Results 41 to 50 of about 791,437 (254)

Histamine activates an intracellular Ca2+ signal in normal human lung fibroblast WI-38 cells

Frontiers in Cell and Developmental Biology, 2022
Histamine is an inflammatory mediator that can be released from mast cells to induce airway remodeling and cause persistent airflow limitation in asthma.
Roberto Berra-Romani, Ajelet Vargaz-Guadarrama, Josué Sánchez-Gómez, Nayeli Coyotl-Santiago, Efraín Hernández-Arambide, José Everardo Avelino-Cruz, Mario García-Carrasco, Monica Savio, Giorgia Pellavio, Umberto Laforenza, Alfredo Lagunas-Martínez, Francesco Moccia   +11 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Endothelin-Induced Sarcoplasmic Reticulum Calcium Depletion Waves in Vascular Smooth Muscle Cells [PDF]

, 2011
Agonist-stimulated waves of elevated cytoplasmic Ca2+ concentration ([Ca2+]i ) regulate blood vessel tone and vasomotion in vascular smooth muscle. Previous studies employing cytoplasmic Ca2+ indicators revealed that these Ca2+ waves were generated by a ...
Cornelis van Breemen, Jeremy Hoskins, Arash Y. Tehrani, Mitra Esfandiarei, Yohan Choi, Nicola Fameli, Jeremy G. Hoskins, Arash Tehrani   +7 more
core   +1 more source

β adrenergic receptor/cAMP/PKA signaling contributes to the intracellular Ca2+ release by tentacle extract from the jellyfish Cyanea capillata

BMC Pharmacology and Toxicology, 2017
Background Intracellular Ca2+ overload induced by extracellular Ca2+ entry has previously been confirmed to be an important mechanism for the cardiotoxicity as well as the acute heart dysfunction induced by jellyfish venom, while the underlying mechanism
Qianqian Wang, Hui Zhang, Bo Wang, Chao Wang, Liang Xiao, Liming Zhang   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Stimulation of Na⁺/H⁺ Exchanger Isoform 1 Promotes Microglial Migration [PDF]

, 2013
Regulation of microglial migration is not well understood. In this study, we proposed that Na+/H+ exchanger isoform 1 (NHE-1) is important in microglial migration.
Cengiz, P, Yuan Hui, Baba, Akemichi, Vishal Chanana, Chanana, V, Dong Kim (443919), Shi Yejie, Sun Dandan, Dandan Sun, Zhang, Zhe, Hui Yuan, Sun, Dandan, Toshio Matsuda, Yejie Shi, Akemichi Baba, An Sun, Matsuda Toshio, Peter Ferrazzano, Matsuda, Toshio, Pelin Cengiz, Akemichi Baba (253010), Baba, A, Shi, Y, Ferrazzano, Peter, Ferrazzano Peter, Hui Yuan (402180), Kim, Dong, Dong Kim, Sun, D, Vishal Chanana (448559), Shi, Yejie, Cengiz, Pelin, Toshio Matsuda (448560), Ferrazzano, P, Matsuda, T, Yuan, H, Peter Ferrazzano (448562), Dandan Sun (448563), Kim, D, Chanana, Vishal, Baba Akemichi, Pelin Cengiz (448561), Cengiz Pelin, Yuan, Hui, Yejie Shi (448558), Kim Dong, Chanana Vishal   +46 more
core   +2 more sources

Evidence for altered Ca2+ handling in Growth Associated Protein 43-knockout skeletal muscle

Frontiers in Physiology, 2016
Neuronal growth-associated protein 43 (GAP43) has crucial roles in the nervous system, and during development, regeneration after injury, and learning and memory.
Giusy A. Caprara, Giusy A. Caprara, Caterina Morabito, Caterina Morabito, Stefano Perni, Riccardo Navarra, Simone Guarnieri, Simone Guarnieri, Maria A. Mariggiò, Maria A. Mariggiò   +9 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Functional expression of TRPV4 channels in human collecting duct cells : implications for secondary hypertension in diabetic nephropathy [PDF]

, 2012
Background. The Vanilloid subfamily of transient receptor potential (TRPV) ion channels has been widely implicated in detecting osmotic and mechanical stress.
Hills, Claire E., Bland, Rosemary, Squires, Paul E.   +2 more
core   +1 more source