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Disruption of the Intestinal Mucosal Barrier Induced by High Fructose and Restraint Stress Is Regulated by the Intestinal Microbiota and Microbiota Metabolites

Microbiology Spectrum, 2023
A high-fructose diet aggravated restraint stress-induced changes in the composition of the intestinal microbiome, in which the abundance of A. muciniphila was significantly increased. The high-fructose diet exacerbated restraint stress-induced the changes in the composition of the microbial metabolites, with taurine
Ruiping She, Yaoxing Chen, Yulan Dong
exaly   +3 more sources

The alteration of intestinal mucosal α-synuclein expression and mucosal microbiota in Parkinson’s disease

Applied Microbiology and Biotechnology, 2023
Abstract Parkinson’s disease (PD) is the second most common neurodegenerative disease but still lacks a preclinical strategy to identify it. The diagnostic value of intestinal mucosal α-synuclein (αSyn) in PD has not drawn a uniform conclusion.
Luo Qingfeng, Jihua Shi
exaly   +3 more sources

Intestinal mucosal tolerance and impact of gut microbiota to mucosal tolerance [PDF]

Frontiers in Microbiology, 2015
The mucosal barriers are very sensitive to pathogenic infection, thereby assuming the capacity of the mucosal immune system to induce protective immunity to harmful antigens and tolerance against harmless substances. This review provides current information about mechanisms of induction of mucosal tolerance and about impact of gut microbiota to mucosal
Dimitry Chistiakov, Alexander Orekhov, Yuri V Bobryshev   +2 more
exaly   +5 more sources

Fecal Microbiota Transplantation Protects the Intestinal Mucosal Barrier by Reconstructing the Gut Microbiota in a Murine Model of Sepsis [PDF]

Frontiers in Cellular and Infection Microbiology, 2021
The gastrointestinal (GI) tract has long been hypothesized to play an integral role in the pathophysiology of sepsis, and gut microbiota (GM) dysbiosis may be the key factor. Previous studies have shown that the gut flora was significantly altered in critically ill patients. This study aimed to observe what kind of GM dysbiosis is in the early stage of
Haotian Zhao, Heling Zhao
exaly   +4 more sources

Crosstalk between the gut microbiota and innate lymphoid cells in intestinal mucosal immunity

Frontiers in Immunology, 2023
The human gastrointestinal mucosa is colonized by thousands of microorganisms, which participate in a variety of physiological functions. Intestinal dysbiosis is closely associated with the pathogenesis of several human diseases. Innate lymphoid cells (ILCs), which include NK cells, ILC1s, ILC2s, ILC3s and LTi cells, are a type of innate immune cells ...
Yuling Guo
exaly   +4 more sources

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Distinctions Between Fecal and Intestinal Mucosal Microbiota in Subgroups of Irritable Bowel Syndrome

Digestive Diseases and Sciences, 2022
Recent studies have shown that changes in the intestinal microbiota contribute to the pathogenesis of irritable bowel syndrome (IBS). This study aimed to investigate the characteristics of the fecal and intestinal mucosal microbiota in IBS patients, and the correlation between microbiota and clinical manifestations.Fecal and intestinal mucosal samples ...
Wang Shenhao
exaly   +3 more sources

Interactions of the Intestinal Microbiota with Mucosal Epithelial Cells

2014
International ...
Cherbuy, Claire, Tomas, Julie, Thomas, Muriel, Langella, Philippe   +3 more
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Dendrobium huoshanense polysaccharide regionally regulates intestinal mucosal barrier function and intestinal microbiota in mice

Carbohydrate Polymers, 2019
The present study investigated the effects of a homogeneous Dendrobium huoshanense polysaccharide (GXG) on mucosal barrier function and microbiota composition in different intestinal regions of mice. Results exhibited, besides changing the intestinal physiological status, orally administrated GXG could improve the intestinal physical barrier function ...
Jian-Ping Luo, Jun Duan, Xueqiang Zha
exaly   +3 more sources

Gut microbiota as a key regulator of intestinal mucosal immunity

Life Sciences
Gut microbiota is a complex microbial community with the ability of maintaining intestinal health. Intestinal homeostasis largely depends on the mucosal immune system to defense external pathogens and promote tissue repair. In recent years, growing evidence revealed the importance of gut microbiota in shaping intestinal mucosal immunity.
Jing, Wang, Mei, He, Ming, Yang, Xiaopeng, Ai   +3 more
exaly   +3 more sources