Results 11 to 20 of about 203,372 (288)

Glyceroniosomes for enhanced intestinal absorption of hydrochlorothiazide and lisinopril in their fixed dose combination [PDF]

Scientific Reports
The objective was to investigate the effect of co-administration of hydrochlorothiazide and lisinopril as fixed dose combination on their intestinal absorption. The scope was extended to enhance intestinal absorption of both drugs.
Aya R. Elbasuony, Abdelaziz E. Abdelaziz, Eman A. Mazyed, Gamal M. El Maghraby   +3 more
doaj   +2 more sources

Bilosomes and Niosomes for Enhanced Intestinal Absorption and In Vivo Efficacy of Cytarabine in Treatment of Acute Myeloid Leukemia [PDF]

Pharmaceuticals
Cytarabine (CTR) is a hydrophilic anticancer drug used to treat leukemia. It suffers from poor permeability and intestinal metabolism, diminishing its oral bioavailability.
Abdelrahman R. Said, Mona F. Arafa, Walaa A. El-Dakroury, Sultan Alshehri, Gamal M. El Maghraby   +4 more
doaj   +2 more sources

Effect of luteolin on ceftiofur intestinal absorption: the rational use of Caco-2 monolayer cell model and everted gut sac model [PDF]

Poultry Science
Background: The clinical utility of ceftiofur primarily stems from its broad-spectrum antibacterial properties. However, its limited oral bioavailability significantly constrains therapeutic effectiveness.
Ruxia Wang, Zhiruo Kang, Mingang Li, Zehui Zhang, Yuru Guo, Shengli Niu, Limei Han, Chunlian Tian, Mingchun Liu   +8 more
doaj   +2 more sources

Orally administered intelligent self-ablating nanoparticles: a new approach to improve drug cellular uptake and intestinal absorption [PDF]

Drug Deliv, 2022
Yanzi Liang, Ruihuan Ding, Huihui Wang, Lanze Liu, Jibiao He, Yuping Tao, Zhenyu Zhao, Jie Zhang, Aiping Wang, Kaoxiang Sun, Youxin Li, Yanan Shi   +11 more
openalex   +2 more sources

Intestinal lipid absorption

American Journal of Physiology-Endocrinology and Metabolism, 2009
Our knowledge of the uptake and transport of dietary fat and fat-soluble vitamins has advanced considerably. Researchers have identified several new mechanisms by which lipids are taken up by enterocytes and packaged as chylomicrons for export into the lymphatic system or clarified the actions of mechanisms previously known to participate in these ...
Jahangir, Iqbal, M Mahmood, Hussain
openaire   +3 more sources

Recent Advances in the Gastrointestinal Complex in Vitro Model for ADME Studies

Pharmaceutics, 2023
Intestinal absorption is a complex process involving the permeability of the epithelial barrier, efflux transporter activity, and intestinal metabolism.
Kazuyoshi Michiba, Kengo Watanabe, Tomoki Imaoka, Daisuke Nakai   +3 more
doaj   +1 more source

Self‐Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering?

Advanced Science, 2019
Given their durability and long‐term stability, self‐healable hydrogels have, in the past few years, emerged as promising replacements for the many brittle hydrogels currently being used in preclinical or clinical trials. To this end, the incompatibility
Sepehr Talebian, Mehdi Mehrali, Nayere Taebnia, Cristian Pablo Pennisi, Firoz Babu Kadumudi, Javad Foroughi, Masoud Hasany, Mehdi Nikkhah, Mohsen Akbari, Gorka Orive, Alireza Dolatshahi‐Pirouz   +10 more
doaj   +1 more source

Assessment of contribution of BCRP to intestinal absorption of various drugs using portal‐systemic blood concentration difference model in mice

Pharmacology Research & Perspectives, 2020
Prediction of the intestinal absorption of new chemical entities (NCEs) is still difficult, in part because drug efflux transporters, including breast cancer resistance protein (BCRP) and P‐glycoprotein (P‐gp), restrict their intestinal permeability.
Iichiro Kawahara, Satoyo Nishikawa, Akira Yamamoto, Yusuke Kono, Takuya Fujita   +4 more
doaj   +1 more source

Development of active jejunal glucose absorption in broiler chickens

Poultry Science, 2023
: Growth in chickens, especially meat-type chickens (broilers), is extremely rapid, but studies on the regulatory mechanism of intestinal glucose absorption with growth are few, contradictory, and unclear.
Mikako Shibata, Tatsuyuki Takahashi, Takaharu Kozakai, Junji Shindo, Yohei Kurose   +4 more
doaj   +1 more source

Application of the steady-state intestinal perfusion system in measuring intestinal fluid absorption and bicarbonate secretion in vivo

Frontiers in Physiology, 2023
Background: The steady-state intestinal perfusion system represents a tool used in measuring intestinal fluid absorption and bicarbonate secretion in vivo; however, detailed procedures and parameters were not elucidated fully.Aim: We focused on the ...
Wenjuan Fan, Qinghai Tan
doaj   +1 more source