Results 61 to 70 of about 84,616 (318)

NF‐κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration

Cell Proliferation, 2021
Intervertebral disc degeneration (IDD) is a common clinical degenerative disease of the spine. A series of factors, such as inflammation, oxidative stress and mechanical stress, promote degradation of the extracellular matrix (ECM) of the intervertebral ...
Guangzhi Zhang, Ming-Qiang Liu, Haiwei Chen, Zuolong Wu, Yicheng Gao, Zhanjun Ma, Xuegang He, X. Kang   +7 more
semanticscholar   +1 more source

FGF4 retrogene on CFA12 is responsible for chondrodystrophy and intervertebral disc disease in dogs. [PDF]

, 2017
Chondrodystrophy in dogs is defined by dysplastic, shortened long bones and premature degeneration and calcification of intervertebral discs. Independent genome-wide association analyses for skeletal dysplasia (short limbs) within a single breed ...
Aguilar, Miriam, Bannasch, Danika L, Brown, C Titus, Brown, Emily A, Dickinson, Peter J, Ettinger, Cassandra L, Korff, Courtney, Lind, Jenna, Mansour, Tamer, Pollard, Rachel, Raudsepp, Terje, Sturges, Beverly K, Varon, Samuel, Young, Amy E   +13 more
core   +2 more sources

Altered Metabolism and Inflammation Driven by Post-translational Modifications in Intervertebral Disc Degeneration

Research
Intervertebral disc degeneration (IVDD) is a prevalent cause of low back pain and a leading contributor to disability. IVDD progression involves pathological shifts marked by low-grade inflammation, extracellular matrix remodeling, and metabolic ...
Dingchao Zhu, Huaizhen Liang, Zhi Du, Qian Liu, Gaocai Li, Weifeng Zhang, Di Wu, Xingyu Zhou, Yu Song, Cao Yang   +9 more
semanticscholar   +1 more source

Allogeneic fibroblasts ameliorate intervertebral disc degeneration by reducing osteophytes in rabbits

Frontiers in Medicine
IntroductionLow back pain (LBP) was commonly induced by intervertebral disc degeneration (IVDD), which is accompanied by the loss of disc height and osteophyte generation.
Chen Chen, Yizhuo Huang, Lei Shi, Li Zhou, Shenao Zhou, Shenao Zhou, Hongjin Wan, Xiao Yang, Jie Zhao   +8 more
doaj   +1 more source

An in‐depth analysis of the immunomodulatory mechanisms of intervertebral disc degeneration

JOR Spine, 2022
Intervertebral disc degeneration (IVDD) is the pathological basis of disc herniation, spinal stenosis, and other related diseases, and the lower back pain it produces lays a heavy financial burden on individuals and society.
Chao Song, Weiye Cai, Fei Liu, K. Cheng, Daru Guo, Zongchao Liu   +5 more
semanticscholar   +1 more source

Prevalence and Risk Factors for Presumptive Ascending/Descending Myelomalacia in Dogs after Thoracolumbar Intervertebral Disk Herniation [PDF]

, 2017
Background: Ascending/descending myelomalacia (ADMM) is a severe complication of thoracolumbar intervertebral disk herniation (TL-IVDH) in dogs. Hypothesis/Objectives: To investigate the prevalence and risk factors for ADMM in nonambulatory dogs with ...
Aikawa, Amsellem, Bergknut, Bezuidenhout, Boekhoff, Ferreira, Fingeroth, Griffiths, Henke, Henke, Ito, Jeffery, Jeffery, Kato, Kranenburg, Lahunta, Laitinen, Levine, Lu, Marquis, Mayer, Muguet-Chanoit, Okada, Okada, Olby, Olby, Pais, Penning, Platt, Priester, Sato, Scott, Shinzato, Smolders, Zachary   +34 more
core   +1 more source

Ultrasound‐Triggered Gelation for Restoring Biomechanical Properties of Degenerated Functional Spinal Units

Advanced Healthcare Materials, EarlyView.
This study introduces an innovative approach to treating intervertebral disc degeneration using ultrasound‐triggered in situ hydrogel formation. Proof‐of‐concept experiments using optimized biomaterial and ultrasound parameters demonstrate partial restoration of biomechanical function and successful integration into degenerated disc tissue, offering a ...
Veerle A. Brans, Anna P. Constantinou, Matthew J. Kibble, Valeria Nele, Daniel Reumann, Luca Bau, Sebastien J. P. Callens, James P. K. Armstrong, Nicolas Newell, Constantin C. Coussios, Molly M. Stevens, Michael D. Gray   +11 more
wiley   +1 more source

Role of Necroptosis in Intervertebral Disc Degeneration

International Journal of Molecular Sciences, 2023
Apoptosis has historically been considered the primary form of programmed cell death (PCD) and is responsible for regulating cellular processes during development, homeostasis, and disease. Conversely, necrosis was considered uncontrolled and unregulated.
Md Abdul Khaleque, Jae-Hoon Kim, Byung-Jun Hwang, Jin-Kyu Kang, Meiling Quan, Young-Yul Kim   +5 more
openaire   +2 more sources

Inflammatory biomarkers in sera of patients with intervertebral disc degeneration

Einstein (São Paulo)
Objective: To evaluate intervertebral disc levels of inflammatory factor (interleukin 6) and proteinase activity (cathepsin B) in patients with a degenerative disease and serum levels of interleukin 6, serum cathepsin B activity and hyaluronic acid ...
Luciano Miller Reis Rodrigues, Lilian Zerbinatti de Oliveira, Mariane de Barros Ribeiro da Silva, Camila de Melo Accardo, Adriana Braz Del Giglio, Maria Aparecida da Silva Pinhal   +5 more
doaj   +1 more source

Clarifying the nomenclature of intervertebral disc degeneration and displacement: from bench to bedside [PDF]

, 2014
As a significant determinant of low back pain, intervertebral disc degeneration (IDD) has attracted more and more attention of both investigators and physicians.
Samartzis, D, Wang, HQ
core