Results 1 to 10 of about 203,372 (288)

Simultaneous Prediction Method for Intestinal Absorption and Metabolism Using the Mini-Ussing Chamber System [PDF]

Pharmaceutics, 2023
Many evaluation tools for predicting human absorption are well-known for using cultured cell lines such as Caco-2, MDCK, and so on. Since the combinatorial chemistry and high throughput screening system, pharmacological assay, and pharmaceutical ...
Satoshi Kondo, Masateru Miyake
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Fatty acid transport protein 4 is dispensable for intestinal lipid absorption in mice*[S] [PDF]

Journal of Lipid Research, 2009
FA transport protein 4 (FATP4), one member of a multigene family of FA transporters, was proposed as a major FA transporter in intestinal lipid absorption.
Jien Shim, Casey L. Moulson, Elizabeth P. Newberry, Meei-Hua Lin, Yan Xie, Susan M. Kennedy, Jeffrey H. Miner, Nicholas O. Davidson   +7 more
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Progress in Research and Application of Intestinal Absorption Cell Models on Carotenoids [PDF]

Shipin Kexue, 2023
Dietary compounds are crucial in maintaining human physiological functions and preventing diseases, but they can give full play to their functional activities only after being effectively absorbed and utilized by the human body.
WU Fan, CHEN Nan, WU Yuqing, NI Yuanying, WEN Xin
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Quantifying the transport of biologics across intestinal barrier models in real-time by fluorescent imaging

Frontiers in Bioengineering and Biotechnology, 2022
Unsuccessful clinical translation of orally delivered biological drugs remains a challenge in pharmaceutical development and has been linked to insufficient mechanistic understanding of intestinal drug transport.
Arjen Weller, Arjen Weller, Morten B. Hansen, Morten B. Hansen, Rodolphe Marie, Rodolphe Marie, Adam C. Hundahl, Adam C. Hundahl, Casper Hempel, Casper Hempel, Paul J. Kempen, Paul J. Kempen, Henrik L. Frandsen, Ladan Parhamifar, Ladan Parhamifar, Jannik B. Larsen, Jannik B. Larsen, Thomas L. Andresen, Thomas L. Andresen   +18 more
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Injectable Hydrogels for Improving Cardiac Cell Therapy—In Vivo Evidence and Translational Challenges

Gels, 2021
Cell therapy has the potential to regenerate cardiac tissue and treat a variety of cardiac diseases which are currently without effective treatment. This novel approach to treatment has demonstrated clinical efficiency, despite low retention of the cell ...
Cecilie Hoeeg, Alireza Dolatshahi-Pirouz, Bjarke Follin   +2 more
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Cell-Penetrating Peptide-Surface Modified Liposomes to Enhance the Intestinal Absorption of Enoxaparin [PDF]

Pharmaceutical Sciences, 2023
Background: Enoxaparin is low-molecular-weight heparin administered by subcutaneous/intravenous injection. The oral bioavailability of enoxaparin is restricted by its low absorption through the intestine.
Hessam Rostamian, Hadi Valizadeh, Mohammad Mahmoudian, Ziba Islambulchilar, Parvin Zakeri-Milani   +4 more
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Mitochondrial reactive oxygen species modify extracellular vesicles secretion rate

FASEB BioAdvances, 2023
Extracellular vesicle (EV) secretion rate is stimulated by hypoxia that causes increased reactive oxygen species (ROS) production by the mitochondrial electron transport chain (ETC) and hypoxia‐induced factor (HIF)‐1 signaling; however, their ...
Mikkel Ø. Nørgård, Philip M. Lund, Nazmie Kalisi, Thomas L. Andresen, Jannik B. Larsen, Stefan Vogel, Per Svenningsen   +6 more
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Strategies and Mechanism in Reversing Intestinal Drug Efflux in Oral Drug Delivery

Pharmaceutics, 2022
Efflux transporters distributed at the apical side of human intestinal epithelial cells actively transport drugs from the enterocytes to the intestinal lumen, which could lead to extremely poor absorption of drugs by oral administration.
Rong Lu, Yun Zhou, Jinqian Ma, Yuchen Wang, Xiaoqing Miao   +4 more
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Application Research Progress of Intestinal Organoids in Nutrient Absorption

Shipin gongye ke-ji, 2022
The intestinal tract is not only the main part of nutrient digestion and absorption, but also an important immune and endocrine organ. The digestion and absorption of nutrients in the intestine is a crucial factor to achieve their efficient utilization ...
Yaxuan PENG, Shenglin DUAN, Zongling YANG, Yifeng LIU, Haizhi LI, Cong PAN, Youqiang YU, Kai XIA   +7 more
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Intestinal absorption of fats

Journal of Lipid Research, 1964
Great progress in understanding the mechanisms of fat absorption by the mammalian intestine has been made in the past decade and a half. In contrast to the contentions of rival theorists of the century before this, it has been possible for many ...
John R. Senior
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