Results 111 to 120 of about 128,505 (309)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ

Cell Reports, 2015
Intestinal epithelial homeostasis requires continuous renewal supported by stem cells located in the base of the crypt. Disruption of this balance results in failure to regenerate and initiates tumorigenesis.
Victoria Llado, Yuki Nakanishi, Angeles Duran, Miguel Reina-Campos, Phillip M. Shelton, Juan F. Linares, Tomoko Yajima, Alex Campos, Pedro Aza-Blanc, Michael Leitges, Maria T. Diaz-Meco, Jorge Moscat   +11 more
doaj   +1 more source

Slow cycling intestinal stem cell and Paneth cell responses to Trichinella spiralis infection

, 2020
There is limited information regarding responses by slow cycling stem cells during T. spiralis-induced T-cell mediated intestinal inflammation and how such responses may relate to those of Paneth cells.
Hughes, Kevin R., Sablitzky, Fred, Javkar, Tanvi, Mahida, Yashwant R., Behnke, Jerzy M.   +4 more
core   +1 more source

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source

Investigating the properties of cancer stem cells and epithelial to mesenchymal transition in human prostate cancer

, 2012
In recent years, the cancer stem cell hypothesis has emerged as a compelling but controversial model of cancer progression. Contrary to the clonal evolution model, the cancer stem cell hypothesis postulates that, akin to normal tissues, tumours are ...
Dunning-Foreman, NL
core  

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Current Issues and Regulations in Tendon Regeneration and Musculoskeletal Repair with Mesenchymal Stem Cells

, 2011
Mesenchymal stem cells are multipotent stromal cells residing within the connective tissue of most organs. Their surface phenotype has been well described.
Grange, Simon
core  

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Lgr5+ intestinal stem cell sorting and organoid culture

Animal Models and Experimental Medicine, 2019
Intestinal epithelial stem cells (IESCs) are one of the most rapidly self‐renewing and proliferating adult stem cells. The IESCs reside at the bottom of intestinal and colonic crypts, giving rise to all intestinal epithelial lineages and maintaining ...
Ruixue Liu, Haifeng Li, Juan Cai, Qiang Wei, Xiaonan Han   +4 more
doaj   +1 more source

Sequential cancer mutations in cultured human intestinal stem cells

, 2015
Crypt stem cells represent the cells of origin for intestinal neoplasia. Both mouse and human intestinal stem cells can be cultured in medium containing the stem-cell-niche factors WNT, R-spondin, epidermal growth factor (EGF) and noggin over long time ...
van Jaarsveld, Richard H., Overmeer, Rene M., Clevers, Hans, G. Johan Offerhaus, van Boxtel, Ruben, Offerhaus, G Johan, Hans Clevers, Kops, Geert J. P. L., Sachs, Norman, Offerhaus, G. Johan, Begthel, Harry, Kops, Geert J P L, Ruben van Boxtel, Jeroen Korving, Edwin Cuppen, Norman Sachs, Harry Begthel, Buijs, Arjan, van Jaarsveld, Richard H, Overmeer, René M, Korving, Jeroen, Ponsioen, Bas, Medema, Jan Paul, Gerald Schwank, Snippert, Hugo J., Richard H. van Jaarsveld, van de Wetering, Marc, René M. Overmeer, Arjan Buijs, Logtenberg, Meike, Marc van de Wetering, Hugo J. Snippert, Jan Paul Medema, Zimberlin, Cheryl, Jarno Drost, Snippert, Hugo J, Bas Ponsioen, Drost, Jarno, Meike Logtenberg, Schwank, Gerald, Cuppen, Edwin, Geert J. P. L. Kops, Cheryl Zimberlin   +42 more
core   +1 more source