Primary Cilium Identifies a Quiescent Cell Population in the Human Intestinal Crypt
Cells, 2023 Primary cilia are sensory antennae located at the cell surface which mediate a variety of extracellular signals involved in development, tissue homeostasis, stem cells and cancer.
Blanche Sénicourt +6 more
doaj +1 more source
LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. [PDF]
, 2018 Epithelial dysfunction and crypt destruction are defining features of inflammatory bowel disease (IBD). However, current IBD therapies targeting epithelial dysfunction are lacking.
Bayrer, James R +8 more
core +2 more sources
Consuming transgenic goats' milk containing the antimicrobial protein lysozyme helps resolve diarrhea in young pigs. [PDF]
, 2013 Childhood diarrhea is a significant problem in many developing countries and E. coli is a main causative agent of diarrhea in young children. Lysozyme is an antimicrobial protein highly expressed in human milk, but not ruminant milk, and is thought to ...
Cooper, Caitlin A +3 more
core +9 more sources
Optimization, Characteristics, and Functions of Alkaline Phosphatase From Escherichia coli
Frontiers in Microbiology, 2022 Weaning of piglets could increase the risk of infecting with Gram-negative pathogens, which can further bring about a wide array of virulence factors including the endotoxin lipopolysaccharide (LPS).
Yachao Dong +19 more
doaj +1 more source
Anthocyanin absorption and metabolism by human intestinal Caco-2 cells: a review [PDF]
, 2015 Anthocyanins from different plant sources have been shown to possess health beneficial effects against a number of chronic diseases. To obtain any influence in a specific tissue or organ, these bioactive compounds must be bioavailable, i.e., effectively ...
Battino, Maurizioeditor +4 more
core +3 more sources
The Role of Lactoferrin in Intestinal Health
Pharmaceutics, 2023 The intestine represents one of the first barriers where microorganisms and environmental antigens come into tight contact with the host immune system. A healthy intestine is essential for the well-being of humans and animals. The period after birth is a very important phase of development, as the infant moves from a protected environment in the uterus
Celia Conesa +3 more
openaire +5 more sources
In-feed resin acids reduce matrix metalloproteinase activity in the ileal mucosa of healthy broilers without inducing major effects on the gut microbiota [PDF]
, 2019 The chicken gut is constantly exposed to harmful molecules and microorganisms which endanger the integrity of the intestinal wall. Strengthening intestinal mucosal integrity is a key target for feed additives that aim to promote intestinal health in ...
Aguirre Morales, Marisol +8 more
core +8 more sources
Frontiers in Bioengineering and Biotechnology, 2022 Unsuccessful clinical translation of orally delivered biological drugs remains a challenge in pharmaceutical development and has been linked to insufficient mechanistic understanding of intestinal drug transport.
Arjen Weller +18 more
doaj +1 more source
The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression [PDF]
, 2009 The gastrointestinal tract represents the first barrier against food contaminants as well as the first target for these toxicants. Deoxynivalenol (DON) is a mycotoxin that commonly contaminates cereals and causes various toxicological effects.
Bracarense, Ana-Paula +8 more
core +2 more sources
Journal of Applied Animal Research, 2023 This study explored the effects of different protein and energy levels on growth performance and serum biochemical indices of ewes during early and mid-pregnancy.
Xin Wang +10 more
doaj +1 more source