Results 31 to 40 of about 190,131 (263)

Sirtuin 6 maintains epithelial STAT6 activity to support intestinal tuft cell development and type 2 immunity

Nature Communications, 2022
Host defense against helminth infection is mediated by mucosal type 2 immunity. Using gain- and loss-of-function mouse models, and mouse intestinal organoids, Xiong et al.
Xiwen Xiong, Chenyan Yang, Wei-Qi He, Jiahui Yu, Yue Xin, Xinge Zhang, Rong Huang, Honghui Ma, Shaofang Xu, Zun Li, Jie Ma, Lin Xu, Qunyi Wang, Kaiqun Ren, Xiaoli S. Wu, Christopher R. Vakoc, Jiateng Zhong, Genshen Zhong, Xiaofei Zhu, Yu Song, Hai-Bin Ruan, Qingzhi Wang   +21 more
doaj   +1 more source

Intestinal Colonization and Programming of the Intestinal Immune Response [PDF]

Journal of Clinical Gastroenterology, 2014
Initial bacterial colonization of the gut is a vital component of the development of the gastrointestinal tract, particularly mucosal immune protection, during the neonatal period. Newborn infants in their protected intrauterine environment are suddenly thrust into a highly contaminated extrauterine state.
openaire   +2 more sources

Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity

Frontiers in Nutrition, 2019
Vitamins are micronutrients that have physiological effects on various biological responses, including host immunity. Therefore, vitamin deficiency leads to increased risk of developing infectious, allergic, and inflammatory diseases.
Ken Yoshii, Ken Yoshii, Koji Hosomi, Kento Sawane, Kento Sawane, Kento Sawane, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa   +11 more
doaj   +1 more source

Tumor suppressor p53 regulates intestinal type 2 immunity

Nature Communications, 2021
P53 is a well-known tumour suppressor, however its role in intestinal type 2 immunity is currently unclear. Here authors report that during parasitic infections, p53 triggers tuft cell Ca2+ influx and IL-25 release, and shows a regulatory role for p53 in
Chun-Yuan Chang, Jianming Wang, Yuhan Zhao, Juan Liu, Xue Yang, Xuetian Yue, Huaying Wang, Fan Zhou, Juan M. Inclan-Rico, John J. Ponessa, Ping Xie, Lanjing Zhang, Mark C. Siracusa, Zhaohui Feng, Wenwei Hu   +14 more
doaj   +1 more source

Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity

Journal of Immunology Research, 2019
The mammalian intestine harbors a remarkable number of microbes and their components and metabolites, which are fundamental for the instigation and development of the host immune system. The intestinal innate and adaptive immunity coordinate and interact
Li Wang, Limeng Zhu, Song Qin
doaj   +1 more source

Classical Complement Pathway Inhibition in a Pediatric Patient With Refractory Immune Thrombocytopenia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh, Susmita Sarangi, Caileigh Pudela, Catherine M. Broome, Tara K. Suntum   +4 more
wiley   +1 more source

Acute peritonitis-induced adipose CD127+ ILC1s express PD-L1 and ameliorate inflammation in mice

Nature Communications
Peritonitis is an inflammation of the peritoneum primarily caused by gut perforation and consequent bacterial leakage, a known cause of sepsis. Although adipose tissue is recognized as an immunologically active organ, the involvement of adipose tissue ...
Ritsu Nagata, Yuichi Akama, Pedro Goncalves, Nicolas Serafini, Tomoko Kageyama, Masami Kawasumi, Manami Satoh, Motomu Shimaoka, Hiroshi Ohno, Naoko Satoh-Takayama   +9 more
doaj   +1 more source

Eosinophils in infection and intestinal immunity [PDF]

Current Opinion in Gastroenterology, 2013
Inflammatory bowel diseases (IBDs, e.g., Crohn's disease and ulcerative colitis) are thought to be a consequence of an uncontrolled inflammatory response against luminal antigens, including commensal bacteria. The observed link between eosinophil levels and severity and remission rates in IBD has led to speculation that eosinophils may contribute to ...
Simon P, Hogan, Amanda, Waddell, Patricia C, Fulkerson   +2 more
openaire   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Humanized avian embryo models replicate an immune tumor environment for rapid immunotherapy studies

EMBO Molecular Medicine
Re-arming the immune system to fight cancer holds significant promise. However, models enabling the rapid and reliable evaluation of immunotherapies on patient tumors are still lacking.
Marjorie Lacourrège, Loraine Jarrosson, Clélia Costechareyre, Mathis Marcel, Audrey Prunet, Mayrone Mongellaz, Camille Futelot, Cyrus Rouhani, Huong Giang Nguyen, Thomas Aparicio, Lionel Le Bourhis, Céline Delloye-Bourgeois, Romain Teinturier, Valérie Castellani   +13 more
doaj   +1 more source