Results 41 to 50 of about 234,915 (329)

Decision trees to characterise the roles of permeability and solubility on the prediction of oral absorption [PDF]

, 2015
Oral absorption of compounds depends on many physiological, physiochemical and formulation factors. Two important properties that govern oral absorption are in vitro permeability and solubility, which are commonly used as indicators of human intestinal ...
Alex A. Freitas, Amidon, Artursson, Artursson, Avdeef, Bai, Balaban, Balimane, Bergstrom, Bergstrom, BNF, Boobis, Braun, Breiman, BriskeAnderson, Buckley, CDER/FDA, Chen, Cheng, Chu, Clark, Danielle Newby, Di, Dressman, Egan, Englund, Fagerholm, FDA, Fogh, Gao, Gasteiger, Gertz, Ghafourian, Gres, Hahn, Hayeshi, Hebert, Hidalgo, Hilgendorf, Hilgendorf, Hou, Irvine, Jacobsen, Jain, Le Ferrec, Lin, Lipinski, Lipinski, Matsson, Mehramizi, Merino, Miller, Minuesa, Newby, Newby, Niwa, Pade, Pham-The, Pham-The, Pinto, Quan, Sanghvi, Savjani, Shah, Shugarts, Stegemann, Stenberg, Sugano, Sugano, Taravat Ghafourian, Tavelin, The, Ungell, van Breemen, van de Waterbeemd, Varma, Varma, Varma, Volpe, Wang, Wessel, Yee, Zhao, Zhao   +83 more
core   +2 more sources

Increased intestinal permeability in primary Sjögren’s syndrome and multiple sclerosis

Journal of Translational Autoimmunity, 2021
There is increasing evidence suggesting a role of intestinal dysfunction in a number of autoimmune diseases. Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease with a documented increased level of intestinal inflammation, whereas multiple ...
Bitte Sjöström, Anders Bredberg, Thomas Mandl, Lucía Alonso-Magdalena, Bodil Ohlsson, Shahram Lavasani, Mehrnaz Nouri, Gunnel Henriksson   +7 more
doaj   +1 more source

Differences in intestinal size, structure, and function contributing to feed efficiency in broiler chickens reared at geographically distant locations [PDF]

, 2019
The contribution of the intestinal tract to differences in residual feed intake (RFI) has been inconclusively studied in chickens so far. It is also not clear if RFI-related differences in intestinal function are similar in chickens raised in different ...
Aschenbach, J., Ball, M. E. E., Ertl, R., Hawken, R. J., Hollmann, M., Lawlor, P. G. [u.v.m.], Magowan, E., Metzler-Zebeli, B. U., Molnár, A., Witter, K.   +9 more
core   +1 more source

Alterations of the Intestinal Permeability are Reflected by Changes in the Urine Metabolome of Young Autistic Children: Preliminary Results

Metabolites, 2022
Several metabolomics-based studies have provided evidence that autistic subjects might share metabolic abnormalities with gut microbiota dysbiosis and alterations in gut mucosal permeability.
Cristina Piras, Michele Mussap, Antonio Noto, Andrea De Giacomo, Fernanda Cristofori, Martina Spada, Vassilios Fanos, Luigi Atzori, Ruggiero Francavilla   +8 more
doaj   +1 more source

Tilivalline- and Tilimycin-Independent Effects of Klebsiella oxytoca on Tight Junction-Mediated Intestinal Barrier Impairment [PDF]

, 2019
Klebsiella oxytoca causes antibiotic-associated hemorrhagic colitis and diarrhea. This was attributed largely to its secreted cytotoxins tilivalline and tilimycin, inductors of epithelial apoptosis.
Bücker, Roland, Fromm, Anja, Fromm, Michael, Gorkiewicz, Gregor, Hering, Nina A., Högenauer, Christoph, Schulzke, Jörg-Dieter, Troeger, Hanno, Zechner, Ellen   +8 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Sauna dehydration as a new physiological challenge model for intestinal barrier function

Scientific Reports, 2021
The intestinal barrier plays a crucial role in maintaining gut health, and an increased permeability has been linked to several intestinal and extra-intestinal disorders. There is an increasing demand for interventions aimed at strengthening this barrier
Maria Fernanda Roca Rubio, Ulrika Eriksson, Robert J. Brummer, Julia König   +3 more
doaj   +1 more source

Chapter Five. Systematic review results by biomarker classifications [PDF]

, 2016
5.1 Markers of Absorption and Permeability Overview 5.2 Markers of Absorption 5.3 Markers of Permeability 5.4 Markers of Digestion 5.5 Markers of Intestinal Inflammation and Intestinal Immune Activation 5.6 Markers of Systemic Inflammation and Systemic ...
Denno, Donna M, Musser, Christine A, Nelson, Zakia C, Tarr, Phillip I, VanBuskirk, Kelley M   +4 more
core   +1 more source

The Dietary Intervention of Transgenic Low-Gliadin Wheat Bread in Patients with Non-Celiac Gluten Sensitivity (NCGS) Showed No Differences with Gluten Free Diet (GFD) but Provides Better Gut Microbiota Profile [PDF]

, 2018
The study evaluated the symptoms, acceptance, and digestibility of bread made from transgenic low-gliadin wheat, in comparison with gluten free bread, in Non-coeliac gluten sensitivity (NCGS) patients, considering clinical/sensory parameters and gut ...
Comino Montilla, Isabel María, García Molina, María Dolores, Giménez, María J., Haro, Carmen, Ozuna Serafini, Carmen Victoria, Pastor, Jorge, Segura Montero, Verónica, Sousa Martín, Carolina, Sánchez León, Susana, Vaquero, Luis, Villatoro, Myriam   +10 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source