Results 71 to 80 of about 330,676 (367)

Visualizing intestines for diagnostic assistance of ileus based on intestinal region segmentation from 3D CT images [PDF]

open access: yesSPIE Medical Imaging 2020, 11314-109, 2020
This paper presents a visualization method of intestine (the small and large intestines) regions and their stenosed parts caused by ileus from CT volumes. Since it is difficult for non-expert clinicians to find stenosed parts, the intestine and its stenosed parts should be visualized intuitively.
arxiv  

A Bioengineered Model of the Human Cornea for Preclinical Assessment of Human Ocular Exposure to Environmental Toxicants

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
This paper presents a microphysiological system containing an array of individually addressable living corneal tissues constructed using primary human cells. The bioengineered eye model can simulate acute exposure of the human cornea to different types of environmental toxicants and provides a novel platform for visualization and quantitative ...
Se‐jeong Kim   +12 more
wiley   +1 more source

Investigations into the absorption of insulin and insulin derivatives from the small intestine of the anaesthetised rat [PDF]

open access: yes, 2016
Experiments have been undertaken to determine the extent to which cholic acid conjugates of insulin were absorbed from the small intestine of anaesthetised rats by means of the bile salt transporters of the ileum.
McGinn, B.J., Morrison, J.D.
core   +1 more source

Effects of glycolysis and polyamine predation on intestinal epithelial barrier in colorectal cancer

open access: yesFrontiers in Oncology, 2022
Colorectal cancer (CRC) is the second most lethal cancer and the third most common cancer in the world, and its prognosis is severely affected by high intestinal mucosal permeability and increasing tumor burden.
Yu Wang   +6 more
doaj   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

open access: yesAdvanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray   +2 more
wiley   +1 more source

Intestinal epithelial replacement by transplantation of cultured murine and human cells into the small intestine. [PDF]

open access: yes, 2019
Adult intestinal epithelial stem cells are a promising resource for treatment of intestinal epithelial disorders that cause intestinal failure and for intestinal tissue engineering.
Cho, Yonghoon   +9 more
core   +1 more source

Tipping Elements in the Human Intestinal Ecosystem [PDF]

open access: yes, 2014
Recent studies show that the microbial communities inhabiting the human intestine can have profound impact on our well-being and health. However, we have limited understanding of the mechanisms that control this complex ecosystem. Based on a deep phylogenetic analysis of the intestinal microbiota in a thousand western adults we identified groups of ...
arxiv   +1 more source

Feedback patterns in simulating intestinal wall motions: interdisciplinary approach to the motility mechanisms [PDF]

open access: yesarXiv, 2021
Ability of smooth muscles to contract in response to distension plays a crucial role in motor function of intestine. Qualitative analysis of dynamical models using myogenic active property of smooth muscles has shown well agreement with physiologic data.
arxiv  

Biotransformation of xenobiotics in human intestinal mucosa [PDF]

open access: yesEnvironmental Health Perspectives, 1979
Drug-metabolizing enzymes, especially monooxygenases, play a major role in biotransformation and detoxification of many foreign compounds including environmental carcinogens. Although largely localized in the liver they are also found in the small intestine, which is the portal of entry of dietary toxins.
F. Hartmann, R. Hutt, H. P. Hoensch
openaire   +3 more sources

Glepaglutide‐Loaded Foam for the Induction of Mucosal Healing in the Treatment of Inflammatory Bowel Disease

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Glepaglutide (GL), a GLP‐2 analog with an extended half‐life (50 h), is currently undergoing clinical trials for patients with short bowel syndrome. GL requires subcutaneous injection, which poses challenges for potential patient compliance. To address this challenge, we loaded GL into a rectal foam formulation using CO2 as a permeation enhancer to ...
Wunan Zhang   +9 more
wiley   +1 more source

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