Results 81 to 90 of about 211,499 (300)

Effects of Acetaldehyde on Intestinal Barrier Function

, 2016
Ethanol-induced epithelial barrier dysfunction increases the risk of inflammatory and carcinogenic diseases. Acetaldehyde, being a key metabolite of ethanol metabolism, is highly mutagenic and cytotoxic, but also has a strong potency to affect the apical
Elhaseen E. Elamin, Daisy M. Jonkers, Masclee, Ad A., Jonkers, Daisy M., Ad A. Masclee, Elamin, Elhaseen E.   +5 more
core   +1 more source

Intestinal permeability measurements: general aspects and possible pitfalls

Nutrición Hospitalaria, 2014
Introduction: Disturbances of the gut barrier function have been related to a variety of diseases, including intestinal and extra-intestinal diseases. The intestinal permeability tests are considered useful tools for evaluating disease severity and to ...
Tatiana Fiche Salles Teixeira, Ana Paula Boroni Moreira, Nilian Carla Silva Souza, Rafael Frias, Maria do Carmo Gouveia Peluzio   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Commensal and probiotic bacteria influence intestinal barrier function and susceptibility to colitis in Nod1-/-; Nod2-/- mice

, 2012
The intestinal microbiota regulates key host functions. It is unknown whether modulation of the microbiota can affect a genetically determined host phenotype.
Clara L. Garcia Rodenas, Xianxi Huang, de Palma, Giada, Natividad, Jane M M, Elena F. Verdu, Jury, Jennifer, Garcia Rodenas, Clara L, Yolanda Sanz, Jane M.M. Natividad, Petit, Valerie, Valerie Petit, Kathy D. McCoy, Huang, Xianxi, Verdu, Elena F, Giada de Palma, Dana Philpott, Jennifer Jury, Philpott, Dana, McCoy, Kathy D, Sanz, Yolanda   +19 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Probiotic bacteria Bifidobacterium bifidum upregulation of intestinal epithelial tight junction barrier is mediated by TLR-2/TLR-6 receptor complex activation of occludin gene

npj Biofilms and Microbiomes
Defective intestinal epithelial tight junction (TJ) barrier is a key pathogenic factor of inflammatory bowel disease (IBD). Probiotic bacterial upregulation of intestinal TJ barrier has been shown to prevent the development of intestinal inflammation ...
Raz Abdulqadir, Rana Al-Sadi, Yash Gupta, Manmeet Rawat, Thomas Ma   +4 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Obstructive sleep apnea is related to alterations in fecal microbiome and impaired intestinal barrier function

, 2023
Obstructive Sleep Apnea (OSA) is related to repeated upper airway collapse, intermittent hypoxia, and intestinal barrier dysfunction. The resulting damage to the intestinal barrier may affect or be affected by the intestinal microbiota.
Danqing Li, Taoping Li, Xiumin Wang, Lijie Feng, Mingming Wang, Yin Jiang, Chuan Shao, Qianjun Li, Wenhui Gao, Fengbo Cai, Ting Xu, Qinge Xie, Yongquan Dong, Feijie Lu, Huanyu Tan   +14 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source