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Colorectal cancer (CRC) is the second most lethal malignancy around the world. Limited efficacy of immunotherapy creates an urgent need for development of novel treatment targets.
Hao Wang +17 more
doaj +1 more source
The Intestinal Microbiota in Metabolic Disease [PDF]
Gut bacteria exert beneficial and harmful effects in metabolic diseases as deduced from the comparison of germfree and conventional mice and from fecal transplantation studies. Compositional microbial changes in diseased subjects have been linked to adiposity, type 2 diabetes and dyslipidemia. Promotion of an increased expression of intestinal nutrient
Woting, Anni (Dr.) +1 more
openaire +3 more sources
Iron metabolism of intestinal mucosa in various blood diseases [PDF]
For the investigation of iron metabolism in the intestinal mucosa in various blood diseases, intestinal biopsy (duodenum) was performed on 10 healthy controls and 35 cases with various blood diseases.
Kimura, Ikuro +2 more
core +1 more source
MiR-21-3p Promotes Hepatocellular Carcinoma Progression via SMAD7/YAP1 Regulation
BackgroundHepatocellular carcinoma (HCC) remains a major global health burden due to its high prevalence and mortality. Emerging evidence reveals that microRNA (miRNA) plays a vital role in cancer pathogenesis and is widely involved in the regulation of ...
Yinghui Hong +21 more
doaj +1 more source
Intestinal microbiota in healthy adults: temporal analysis reveals individual and common core and relation to intestinal symptoms [PDF]
BACKGROUND: While our knowledge of the intestinal microbiota during disease is accumulating, basic information of the microbiota in healthy subjects is still scarce.
Vos, W.M., de +26 more
core +1 more source
The Gut-Brain Axis in IBD: An Investigator’s Perspective
Three clinical observations in inflammatory bowel disease (IBD) prompt an examination of the role of gut-brain interactions in the pathophysiology of IBD.
Stephen M Collins +2 more
doaj +1 more source
Gut Metagenome as a Potential Diagnostic and Predictive Biomarker in Slow Transit Constipation
Slow transit constipation (STC) is one of the most frequent gastrointestinal diagnoses. In this study, we conducted a quantitative metagenomics study in 118 Chinese individuals.
Hongliang Tian +23 more
doaj +1 more source
Intestinal Permeability Regulation by Tight Junction: Implication on Inflammatory Bowel Diseases [PDF]
Epithelial tight junctions (TJs) are the key structures regulating paracellular trafficking of macromolecules. The TJ is multi-protein complex that forms a selective permeable seal between adjacent epithelial cells and demarcates the boundary between ...
Sung Hee Lee
core +1 more source
Background & aimsThe global incidence of inflammatory bowel disease (IBD) has markedly increased over past several decades. Gender-specific differences have been observed in the epidemiology, manifestation, and prognosis of IBD.
Jingyi Peng +9 more
doaj +1 more source
Second Korean guidelines for the management of ulcerative colitis [PDF]
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by a relapsing and remitting course. The direct and indirect costs of the treatment of UC are high, and the quality of life of patients is reduced, especially during ...
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core +1 more source

