Results 221 to 230 of about 25,892 (278)

Corrigendum to "m6A hypomethylation of DNMT3B regulated by ALKBH5 promotes intervertebral disc degeneration via E4F1 deficiency". [PDF]

Clin Transl Med
europepmc   +1 more source

Acid-sensing ion channel 1a contributes to the calcium/calmodulin-dependent ferroptosis and aggravates intervertebral disc degeneration. [PDF]

Redox Rep
Zhou LP, Wang JQ, Kang L, Hou YX, Yan X, Zhao CH, Jia CY, Zhang HQ, Zhang RJ, Shen CL.   +9 more
europepmc   +1 more source

Causal effect of education on low back pain, intervertebral disc degeneration and sciatica: Mendelian randomization study. [PDF]

Future Sci OA
Wu Z, Gong Y, Long H, Deng R, He J, Su M, Wang J, Gong K.   +7 more
europepmc   +1 more source

Senescent cartilage endplate stem cells-derived exosomes induce oxidative stress injury in nucleus pulposus cells and aggravate intervertebral disc degeneration by regulating FOXO3

Zan Bian, Yu Zhai, Yuyao Zhang, Tianling Wang, Hao Li, Jian Ouyang, Chao Liu, Siya Wang, Zhilei Hu, Xian Chang, Chao Zhang, Minghan Liu, Changqing Li   +12 more
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A Bibliometric Study of Interleukin Cytokines in the Treatment of Intervertebral Disc Degeneration. [PDF]

Drug Des Devel Ther
Wang H, Li X, Wang S, Liu J, Xie N.
europepmc   +1 more source

Impact of metformin on intervertebral disc degeneration in patients with diabetes: a prospective cohort study from the UK biobank. [PDF]

Diabetol Metab Syndr
Chen J, Liao N, Gao B, Liang T, Hu W, Zhang Z, Choi W, Shi H, Liu S, Chen Y, Lin Y, Deng Z, Qiu X, Huang D, Gao W.   +14 more
europepmc   +1 more source

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Genetics of Intervertebral Disc Degeneration

Current Osteoporosis Reports, 2023
Intervertebral disc degeneration is a contributor to chronic back pain. While a part of the natural aging process, early or rapid intervertebral disc degeneration is highly heritable. In this review, we summarize recent progress towards unraveling the genetics associated with this degenerative process.Use of large cohorts of patient data to conduct ...
David C. Ou-Yang, Christopher J. Kleck, Cheryl L. Ackert-Bicknell   +2 more
openaire   +2 more sources

Fundamentals of Intervertebral Disc Degeneration

World Neurosurgery, 2022
Lumbar disc degeneration is one of the leading causes of chronic low back pain. The degenerative cascade is often initiated by an imbalance between catabolic and anabolic processes in the intervertebral discs. As a consequence of extracellular matrix degradation, neoinnervation and neovascularization take place.
Sertac Kirnaz, Charisse Capadona, Taylor Wong, Jacob L. Goldberg, Branden Medary, Fabian Sommer, Lynn B. McGrath, Roger Härtl   +7 more
openaire   +2 more sources

Epigenetic regulation in intervertebral disc degeneration

Trends in Molecular Medicine, 2022
Intervertebral disc (IVD) degeneration is the leading cause of low back pain, which has a striking impact on numerous patients. Therefore, comprehensively illuminating the regulatory mechanisms of IVD degeneration is of great significance. Here, we discuss the latest advances in understanding the main epigenetic mechanisms regulating IVD degeneration.
Gaocai Li, Weifeng Zhang, Huaizhen Liang, Cao Yang   +3 more
openaire   +2 more sources