Results 91 to 100 of about 215,029 (331)

From the intestinal mucosal barrier to the enteric neuromuscular compartment: an integrated overview on the morphological changes in Parkinson’s disease

European Journal of Histochemistry, 2021
Gastrointestinal dysfunctions represent the most common non-motor symptoms in Parkinson’s disease (PD). Of note, changes in gut microbiota, impairments of intestinal epithelial barrier (IEB), bowel inflammation and neuroplastic rearrangements of the ...
Carolina Pellegrini, Vanessa D'Antongiovanni, Chiara Ippolito, Cristina Segnani, Luca Antonioli, Matteo Fornai, Nunzia Bernardini   +6 more
doaj   +1 more source

Intestinal Intraepithelial Lymphocytes: Sentinels of the Mucosal Barrier

Trends in Immunology, 2018
Intestinal intraepithelial lymphocytes (IELs) are a large and diverse population of lymphoid cells that reside between the intestinal epithelial cells (IECs) that form the intestinal mucosal barrier. Although IEL biology has traditionally focused on T cells, recent studies have identified several subsets of T cell receptor (TCR)-negative IELs with ...
Danyvid, Olivares-Villagómez, Luc, Van Kaer   +1 more
openaire   +3 more sources

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

The Microbiome Activates CD4 T-cell–mediated Immunity to Compensate for Increased Intestinal PermeabilitySummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
Background & Aims: Despite a prominent association, chronic intestinal barrier loss is insufficient to induce disease in human subjects or experimental animals.
Karen L. Edelblum, Gil Sharon, Gurminder Singh, Matthew A. Odenwald, Anne Sailer, Severine Cao, Sarina Ravens, Irene Thomsen, Kamal El Bissati, Rima McLeod, Chen Dong, Sandeep Gurbuxani, Immo Prinz, Sarkis K. Mazmanian, Jerrold R. Turner   +14 more
doaj   +1 more source

Mechanisms by Which Traditional Chinese Medicines Influence the Intestinal Flora and Intestinal Barrier

Frontiers in Cellular and Infection Microbiology, 2022
The effect of a drug on the intestinal flora and the intestinal barrier is an important evaluation index for drug safety and efficacy. Chemical synthetic drugs are widely used due to their advantages of fast efficacy and low doses, but they are prone to ...
Qingya Che, Tingting Luo, Junhua Shi, Yihuai He, De-Lin Xu   +4 more
doaj   +1 more source

Role of the protein annexin A1 on the efficacy of anti-TNF treatment in a murine model of acute colitis [PDF]

, 2016
TNF-α is involved in the mechanisms that initiate inflammatory bowel diseases (IBDs). Anti-TNF-α drugs, such as infliximab (IFX), cause non-responsiveness and side effects, indicating the need to investigate alternative therapies for these diseases.
Barrios, Bibiana Elisabet, Correa, Silvia Graciela, De Paula Silva, Marina, Maccio Maretto, Lisa, Oliani, Sonia María, Poliselli Farsky, Sandra Helena, Sena, Angela   +6 more
core   +1 more source

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

Berberine Reduces Uremia-Associated Intestinal Mucosal Barrier Damage

Biological & Pharmaceutical Bulletin, 2016
Berberine is one of the main active constituents of Rhizoma coptidis, a traditional Chinese medicine, and has long been used for the treatment of gastrointestinal disorders. The present study was designed to investigate the effects of berberine on the intestinal mucosal barrier damage in a rat uremia model induced by the 5/6 kidney resection. Beginning
Chao, Yu, Shanjun, Tan, Chunyu, Zhou, Cuilin, Zhu, Xin, Kang, Shuai, Liu, Shuang, Zhao, Shulin, Fan, Zhen, Yu, Ai, Peng, Zhen, Wang   +10 more
openaire   +3 more sources

The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression [PDF]

, 2009
The gastrointestinal tract represents the first barrier against food contaminants as well as the first target for these toxicants. Deoxynivalenol (DON) is a mycotoxin that commonly contaminates cereals and causes various toxicological effects.
Bracarense, Ana-Paula, Del Rio, Juan-Carlos, Ferrier, Laurent, Kolf-Clauw, Martine, Marin, Daniela E., Moreno, Carolina, Nougayrède, Jean-Philippe, Oswald, Isabelle P, Pinton, Philippe   +8 more
core   +2 more sources

Danggui Buxue Decoction Ameliorates Inflammatory Bowel Disease by Improving Inflammation and Rebuilding Intestinal Mucosal Barrier

Evidence-Based Complementary and Alternative Medicine, 2021
Objective This study aimed to determine whether Danggui Buxue decoction (DGBX) can improve inflammatory bowel disease (IBD) by regulating immunity and promoting intestinal mucosal repair.
Chengyin Li, F. Zhu, Shasha Wang, Jing Wang, Bin Wu   +4 more
semanticscholar   +1 more source