Results 61 to 70 of about 515,539 (267)

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Exploring the genomic traits of infant-associated microbiota members from a Zimbabwean cohort

BMC Genomics
Introduction Our understanding of particular gut microbiota members such as Bifidobacterium and Enterococcus in low-middle-income countries remains very limited, particularly early life strain-level beneficial traits.
Taona Emmah Mudhluli, Magdalena Kujawska, Julia Mueller, Angela Felsl, Bastian-Alexander Truppel, Lindsay J. Hall, Inam Chitsike, Exnevia Gomo, Danai Tavonga Zhou   +8 more
doaj   +1 more source

Dual Role of Indoles Derived From Intestinal Microbiota on Human Health [PDF]

, 2022
Xuewei Ye, Haiyi Li, Komal Anjum, Xinye Zhong, Shuping Miao, Guowan Zheng, Wei Liu, Lanjuan Li   +7 more
openalex   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Reconsideration of the laminin receptor 67LR in colorectal cancer cells

Biomolecules & Biomedicine
The 67 kDa laminin receptor (67LR) was identified as the first laminin receptor shown to be involved in the carcinogenesis of various cancers, including colorectal cancer.
Gabriel Cloutier, Jean-François Beaulieu   +1 more
doaj   +1 more source

Neoexpression of a functional primary cilium in colorectal cancer cells

Heliyon, 2016
The Hedgehog (HH) signaling pathway is involved in the maintenance of numerous cell types both during development and in the adult. Often deregulated in cancers, its involvement in colorectal cancer has come into view during the last few years, although ...
Blanche Sénicourt, Salah Boudjadi, Julie C Carrier, Jean-François Beaulieu   +3 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Intravenous Iron Infusion in the Treatment of Iron Deficiency Anaemia Following Bariatric and Metabolic Surgery and Correlation with Gynaecological Disorders: Retrospective Review of Experience from a Tertiary Centre

Medicina
Background and Objectives: Iron deficiency anaemia (IDA) is a common consequence of bariatric and metabolic surgery (BMS). Women are at higher risk, and some patients cannot tolerate oral iron. This study aimed to report the demographics of patients with
Emma MacVicar, Nivar Saleh, Joy Tneoh, James Lucocq, Georgios Geropoulos, Beverley Wallace, Anne Ewing, Peter J. Lamb, Gillian Drummond, Brian Joyce, Andrew G. Robertson   +10 more
doaj   +1 more source

Effects of dietary supplementation with purple garlic powder and oregano essential oil on intestinal health in post-weaning piglets from commercial farms [PDF]

, 2022
Daniel Serrano-Jara, Jorge Rivera-Gomis, José Antonio Tornel, A. Bernabé, Cristina Martínez Conesa, J. A. Navarro, Ricardo Cánovas, Julio Otal, María José Cubero Pablo   +8 more
openalex   +1 more source