Results 11 to 20 of about 181,797 (206)

Effect of Protein Denaturation and Enzyme Inhibitors on Proteasomal-Mediated Production of Peptides in Human Embryonic Kidney Cells

Biomolecules, 2019
Peptides produced by the proteasome have been proposed to function as signaling molecules that regulate a number of biological processes. In the current study, we used quantitative peptidomics to test whether conditions that affect protein stability ...
Sayani Dasgupta, Michael A. Fishman, Leandro M. Castro, Alexandre K. Tashima, Emer S. Ferro, Lloyd D. Fricker   +5 more
doaj   +1 more source

Targeting GABAAR-Associated Proteins: New Modulators, Labels and Concepts

Frontiers in Molecular Neuroscience, 2019
γ-aminobutyric acid type A receptors (GABAARs) are the major mediators of synaptic inhibition in the brain. Aberrant GABAAR activity or regulation is observed in various neurodevelopmental disorders, neurodegenerative diseases and mental illnesses ...
Vladimir Khayenko, Vladimir Khayenko, Hans Michael Maric, Hans Michael Maric   +3 more
doaj   +1 more source

Potential of known and short prokaryotic protein motifs as a basis for novel peptide-based antibacterial therapeutics: a computational survey.

Frontiers in Microbiology, 2014
Short linear motifs are functional stretches of protein sequence that are of crucial importance for numerous biological processes by mediating protein-protein interactions.
Heini eRuhanen, Heini eRuhanen, Heini eRuhanen, Daniel eHurley, Daniel eHurley, Daniel eHurley, Ambarnil eGhosh, Kevin T O'Brien, Kevin T O'Brien, Kevin T O'Brien, Catrióna R Johnston, Denis Colum Shields, Denis Colum Shields, Denis Colum Shields   +13 more
doaj   +1 more source

Relationships between Cargo, Cell Penetrating Peptides and Cell Type for Uptake of Non-Covalent Complexes into Live Cells

Pharmaceuticals, 2013
Modulating signaling pathways for research and therapy requires either suppression or expression of selected genes or internalization of proteins such as enzymes, antibodies, nucleotide binding proteins or substrates including nucleoside phosphates and ...
Andrea-Anneliese Keller, Franziska Mussbach, Reinhard Breitling, Peter Hemmerich, Buerk Schaefer, Stefan Lorkowski, Siegmund Reissmann   +6 more
doaj   +1 more source

Homozygosity for a partial deletion of apoprotein A-V signal peptide results in intracellular missorting of the protein and chylomicronemia in a breast-fed infant

Atherosclerosis, 2014
Deficiency of apoprotein A-V (apoA-V) can cause hypertriglyceridemia. In an 11 months old boy presenting with a severe hypertriglyceridemia, a formerly unknown 24 nucleotide deletion in exon 2 of the APOA5 gene was detected. The homozygous mutation results in an eight amino acid loss in the signal peptide sequence (c.16_39del; p.Ala6_Ala13del ...
Albers, Kirstin, Schlein, Christian, Wenner, Kirsten, Lohse, Peter, Bartelt, Alexander, Heeren, Joerg, Santer, René, Merkel, Martin   +7 more
openaire   +2 more sources

Evolution of KIPPIS as a versatile platform for evaluating intracellularly functional peptide aptamers

Scientific Reports, 2021
Chimeric proteins have been widely used to evaluate intracellular protein–protein interactions (PPIs) in living cells with various readouts. By combining an interleukin-3-dependent murine cells and chimeric proteins containing a receptor tyrosine kinase ...
Daiki Kashima, Masahiro Kawahara
doaj   +1 more source

Theoretical and Computational Studies of Peptides and Receptors of the Insulin Family

Membranes, 2015
Synergistic interactions among peptides and receptors of the insulin family are required for glucose homeostasis, normal cellular growth and development, proliferation, differentiation and other metabolic processes. The peptides of the insulin family are
Harish Vashisth
doaj   +1 more source

A Global Review on Short Peptides: Frontiers and Perspectives

Molecules, 2021
Peptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains of life and interfere with protein-protein interactions, which are indispensable in bio-processes.
Vasso Apostolopoulos, Joanna Bojarska, Tsun-Thai Chai, Sherif Elnagdy, Krzysztof Kaczmarek, John Matsoukas, Roger New, Keykavous Parang, Octavio Paredes Lopez, Hamideh Parhiz, Conrad O. Perera, Monica Pickholz, Milan Remko, Michele Saviano, Mariusz Skwarczynski, Yefeng Tang, Wojciech M. Wolf, Taku Yoshiya, Janusz Zabrocki, Piotr Zielenkiewicz, Maha AlKhazindar, Vanessa Barriga, Konstantinos Kelaidonis, Elham Mousavinezhad Sarasia, Istvan Toth   +24 more
doaj   +1 more source

Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress

eLife, 2020
Disruption of protein folding in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR)—a signaling network that ultimately determines cell fate.
Mable Lam, Scot A Marsters, Avi Ashkenazi, Peter Walter   +3 more
doaj   +1 more source

Towards the systematic discovery of signal transduction networks using phosphorylation dynamics data

BMC Bioinformatics, 2010
Background Phosphorylation is a ubiquitous and fundamental regulatory mechanism that controls signal transduction in living cells. The number of identified phosphoproteins and their phosphosites is rapidly increasing as a result of recent mass ...
Yachie Nozomu, Imamura Haruna, Saito Rintaro, Ishihama Yasushi, Tomita Masaru   +4 more
doaj   +1 more source