Results 111 to 120 of about 1,440,422 (323)

Сomparative characteristics of cytokine profile induced in vitro by supernatants of industrial and intestinal strains of bifido- and lactobacteria

Медицинская иммунология
The immunomodulatory properties of probiotics largely depend on the metabolites secreted into the culture medium, which is studied as a cell-free supernatant and referred to as postbiotics. The aim of the present work was to conduct screening of cytokine
O. V. Bukharin, E. V. Ivanova, I. N. Chaynikova, N. B. Perunova, T. A. Bondarenko, A. V. Bekpergenova   +5 more
doaj   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Intracellular bioactivity of macrolides [PDF]

Clinical Microbiology and Infection, 1996
A brief overview is provided of the bioactivity of macrolides against a range of bacterial species. Topics considered include the cellular pharmacokinetics of uptake and efflux of these drugs and the importance of intra- or extracellular and cytoplasmic or granular location on their activity.
openaire   +3 more sources

Poly I:C Delivery into J774.1 & RAW264.7 Macrophages Induces Rapid Cell Death [PDF]

Iranian Journal of Immunology, 2017
Background: Cytosolic double-stranded RNA (dsRNA) is an important ‘molecular signature’ for the detection of intracellular viral infections. Although intracellular dsRNA is a known potent inducer of apoptosis, the optimal time and dose for the onset of ...
Cheah Wen Yapp, Amal Widaad Mohaimin, Adi Idris   +2 more
doaj  

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Palmitoylation of ULK1 by ZDHHC13 plays a crucial role in autophagy

Nature Communications
Autophagy is a highly conserved process from yeast to mammals in which intracellular materials are engulfed by a double-membrane organelle called autophagosome and degrading materials by fusing with the lysosome.
Keisuke Tabata, Kenta Imai, Koki Fukuda, Kentaro Yamamoto, Hayato Kunugi, Toshiharu Fujita, Tatsuya Kaminishi, Christian Tischer, Beate Neumann, Sabine Reither, Fatima Verissimo, Rainer Pepperkok, Tamotsu Yoshimori, Maho Hamasaki   +13 more
doaj   +1 more source

Tuning the kinetics of intracellular transport [PDF]

arXiv
A variety of complex mechanisms, from chemical reaction pathways to active fluctuations, orchestrate molecular transport in intracellular environments. Despite significant recent progress in visualizing and probing these processes, little is known about how tunable the resulting dynamics is through external physical controllers.
arxiv  

Intracellular Amounts of Nucleic Acids and Protein During Pollen Grain Growth in Tradescantia [PDF]

, 1958
John Woodard
openalex   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Intracellular Communication [PDF]

Molecular Plant, 2014
Grimm, Bernhard, Dehesh, Kayatoon, Zhang, Lixin, Leister, Dario   +3 more
openaire   +2 more sources