Results 61 to 70 of about 993,806 (361)

The therapeutic management of gut barrier leaking: the emerging role for mucosal barrier protectors [PDF]

, 2015
OBJECTIVE: Gut barrier is a functional unit organized as a multi-layer system and its multiple functions are crucial for maintaining gut homeostasis. Numerous scientific evidences showed a significant association between gut barrier leaking and gastro ...
Bruno, G, Franceschi, F, Gasbarrini, A, Lopetuso, Lr, Petito, V, Scaldaferri, F   +5 more
core  

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Isolation and Mechanistic Investigation of the Efficient Zearalenone-Removing Strain Bacillus licheniformis YJ25

Toxins
Zearalenone (ZEN), a non-steroidal estrogenic mycotoxin produced by Fusarium graminearum species, poses a significant threat to both human food safety and animal feed quality. In this study, we isolated a strain, designated as Bacillus licheniformis YJ25,
Yuting Wu, Feina Wu, Pan Zhao, Yan Gao, Mengyao Li, Mengjiao Luo, Qian Zhou, Siyuan Zhou, Xinhui Li, Yaling Hong, Yang Wu, Zhaorong Zhou, Yang Liu, Yandong Xia, Lijun Zou, Jia Yin   +15 more
doaj   +1 more source

Bioactivation of Phytoestrogens: Intestinal Bacteria and Health

Critical Reviews in Food Science and Nutrition, 2015
Phytoestrogens are polyphenols similar to human estrogens found in plants or derived from plant precursors. Phytoestrogens are found in high concentration in soya, flaxseed and other seeds, fruits, vegetables, cereals, tea, chocolate, etc. They comprise several classes of chemical compounds (stilbenes, coumestans, isoflavones, ellagitannins, and ...
Landete, José María, Arques Orobón, Juan Luis, Medina, Margarita, Gaya Sicilia, María Pilar, De Las Rivas, Blanca, Muñoz, Rosario   +5 more
openaire   +4 more sources

Intestinal SGLT1 in metabolic health and disease [PDF]

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2016
The Na+-glucose cotransporter 1 (SGLT1/SLC5A1) is predominantly expressed in the small intestine. It transports glucose and galactose across the apical membrane in a process driven by a Na+ gradient created by Na+-K+-ATPase. SGLT2 is the major form found in the kidney, and SGLT2-selective inhibitors are a new class of treatment for type 2 diabetes ...
Anders, Lehmann, Pamela J, Hornby
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway

Frontiers in Cell and Developmental Biology
Background:The COBLL1 gene has been implicated in human central obesity, fasting insulin levels, type 2 diabetes, and blood lipid profiles. However, its molecular mechanisms remain largely unexplored.Methods:In this study, we established cobll1a mutant ...
Ting Zeng, Ting Zeng, Jinrui Lv, Jinrui Lv, Jiaxin Liang, Jiaxin Liang, Binling Xie, Binling Xie, Ling Liu, Ling Liu, Yuanyuan Tan, Yuanyuan Tan, Junwei Zhu, Junwei Zhu, Jifan Jiang, Jifan Jiang, Huaping Xie, Huaping Xie   +17 more
doaj   +1 more source

Effects of dietary energy on growth performance, carcass characteristics, serum biochemical index, and meat quality of female Hu lambs

Animal Nutrition, 2020
This study evaluated the effects of dietary energy levels on growth performance, carcass traits, meat quality, and serum biochemical of female Hu lambs. Seventy female Hu lambs (aged 4 months) were randomly allotted to 5 dietary treatments.
Yancan Wang, Qiye Wang, Chunpeng Dai, Jianzhong Li, Pengfei Huang, Yali Li, Xueqin Ding, Jing Huang, Tarique Hussain, Huansheng Yang   +9 more
doaj   +1 more source