Results 11 to 20 of about 437,417 (289)

Intestinal Epithelial Cells In Vitro [PDF]

Stem Cells and Development, 2010
Recent advances in the biology of stem cells has resulted in significant interest in the development of normal epithelial cell lines from the intestinal mucosa, both to exploit the therapeutic potential of stem cells in tissue regeneration and to develop treatment models of degenerative disorders of the digestive tract.
Dharam P, Chopra, Alan A, Dombkowski, Paul M, Stemmer, Graham C, Parker   +3 more
openaire   +2 more sources

Insulin and intestinal epithelial cell proliferation [PDF]

Experimental Physiology, 1993
The effects of modification of the levels of endogenous plasma insulin on intestinal epithelial cell proliferation were investigated in rats maintained by total parenteral nutrition (TPN) using either a TPN diet that was high in glucose, or a low glucose (hypocaloric) TPN diet and in orally fed rats (normal and sham operated).
R A, Goodlad, C Y, Lee, S G, Gilbey, M A, Ghatei, S R, Bloom   +4 more
openaire   +2 more sources

Activation of intestinal epithelial Stat3 orchestrates tissue defense during gastrointestinal infection. [PDF]

PLoS ONE, 2015
Gastrointestinal infections with EHEC and EPEC are responsible for outbreaks of diarrheal diseases and represent a global health problem. Innate first-line-defense mechanisms such as production of mucus and antimicrobial peptides by intestinal epithelial
Nadine Wittkopf, Geethanjali Pickert, Ulrike Billmeier, Mousumi Mahapatro, Stefan Wirtz, Eva Martini, Moritz Leppkes, Markus Friedrich Neurath, Christoph Becker   +8 more
doaj   +1 more source

Cholera Toxin Suppresses Expression of Ubiquitin Editing Enzyme A20 and Enhances Transcytosis

Cellular Physiology and Biochemistry, 2013
Background: The ubiquitin editing enzyme A20 plays an important role in maintaining the homeostasis in the body Microbe-derived adjuvants are commonly used in animal models of intestinal allergy.
Ming-Yang Li, Min Zhu, Bing Zhu, Zhi-Qiang Wang   +3 more
doaj   +1 more source

Modeling gut neuro-epithelial connections in a novel microfluidic device

Microsystems & Nanoengineering, 2023
The intestinal lumen is filled with diverse chemical and physical stimuli. Intestinal epithelial cells sense these stimuli and signal to enteric neurons which coordinate a range of physiologic processes required for normal digestive tract function.
Jose M. de Hoyos-Vega, Xi Yu, Alan M. Gonzalez-Suarez, Sisi Chen, Arnaldo Mercado-Perez, Eugene Krueger, Jeric Hernandez, Yaroslav Fedyshyn, Brooke R. Druliner, David R. Linden, Arthur Beyder, Alexander Revzin   +11 more
doaj   +1 more source

Cryptosporidial Infection Suppresses Intestinal Epithelial Cell MAPK Signaling Impairing Host Anti-Parasitic Defense

Microorganisms, 2021
Cryptosporidium is a genus of protozoan parasites that infect the gastrointestinal epithelium of a variety of vertebrate hosts. Intestinal epithelial cells are the first line of defense and play a critical role in orchestrating host immunity against ...
Wei He, Juan Li, Ai-Yu Gong, Silu Deng, Min Li, Yang Wang, Nicholas W. Mathy, Yaoyu Feng, Lihua Xiao, Xian-Ming Chen   +9 more
doaj   +1 more source

Epithelial cell shedding and barrier function: a matter of life and death at the small intestinal villus tip [PDF]

, 2015
The intestinal epithelium is a critical component of the gut barrier. Composed of a single layer of intestinal epithelial cells (IECs) held together by tight junctions, this delicate structure prevents the transfer of harmful microorganisms, antigens ...
A. J. M. Watson, B. J. Campbell, Beaulieu JF, Brown CC, C. A. Duckworth, Casellas F, D. M. Pritchard, Gelberg HB, J. M. Williams, Kaur P, Lee JS, Lobo SM, M. D. Burkitt, Mayhew TM, Moore R, Peschon JJ   +15 more
core   +4 more sources

Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation [PDF]

, 2016
Although defects in intestinal barrier function are discussed as a key pathogenic factor in patients with inflammatory bowel diseases (IBD), the molecular pathways driving disease-specific alterations of intestinal epithelial cells (IECs) are largely ...
Alastair J.M. Watson, Arif B. Ekici, Becker, Christoph Becker, Claudia Günther, Cord Brakebusch, Distler, Gionata Fiorino, Heller, Hopkins, Imke Atreya, Kerstin Amann, Lin, Markus F. Neurath, Martin Bergö, Ohkusa, Pastorelli, Pechlivanis, Raja Atreya, Rocío López-Posadas, Silvio Danese, Stefan Tenzer, Stefan Wirtz, Stefania Vetrano, Turcotte, Ulrike Billmeier, Veronika Thonn, Zverina   +27 more
core   +1 more source

Epigenetics in Intestinal Epithelial Cell Renewal [PDF]

Journal of Cellular Physiology, 2016
A controlled balance between cell proliferation and differentiation is essential to maintain normal intestinal tissue renewal and physiology. Such regulation is powered by several intracellular pathways that are translated into the establishment of specific transcription programs, which influence intestinal cell fate along the crypt-villus axis.
Roostaee, Alireza, Benoit, Yannick D., Boudjadi, Salah, Beaulieu, Jean‐François   +3 more
openaire   +2 more sources

Laminaria japonica Extract Enhances Intestinal Barrier Function by Altering Inflammatory Response and Tight Junction-Related Protein in Lipopolysaccharide-Stimulated Caco-2 Cells. [PDF]

, 2019
In the normal physiological state, intestinal epithelial cells act as a defensive frontline of host mucosal immunity to tolerate constant exposure to external stimuli.
Ding, Eom, Fawaz G Haj, Folin, Guiguo Zhang, Heo, Hyo-Seon Yang, Inhae Kang, Myoungsook Lee, Shirosaki, Shon, Wells, Wolfrom, Yunkyoung Lee   +13 more
core   +1 more source