Results 91 to 100 of about 2,992,178 (408)
Mid-infrared Chemical Imaging of Intracellular Tau Fibrils using Fluorescence-guided Computational Photothermal Microscopy [PDF]
arXiv, 2023 Amyloid proteins are associated with a broad spectrum of neurodegenerative diseases. However, it remains a grand challenge to extract molecular structure information from intracellular amyloid proteins in their native cellular environment. To address this challenge, we developed a computational chemical microscope integrating 3D mid-infrared ...
arxiv
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Emergent Spatiotemporal Organization in Stochastic Intracellular Transport Dynamics [PDF]
arXiv, 2023 The interior of a living cell is an active, fluctuating, and crowded environment. Yet, it maintains a high level of coherent organization, which is readily apparent in the intracellular transport network. Membrane-bound compartments called endosomes play a key role in carrying cargo, in conjunction with myriad components including cargo adaptor ...
arxiv
Nanogels with Selective Intracellular Reactivity for Intracellular Tracking and Delivery
Chemistry – A European Journal, 2020 AbstractA multimodal approach for hydrogel‐based nanoparticles was developed to selectively allow molecular conjugated species to either be released inside the cell or remain connected to the polymer network. Using the intrinsic difference in reactivity between esters and amides, nanogels with an amide‐conjugated dye could be tracked intracellularly ...
Guangyue Zu +5 more
openaire +3 more sources
Polyhexamethylene Biguanide and Nadifloxacin Self-Assembled Nanoparticles: Antimicrobial Effects against Intracellular Methicillin-Resistant Staphylococcus aureus [PDF]
, 2018 The treatment of skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus (MRSA) remains a challenge, partly due to localization of the bacteria inside the host’s cells, where antimicrobial penetration and efficacy is limited.
Chivu, A +3 more
core +2 more sources
FEBS Letters, EarlyView.Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez +3 more
wiley +1 more source
Журнал микробиологии, эпидемиологии и иммунобиологии, 2015 Aim. Evaluate immune regulatory properties ofbifidobacteria metabolites during eubiosis and dysbiosis of the human colon. Materials and methods. Anti-cytokine activity of metabolites of bifidobacteria clinical strains and their ability to influence the ...
O. V. Bukharin +5 more
doaj
Superdiffusion dominates intracellular particle motion in the supercrowded space of pathogenic Acanthamoeba castellanii [PDF]
Scientific Reports 5, 11690 (2015), 2015 Acanthamoebae are free-living protists and human pathogens, whose cellular functions and pathogenicity strongly depend on the transport of intracellular vesicles and granules through the cytosol. Using high-speed live cell imaging in combination with single-particle tracking analysis, we show here that the motion of endogenous intracellular particles ...
arxiv
Mitochondrial Ca2+ uptake in skeletal muscle health and disease [PDF]
, 2016 Muscle uses Ca2+ as a messenger to control contraction and relies on ATP to maintain the intracellular Ca2+ homeostasis. Mitochondria are the major sub-cellular organelle of ATP production. With a negative inner membrane potential, mitochondria take up Ca2+ from their surroundings, a process called mitochondrial Ca2+ uptake.
arxiv +1 more source
Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue.
Biochemical Journal, 1955 more acidic solutions, with pH < 7 0, a few seconds elapsed before equilibrium was attained. Taking into account the ionization of the haem-linked group on MetMb and the higher oxidation state, the variation of Kb,.
B. C. D. Duve +4 more
semanticscholar +1 more source