Results 311 to 320 of about 281,844 (353)

Phagolysosomal escape by intracellular pathogens

Parasitology Today, 1991
It has often been suggested that intracellular parasites invade cells in order to evade the host's immune response. Whether or not this view is correct, have successfully avoided excessive scrutiny by biomedical investigators. Published descriptions of the intracellular compartments occupied by parasites often contradict each other, reflecting the fact
N W, Andrews, P, Webster
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Exit strategies of intracellular pathogens

Nature Reviews Microbiology, 2008
The exit of intracellular pathogens from host cells is an important step in the infectious cycle, but is poorly understood. It has recently emerged that microbial exit is a process that can be directed by organisms from within the cell, and is not simply a consequence of the physical or metabolic burden that is imposed on the host cell.
Kevin, Hybiske, Richard S, Stephens
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Use of Fluoroquinolones for Intracellular Pathogens

Clinical Infectious Diseases, 1989
Current microbiologic techniques (determinations of minimal inhibitory and/or microbicidal concentrations) are unable to delineate the true role of anti-infectious drugs in the treatment of human infections due to intracellular pathogens. The prediction and evaluation of the efficacy of quinolones against intracellular pathogens requires information on
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Immunogenetics in the analysis of resistance to intracellular pathogens

Current Opinion in Immunology, 1995
Recent studies have identified genes involved in resistance to intracellular pathogens. Such genes include the murine MHC class I gene, Ld (toxoplasmosis), HLA-BW53, HLA DRB1* 1302-DQ B10s01 and TNF2 (malaria), murine Nramp (toxoplasmosis, leishmaniasis and tuberculosis), gene(s) modulating the T-helper type 1 and type 2 dichotomy (leishmaniasis ...
R, McLeod, E, Buschman, L D, Arbuckle, E, Skamene   +3 more
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Vaccines against Intracellular Pathogens

2000
Vaccination against intracellular pathogens presents unique problems that are specific to the growth environment used by these organisms. For all vaccines it is important to determine the best antigen(s) and inoculation method that will induce the proper strength and type of immune response as well as protect against subsequent challenge.
R G, Barletta, R O, Donis, O, Chacón, H, Shams, J D, Cirillo   +4 more
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Targeted therapy for intracellular pathogens

Trends in Parasitology, 2001
Exploitation of CD40 ligand (CD40L) has been proposed as a novel vaccine strategy to combat intracellular pathogens. G. Chen et al. (2001) (Infect. Immun. 69, 3255–3263) report that injecting a combination of CD40L and Leishmania-derived antigen into mice is an effective way to preferentially induce type 1 (cell-mediated) immune responses to the ...
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Cytoplasmic access by intracellular bacterial pathogens

Trends in Microbiology, 2014
Entry into host cells is a strategy widely used by bacterial pathogens, after which they either remain within membrane-bound compartments or rupture the endocytic vacuole to reach the cytoplasm. During recent years, cytoplasmic access has been documented for an increasing number of pathogens. Here we review how classical cytoplasmic bacterial pathogens
Jennifer Fredlund, Jost Enninga
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Mitochondria as sensors of intracellular pathogens

Trends in Endocrinology & Metabolism
Mitochondria must sense their environment to enable cells and organisms to adapt to diverse environments and survive during stress. However, during microbial infection, an evolutionary pressure since the inception of the eukaryotic cell, these organelles are traditionally viewed as targets for microbes.
Delgado, Jose M., Pernas, Lena
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The Challenge of Intracellular Pathogens

New England Journal of Medicine, 1992
THE survival of intracellular pathogens in the host depends on their ability to avoid being killed before or after they invade mononuclear phagocytes; these cells are critical in this respect.
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Probing the microenvironment of intracellular bacterial pathogens

Microbes and Infection, 1999
The identification of bacterial genes regulated in response to the intracellular environment is crucial to the understanding of host-pathogen interactions. Several techniques have been developed to identify and characterize bacterial genes that are induced during the intracellular infection and, potentially, may play a role in pathogenesis. This review
O S, Harb, Y, Abu Kwaik
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