Frontiers in Neuroscience, 2023 Calcium (Ca2+) comprises a critical ionic second messenger in the central nervous system that is under the control of a wide array of regulatory mechanisms, including organellar Ca2+ stores, membrane channels and pumps, and intracellular Ca2+-binding ...
Benjamin Klocke +5 more
doaj +1 more source
Molecules, 2011 Many studies on intracellular calcium ([Ca2+]i) and intracellular pH (pHi) have been carried out due to their importance in regulation of different cellular functions. However, most of the previous studies are focused on human or mammalian cells.
Yan-Bo Zhang +4 more
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Decavanadate displaces inositol 1,4,5-trisphosphate (IP3) from its receptor and inhibits IP3 induced Ca2+ release in permeabilized pancreatic acinar cells [PDF]
, 1991 Inositol 1,4,5-trisphosphate (IP3) induced Ca2+ release in digitonin permeabilized rat pancreatic acinar cells is specifically inhibited by decavanadate.
M. Gratzl +9 more
core +1 more source
Interaction between age and obesity on cardiomyocyte contractile function: role of leptin and stress signaling. [PDF]
PLoS ONE, 2010 This study was designed to evaluate the interaction between aging and obesity on cardiac contractile and intracellular Ca2+ properties.Cardiomyocytes from young (4-mo) and aging (12- and 18-mo) male lean and the leptin deficient ob/ob obese mice were ...
Jun Ren +6 more
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Endothelin and increased contractility in adult rat ventricular myocytes. Role of intracellular alkalosis induced by activation of the protein kinase C-dependent Na(+)-H+ exchanger [PDF]
, 1991 Endothelin, a 21-amino acid vasoactive peptide, is among the most potent positively inotropic agents yet described in mammalian heart. Having demonstrated that endothelin's inotropic effect is due, in part, to an apparent sensitization of cardiac ...
Smith, T. W. +2 more
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Calmodulin: a highly conserved and ubiquitous Ca2+ sensor
Proceedings of the Japan Academy. Series B, Physical and Biological SciencesCalcium ions (Ca2+) play critical roles in various biological phenomena. The free Ca2+ concentration in the cytoplasm of a resting cell is at the 10-7 M level, whereas that outside the cell is 10-3 M, creating a 10,000-fold gradient of Ca2 ...
Kenji SOBUE
doaj +1 more source
Ryanodine receptors, a family of intracellular calcium ion channels, are expressed throughout early vertebrate development [PDF]
, 2011 Background Calcium signals ([Ca2+]i) direct many aspects of embryo development but their regulation is not well characterised. Ryanodine receptors (RyRs) are a family of intracellular Ca2+ release channels that control the flux of Ca2+ from internal ...
Ashworth, R +8 more
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Frontiers in Physiology, 2020 Voltage-dependent Ca2+ channels and store-operated Ca2+ channels (SOCs) are the major routes of Ca2+ entry into mammalian cells. Previously, we reported that pharmacological preconditioning (PPC) leads to a decrease in the amplitude of L-type calcium ...
Raúl Sampieri +5 more
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Orai1 is an Entotic Ca2+ Channel for Non‐Apoptotic Cell Death, Entosis in Cancer Development
Advanced Science, 2023 Entosis is a non‐apoptotic cell death process that forms characteristic cell‐in‐cell structures in cancers, killing invading cells. Intracellular Ca2+ dynamics are essential for cellular processes, including actomyosin contractility, migration, and ...
Ah Reum Lee, Chan Young Park
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source