Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα
Nature Communications, 2021 Intestinal surface changes in size and function, but what propels these alterations and what are their metabolic consequences is unknown. Here we report that the food amount is a positive determinant of the gut surface area contributing to an increased ...
O. Stojanović +10 more
semanticscholar +1 more source
Low zinc status and absorption exist in infants with jejunostomies or ileostomies which persists after intestinal repair. [PDF]
, 2012 There is very little data regarding trace mineral nutrition in infants with small intestinal ostomies. Here we evaluated 14 infants with jejunal or ileal ostomies to measure their zinc absorption and retention and biochemical zinc and copper status. Zinc
Abrams, Steven A +5 more
core +4 more sources
Recent Advances in the Gastrointestinal Complex in Vitro Model for ADME Studies
Pharmaceutics, 2023 Intestinal absorption is a complex process involving the permeability of the epithelial barrier, efflux transporter activity, and intestinal metabolism.
Kazuyoshi Michiba +3 more
doaj +1 more source
Mechanisms of Carotenoid Intestinal Absorption: Where Do We Stand?
Nutrients, 2019 A growing literature is dedicated to the understanding of carotenoid beneficial health effects. However, the absorption process of this broad family of molecules is still poorly understood.
E. Reboul
semanticscholar +1 more source
Iron metabolism of intestinal mucosa in various blood diseases [PDF]
, 1964 For the investigation of iron metabolism in the intestinal mucosa in various blood diseases, intestinal biopsy (duodenum) was performed on 10 healthy controls and 35 cases with various blood diseases.
Kimura, Ikuro +2 more
core +1 more source
Intestinal Absorption of Bile Acids in Health and Disease.
Comprehensive Physiology, 2019 The intestinal reclamation of bile acids is crucial for the maintenance of their enterohepatic circulation. The majority of bile acids are actively absorbed via specific transport proteins that are highly expressed in the distal ileum. The uptake of bile
A. Ticho +4 more
semanticscholar +1 more source
Self‐Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering?
Advanced Science, 2019 Given their durability and long‐term stability, self‐healable hydrogels have, in the past few years, emerged as promising replacements for the many brittle hydrogels currently being used in preclinical or clinical trials. To this end, the incompatibility
Sepehr Talebian +10 more
doaj +1 more source
Pharmacology Research & Perspectives, 2020 Prediction of the intestinal absorption of new chemical entities (NCEs) is still difficult, in part because drug efflux transporters, including breast cancer resistance protein (BCRP) and P‐glycoprotein (P‐gp), restrict their intestinal permeability.
Iichiro Kawahara +4 more
doaj +1 more source
Development of active jejunal glucose absorption in broiler chickens
Poultry Science, 2023 : Growth in chickens, especially meat-type chickens (broilers), is extremely rapid, but studies on the regulatory mechanism of intestinal glucose absorption with growth are few, contradictory, and unclear.
Mikako Shibata +4 more
doaj +1 more source
Decision trees to characterise the roles of permeability and solubility on the prediction of oral absorption [PDF]
, 2015 Oral absorption of compounds depends on many physiological, physiochemical and formulation factors. Two important properties that govern oral absorption are in vitro permeability and solubility, which are commonly used as indicators of human intestinal ...
Alex A. Freitas +83 more
core +2 more sources