Results 11 to 20 of about 2,378,273 (384)

A Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models [PDF]

Nutrients, 2020
Zinc absorption in the small intestine is one of the main mechanisms regulating the systemic homeostasis of this essential trace element. This review summarizes the key aspects of human zinc homeostasis and distribution.
M. Maares, H. Haase
semanticscholar   +3 more sources

Anthocyanin Absorption and Metabolism by Human Intestinal Caco-2 Cells—A Review [PDF]

International Journal of Molecular Sciences, 2015
Anthocyanins from different plant sources have been shown to possess health beneficial effects against a number of chronic diseases. To obtain any influence in a specific tissue or organ, these bioactive compounds must be bioavailable, i.e., effectively ...
Senem Kamiloglu, E. Çapanoğlu, C. Grootaert, J. Van Camp   +3 more
semanticscholar   +8 more sources

Quantifying the transport of biologics across intestinal barrier models in real-time by fluorescent imaging

Frontiers in Bioengineering and Biotechnology, 2022
Unsuccessful clinical translation of orally delivered biological drugs remains a challenge in pharmaceutical development and has been linked to insufficient mechanistic understanding of intestinal drug transport.
Arjen Weller, Arjen Weller, Morten B. Hansen, Morten B. Hansen, Rodolphe Marie, Rodolphe Marie, Adam C. Hundahl, Adam C. Hundahl, Casper Hempel, Casper Hempel, Paul J. Kempen, Paul J. Kempen, Henrik L. Frandsen, Ladan Parhamifar, Ladan Parhamifar, Jannik B. Larsen, Jannik B. Larsen, Thomas L. Andresen, Thomas L. Andresen   +18 more
doaj   +1 more source

Injectable Hydrogels for Improving Cardiac Cell Therapy—In Vivo Evidence and Translational Challenges

Gels, 2021
Cell therapy has the potential to regenerate cardiac tissue and treat a variety of cardiac diseases which are currently without effective treatment. This novel approach to treatment has demonstrated clinical efficiency, despite low retention of the cell ...
Cecilie Hoeeg, Alireza Dolatshahi-Pirouz, Bjarke Follin   +2 more
doaj   +1 more source

Cell-Penetrating Peptide-Surface Modified Liposomes to Enhance the Intestinal Absorption of Enoxaparin [PDF]

Pharmaceutical Sciences, 2023
Background: Enoxaparin is low-molecular-weight heparin administered by subcutaneous/intravenous injection. The oral bioavailability of enoxaparin is restricted by its low absorption through the intestine.
Hessam Rostamian, Hadi Valizadeh, Mohammad Mahmoudian, Ziba Islambulchilar, Parvin Zakeri-Milani   +4 more
doaj   +1 more source

Vitamin D-Mediated Regulation of Intestinal Calcium Absorption

Nutrients, 2022
Vitamin D is a critical regulator of calcium and bone homeostasis. While vitamin D has multiple effects on bone and calcium metabolism, the regulation of intestinal calcium (Ca) absorption efficiency is a critical function for vitamin D.
J. Fleet
semanticscholar   +1 more source

Mitochondrial reactive oxygen species modify extracellular vesicles secretion rate

FASEB BioAdvances, 2023
Extracellular vesicle (EV) secretion rate is stimulated by hypoxia that causes increased reactive oxygen species (ROS) production by the mitochondrial electron transport chain (ETC) and hypoxia‐induced factor (HIF)‐1 signaling; however, their ...
Mikkel Ø. Nørgård, Philip M. Lund, Nazmie Kalisi, Thomas L. Andresen, Jannik B. Larsen, Stefan Vogel, Per Svenningsen   +6 more
doaj   +1 more source

Strategies and Mechanism in Reversing Intestinal Drug Efflux in Oral Drug Delivery

Pharmaceutics, 2022
Efflux transporters distributed at the apical side of human intestinal epithelial cells actively transport drugs from the enterocytes to the intestinal lumen, which could lead to extremely poor absorption of drugs by oral administration.
Rong Lu, Yun Zhou, Jinqian Ma, Yuchen Wang, Xiaoqing Miao   +4 more
doaj   +1 more source

Application Research Progress of Intestinal Organoids in Nutrient Absorption

Shipin gongye ke-ji, 2022
The intestinal tract is not only the main part of nutrient digestion and absorption, but also an important immune and endocrine organ. The digestion and absorption of nutrients in the intestine is a crucial factor to achieve their efficient utilization ...
Yaxuan PENG, Shenglin DUAN, Zongling YANG, Yifeng LIU, Haizhi LI, Cong PAN, Youqiang YU, Kai XIA   +7 more
doaj   +1 more source

Synergistic Mechanisms of Constituents in Herbal Extracts during Intestinal Absorption: Focus on Natural Occurring Nanoparticles

Pharmaceutics, 2020
The systematic separation strategy has long and widely been applied in the research and development of herbal medicines. However, the pharmacological effects of many bioactive constituents are much weaker than those of the corresponding herbal extracts ...
Qing Zhao, Xin Luan, Min Zheng, Xin-Hui Tian, Jing Zhao, Wei-Dong Zhang, Bing-Liang Ma   +6 more
semanticscholar   +1 more source