A rhodanine agent active against non-replicating intracellular Mycobacterium avium subspecies paratuberculosis. [PDF]
, 2009 BACKGROUND: Antibiotic therapy targeting chronic mycobacterial disease is often ineffective due to problems with the emergence of drug resistance and non-replicating persistent intracellular antibiotic resistant phenotypes.
Bull, TJ +3 more
core +3 more sources
Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids. [PDF]
, 2016 The beta amyloid (Aβ) and other aggregating proteins in the brain increase with age and are frequently found within neurons. The mechanistic relationship between intracellular amyloid, aging and neurodegeneration is not, however, well understood.
Currais, Antonio +5 more
core +2 more sources
Transiently Transfected Purine Biosynthetic Enzymes Form Stress Bodies [PDF]
, 2013 It has been hypothesized that components of enzymatic pathways might organize into intracellular assemblies to improve their catalytic efficiency or lead to coordinate regulation.
Cook, Lindsey +5 more
core +7 more sources
Chlamydial infection from outside to inside [PDF]
, 2019 Chlamydia are obligate intracellular bacteria, characterized by a unique biphasic developmental cycle. Specific interactions with the host cell are crucial for the bacteria's survival and amplification because of the reduced chlamydial genome.
Gitsels, Arlieke +2 more
core +2 more sources
Executive Privilege in the Federal Courts [PDF]
, 1962 Apoptosis is one type of programmed cell death, important during tissue development and to maintain the tissue homeostasis. Apoptosis comprises a complex network of internal signaling pathways, and an important part of this signaling network is the ...
Hardin, Paul, III
core +2 more sources
Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. [PDF]
, 2016 Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood.
Braas, Daniel +4 more
core +1 more source
Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles
Nanoscale Research Letters, 2018 Nanoparticle science is rapidly changing the landscape of various scientific fields and defining new technological platforms. This is perhaps even more evident in the field of nanomedicine whereby nanoparticles have been used as a tool for the treatment ...
Parisa Foroozandeh, A. Aziz
semanticscholar +1 more source
Activation of the Listeria monocytogenes Virulence Program by a Reducing Environment. [PDF]
, 2017 Upon entry into the host cell cytosol, the facultative intracellular pathogen Listeria monocytogenes coordinates the expression of numerous essential virulence factors by allosteric binding of glutathione (GSH) to the Crp-Fnr family transcriptional ...
Aaron T. Whiteley +5 more
core +2 more sources
Intracellular Staphylococcus aureus persisters upon antibiotic exposure
Nature Communications, 2020 Bacterial persister cells are phenotypic variants that exhibit a transient non-growing state and antibiotic tolerance. Here, we provide in vitro evidence of Staphylococcus aureus persisters within infected host cells.
Frédéric Peyrusson +8 more
semanticscholar +1 more source
Intracellular sensing of viral genomes and viral evasion
Experimental and Molecular Medicine, 2019 During viral infection, virus-derived cytosolic nucleic acids are recognized by host intracellular specific sensors. The efficacy of this recognition system is crucial for triggering innate host defenses, which then stimulate more specific adaptive ...
Hyun-Cheol Lee +2 more
semanticscholar +1 more source