Results 221 to 230 of about 258,180 (266)

Vaccines against Intracellular Pathogens

2000
Vaccination against intracellular pathogens presents unique problems that are specific to the growth environment used by these organisms. For all vaccines it is important to determine the best antigen(s) and inoculation method that will induce the proper strength and type of immune response as well as protect against subsequent challenge.
R G, Barletta, R O, Donis, O, Chacón, H, Shams, J D, Cirillo   +4 more
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INTRACELLULAR PATHOGENS AND THE ACTIN CYTOSKELETON

Annual Review of Cell and Developmental Biology, 1998
▪ Abstract  Many pathogens actively exploit the actin cytoskeleton during infection. This exploitation may take place during entry into mammalian cells after engagement of a receptor and/or as series of signaling events culminating in the engulfment of the microorganism. Although actin rearrangements are a common feature of most internalization events
Dramsi, S., Cossart, P.
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Phagolysosomal escape by intracellular pathogens

Parasitology Today, 1991
It has often been suggested that intracellular parasites invade cells in order to evade the host's immune response. Whether or not this view is correct, have successfully avoided excessive scrutiny by biomedical investigators. Published descriptions of the intracellular compartments occupied by parasites often contradict each other, reflecting the fact
N W, Andrews, P, Webster
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Cytoplasmic access by intracellular bacterial pathogens

Trends in Microbiology, 2014
Entry into host cells is a strategy widely used by bacterial pathogens, after which they either remain within membrane-bound compartments or rupture the endocytic vacuole to reach the cytoplasm. During recent years, cytoplasmic access has been documented for an increasing number of pathogens. Here we review how classical cytoplasmic bacterial pathogens
Jennifer Fredlund, Jost Enninga
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Targeted therapy for intracellular pathogens

Trends in Parasitology, 2001
Exploitation of CD40 ligand (CD40L) has been proposed as a novel vaccine strategy to combat intracellular pathogens. G. Chen et al. (2001) (Infect. Immun. 69, 3255–3263) report that injecting a combination of CD40L and Leishmania-derived antigen into mice is an effective way to preferentially induce type 1 (cell-mediated) immune responses to the ...
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Vaccines against intracellular bacterial pathogens

Drug Discovery Today, 2008
There is a long history of remarkable success in developing vaccines against bacteria that are extracellular pathogens. In general, the development of vaccines against intracellular bacterial pathogens has proven to be more challenging. Typically, such vaccines need to induce a range of immune responses, including antibody, CD4(+) and CD8(+) T cell ...
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Sensing intracellular pathogens—NOD-like receptors

Current Opinion in Pharmacology, 2008
The innate immune system uses different molecules that sense pathogen associated molecular patterns. These include Toll-like receptors (TLRs), RIG-1-like receptors (RLRs) and the NOD-like receptors (NLRs). The NLRs, consisting of more than 20 related family members, are present in the cytosol and recognize intracellular ligands.
Svend T, Rietdijk, Timothy, Burwell, John, Bertin, Anthony J, Coyle   +3 more
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Actin-based motility of intracellular pathogens

Current Opinion in Microbiology, 2005
The actin cytoskeleton is harnessed by several pathogenic bacteria that are capable of entering into non-phagocytic cells, the so-called 'invasive bacteria'. Among them, a few also exploit the host actin cytoskeleton to move intra- and inter-cellularly. Our knowledge of the basic mechanisms underlying actin-based motility has dramatically increased and
Gouin, Edith, Welch, Matthew, Cossart, Pascale   +2 more
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Use of Fluoroquinolones for Intracellular Pathogens

Clinical Infectious Diseases, 1989
Current microbiologic techniques (determinations of minimal inhibitory and/or microbicidal concentrations) are unable to delineate the true role of anti-infectious drugs in the treatment of human infections due to intracellular pathogens. The prediction and evaluation of the efficacy of quinolones against intracellular pathogens requires information on
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Phenotypic modulation by intracellular bacterial pathogens

Electrophoresis, 1999
Microorganisms have the capacity to sense their environment and to respond to it by alteration in gene expression and protein synthesis. Two-dimensional electrophoresis (2-DE) provides a powerful tool to examine the global response in bacterial protein synthesis upon exposure to different environmental signals.
Y A, Kwaik, O S, Harb
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