Results 61 to 70 of about 38,647 (321)

TWEAK and TSLP in disc degeneration and spontaneous hernia resorption

JOR Spine, 2020
Spontaneous degeneration of an intervertebral disc is caused by inflammation that accompanies exposure of the avascular nucleus pulposus to circulation, triggering an autoimmune inflammatory reaction.
Tetsuro Ohba, Hirotaka Haro
doaj   +1 more source

Integrated transcriptome and proteome analyses identify novel regulatory network of nucleus pulposus cells in intervertebral disc degeneration

BMC Medical Genomics, 2021
Background Degeneration of intervertebral disc is a major cause of lower back pain and neck pain. Studies have tried to unveil the regulatory network using either transcriptomic or proteomic analysis.
Chen Xu, Shengchang Luo, Leixin Wei, Huiqiao Wu, Wei Gu, Wenchao Zhou, Baifeng Sun, Bo Hu, Hongyu Zhou, Yang Liu, Huajiang Chen, Xiaojian Ye, Wen Yuan   +12 more
doaj   +1 more source

Association of COL2A1rs2276454, rs1793953, COL9A1rs1135056, COL11A1rs1676486 structure-forming collagens of the nucleus pulposus with degeneration of intervertebral discs L5-L4, L5-S1

Patologìâ, 2023
Aim. The purpose of the work was to determine the relationship between degenerative changes of the L5-S1 and L4-L5 intervertebral discs with collagen mononucleotide variants COL2A1rs2276454, rs1793953, COL9A1rs1135056, COL11A1rs1676486 among ethnic ...
Ye. H. Pedachenko, I. H. Vasylieva, M. V. Khyzhniak, O. S. Halanta, N. H. Chopyk, O. I. Tsiubko, A. B. Hriazov, O. S. Nekhlopochyn, T. A. Ksenzov, A. B. Dmytrenko, T. A. Makarova   +10 more
doaj   +1 more source

Cell therapy for the degenerating intervertebral disc [PDF]

Translational Research, 2017
Spinal conditions related to intervertebral disc (IVD) degeneration cost billions of dollars in the US annually. Despite the prevalence and soaring cost, there is no specific treatment that restores the physiological function of the diseased IVD. Thus, it is vital to develop new treatment strategies to repair the degenerating IVD.
Neil R. Malhotra, Lachlan J. Smith, Motomi Enomoto-Iwamoto, Robert L. Mauck, Yejia Zhang, Yejia Zhang, Franklin E. Caldera, Wei Tong, Zhouyu Lu, Harvey E. Smith, Ling Qin, Martin F. Heyworth   +11 more
openaire   +3 more sources

USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study identifies USP10 as a novel deubiquitinase that antagonizes ferroptosis in head and neck squamous cell carcinoma (HNSCC). Mechanistically, USP10 directly stabilizes POLR2A protein through post‐translational deubiquitination, enabling POLR2A‐mediated transcriptional activation of SLC7A11, a key ferroptosis inhibitor.
Diekuo Zhang, Xueying Wang, Shanhong Lu, Yan Gao, Gangcai Zhu, Guo Li, Zongnan Yu, Junwei Hou, Helei Yan, Wenhui Yuan, Xin Zhang, Mien‐Chie Hung, Zhifeng Liu, Yong Liu   +13 more
wiley   +1 more source

Finite Element Analysis of Stress Distribution and Range of Motion in Discogenic Back Pain [PDF]

Neurospine
Objective Precise knowledge regarding the mechanical stress applied to the intervertebral disc following each individual spine motion enables physicians and patients to understand how people with discogenic back pain should be guided in their exercises ...
Pyung-Goo Cho, Seon-Jin Yoon, Dong Ah Shin, Min Cheol Chang   +3 more
doaj   +1 more source

TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo

Arthritis Research & Therapy, 2023
Background Intervertebral disc degeneration (IDD) is one of the most common disorders related to the spine. Inflammation, apoptosis and extracellular matrix (ECM) degradation contribute to disc degeneration in nucleus pulposus cells (NPCs).
Kun Wang, Dengbo Yao, Yuxi Li, Ming Li, Weike Zeng, Zhuangyao Liao, Engming Chen, Shixin Lu, Kaihui Su, Zhen Che, Yuwei Liang, Peng Wang, Lin Huang   +12 more
doaj   +1 more source

Content Analysis of General Practitioner Requested Lumbar Spine X-ray Reports [PDF]

, 2007
Aims and Background X-rays of patients with low back pain rarely show serious pathology but frequently reveal incidental age-related changes and always expose people to radiation.
Carr, Eloise C.J., Thompson, Paul W.
core   +1 more source

Structure, Mechanics, and Mechanobiology of Fibrocartilage Pericellular Matrix Mediated by Type V Collagen

Advanced Science, EarlyView.
This study defines the structure, mechanics, and mechanobiology of the fibrocartilage pericellular matrix (PCM) using the murine meniscus, showing how collagen V deficiency alters PCM properties and disrupts cell mechanosensitive signaling. Findings emphasize the critical role of PCM in fibrocartilage mechanobiology and suggest targeting it can enhance
Chao Wang, Mingyue Fan, Su Chin Heo, Sheila M. Adams, Thomas Li, Yuchen Liu, Qing Li, Claudia Loebel, Jason A. Burdick, X. Lucas Lu, David E. Birk, Farid Alisafaei, Robert L. Mauck, Lin Han   +13 more
wiley   +1 more source

STUDIES OF MOLECULAR CHANGES IN INTERVERTEBRAL DISC DEGENERATION IN ANIMAL MODEL [PDF]

Acta Ortopédica Brasileira, 2016
Objective: To evaluate the structural and molecular changes in the extracellular matrix (ECM) during the process of intervertebral disc degeneration, using animal model.
Marcelo Ferraz de Campos, Cintia Pereira de Oliveira, Charles Benjamin Neff, Olga Maria de Toledo Correa, Maria Aparecida Silva Pinhal, Luciano Miller Reis Rodrigues   +5 more
doaj   +2 more sources