Results 121 to 130 of about 128,505 (309)
SPG4 and Dementia: Expanding the Clinical Spectrum
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza +19 more
wiley +1 more source
Investigations into the in vitro developmental plasticity of adult mesenchymal stem cells [PDF]
, 2006 Bone marrow (BM) derived stem cells contribute to the regeneration of diverse adult tissues including heart, liver and brain following BM transplantation.
Croft, Adam P., Croft, Adam P
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Regulation and plasticity of intestinal stem cells during homeostasis and regeneration
, 2016 The intestinal epithelium is the fastest renewing tissue in mammals and has a large flexibility to adapt to different types of damage. Lgr5(+) crypt base columnar (CBC) cells act as stem cells during homeostasis and are essential during regeneration ...
Clevers, Hans, Beumer, Joep
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan +5 more
wiley +1 more source
Stem cells in homeostasis and cancer of the gut
Molecular Cancer, 2019 The intestinal epithelial lining is one of the most rapidly renewing cell populations in the body. As a result, the gut has been an attractive model to resolve key mechanisms in epithelial homeostasis.
Maartje van der Heijden, Louis Vermeulen
doaj +1 more source
, 2010 In the small intestine, stem cells are considered to exist at the bottom of the crypt. Actively proliferatingtransitional cells supplied from stem cells are differentiated into two directions upward and downward.
Fujimori, Takahiro +2 more
core
, 2011 A frequent complication in colorectal cancer (CRC) is regeneration of the tumor after therapy. Here, we report that a gene signature specific for adult intestinal stem cells (ISCs) predicts disease relapse in CRC patients.
Merlos-Suárez, Anna +45 more
core +1 more source
Prominent Movement Disorders in RNU2‐2‐Related Spliceosomopathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Pediatric movement disorders often overlap with neurodevelopmental diseases, suggesting shared molecular mechanisms. Variants in small nuclear RNA (snRNA) genes encoding spliceosome components have recently been associated with neurodevelopmental disorders, termed “RNUopathies.” We analyzed genome sequencing data from 14 patients with ...
Magdalena Krygier +6 more
wiley +1 more source
The TRF1 telomere protein is essential for the generation and maintenance of iPS cells and marks both pluripotent and adult stem cells [PDF]
, 2013 Englisch: Telomeres are nucleoprotein structures that protect the chromosomal ends from being recognized by DNA repair mechanisms as DNA double strand breaks. The Telomeric DNA is bound by various proteins that force the whole structure to fold in the so-
Schneider, Ralph Philipp
core +1 more source
Advanced Engineering Materials, EarlyView.This review highlights advances in lightweight, lead‐free polymer nanocomposites for diagnostic X‐ray shielding. By linking filler chemistry, dispersion, architecture, and photon interaction mechanisms, it establishes structure–performance relationships guiding material design.
Aklilu G. Messele +2 more
wiley +1 more source