiyong Gu, Qiaoqiao Zhu, Xin Gao, Mark D. Brown   +3 more
openalex   +1 more source

Phosphatidylethanolamine Protects Nucleus Pulposus Cells From Oxidative Stress‐Induced Cellular Senescence and Extracellular Matrix Degradation by Promoting Autophagy

JOR SPINE, Volume 8, Issue 2, June 2025.
In this study, we utilized LC/MS‐based untargeted metabolomics analysis to examine changes in the metabolite profiles of NP cells under stress conditions. Upon analysis, PE was identified as a differentially abundant metabolite for its decreased content within advanced‐stage NP cells.
Yijun Dong, Chuanfu Li, Shuangshuang Tu, Mingkai Liu, Kai Lv, Liqun Duan, Feng Zhang, Haiping Cai, Xi Chen, Wenzhi Zhang   +9 more
wiley   +1 more source

Molecular Mechanisms of Intervertebral Disc Degeneration Induced by <i>Propionibacterium acnes</i>. [PDF]

Biomed Res Int
Yang W, Xu Y, Tan Y, Lin J, Chen H, Li S, Miao H, Ye D.   +7 more
europepmc   +1 more source

I-22 LINKS BETWEEN INTERVERTEBRAL DISC DEGENERATION AND OA

, 2010
J Urban
openalex   +1 more source

Macrophage Changes and High‐Throughput Sequencing in Aging Mouse Intervertebral Disks

JOR SPINE, Volume 8, Issue 2, June 2025.
We aimed to evaluate caudal IVD specimens from adult and older mice to study M0, M1, and M2 macrophage polarization and their aging‐related secretory phenotypes. Additionally, we aimed to assess macrophage polarization in aged disks, along with the differential expression of genes related to aging, and the hub genes involved in aging.
Wei Wang, Cheng Jiang, Jiong‐Hui Chen, Yong‐Long Chen, Zhen‐Wu Zhang, Zhi‐Chao Yang, Jun Li, Xiao‐Chuan Li   +7 more
wiley   +1 more source

LGR6 modulates intervertebral disc degeneration through regulation of macrophage efferocytosis. [PDF]

J Transl Med
Li F, Shi Y, Chen J, Sun J, Shi J, Sun K, Zheng B.   +6 more
europepmc   +1 more source

513 DEGENERATION OF INTERVERTEBRAL DISC: CORRELATION BETWEEN MRI HISTOLOGICAL AND TRANSCRIPTS ANALYSIS

, 2010
Johann Clouet, Marianne Pot-Vaucel, Claire Vinatier, Martial Masson, Julie Lesoeur, Yan Chérel, Lydie Guigand, Marion Fusellier, B. Fellah, O. Gauthier, Pierre Weiss, G. Grimandi, Jérôme Guicheux   +12 more
openalex   +1 more source

CCL3 correlates with ferroptosis in intervertebral disc degeneration and its prognostic significance. [PDF]

Sci Rep
Chen H, Xu P, Mao L, Wang Y, Feng Z, Wang Z, Shen C, Xu Y.   +7 more
europepmc   +1 more source