Results 21 to 30 of about 181,797 (206)

Molecular Dynamics Simulations Reveal Canonical Conformations in Different pMHC/TCR Interactions

Cells, 2020
The major defense system against microbial pathogens in vertebrates is the adaptive immune response and represents an effective mechanism in cancer surveillance. T cells represent an essential component of this complex system.
Josephine Alba, Lorenzo Di Rienzo, Edoardo Milanetti, Oreste Acuto, Marco D’Abramo   +4 more
doaj   +1 more source

Host intracellular signaling events and pro-inflammatory cytokine production in African trypanosomiasis

Frontiers in Immunology, 2016
Pathogens such as bacteria, viruses and parasites possess specific molecules or proteins that are recognized by several host innate immune receptors leading to the activation of several intracellular signaling molecules and pathways.
Shiby M Kuriakose, Rani eSingh, JUDE EZEH UZONNA   +2 more
doaj   +1 more source

Effects of frog skin peptide temporin-1CEa and its analogs on ox-LDL induced macrophage-derived foam cells

Frontiers in Pharmacology, 2023
Purpose: Atherosclerosis is one of the most important pathological foundations of cardiovascular and cerebrovascular diseases with high morbidity and mortality.
Xue-Feng Yang, Xue-Feng Yang, Xin Liu, Xiao-Yi Yan, De-Jing Shang   +4 more
doaj   +1 more source

Regulation of dermal fibroblasts by human neutrophil peptides

Scientific Reports, 2023
Human neutrophil peptides (HNPs) can induce cell proliferation and activation so their growth promoting activities may have potential clinical benefit. This study investigated the effects of HNPs on human dermal fibroblasts.
Nattarika Niwetbowornchai, Thanawat Chaisirirat, Sira Sriswasdi, Supichcha Saithong, Grace Filbertine, Helen L. Wright, Steven W. Edwards, Sita Virakul, Direkrit Chiewchengchol   +8 more
doaj   +1 more source

Pathophysiology of GPCR Homo- and Heterodimerization: Special Emphasis on Somatostatin Receptors

Pharmaceuticals, 2012
G-protein coupled receptors (GPCRs) are cell surface proteins responsible for translating >80% of extracellular reception to intracellular signals.
Rishi K. Somvanshi, Ujendra Kumar
doaj   +1 more source

Resistance to Inhibitors of Cholinesterase 3 (Ric-3) Expression Promotes Selective Protein Associations with the Human α7-Nicotinic Acetylcholine Receptor Interactome. [PDF]

PLoS ONE, 2015
The α7-nicotinic acetylcholine receptor (α7-nAChR) is a ligand-gated ion channel widely expressed in vertebrates and is associated with numerous physiological functions.
Matthew J Mulcahy, Sydney B Blattman, Francisco J Barrantes, Ronald J Lukas, Edward Hawrot   +4 more
doaj   +1 more source

A Multimodal Platform for Simultaneous T-cell Imaging, Defined Activation, and Mechanobiological Characterization

Cells, 2021
T-cell antigen recognition is accompanied by extensive morphological rearrangements of the contact zone between the T-cell and the antigen-presenting cell (APC).
Martin Fölser, Viktoria Motsch, René Platzer, Johannes B. Huppa, Gerhard J. Schütz   +4 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Calcitonin Peptide Family Members Are Differentially Regulated by LPS and Inhibit Functions of Rat Alveolar NR8383 Macrophages.

PLoS ONE, 2016
Members of the calcitonin peptide family-calcitonin gene-related peptide (CGRP), adrenomedullin (AM), and adrenomedullin2/intermedin (IMD)-exert modulatory effects upon monocytes and macrophages of various extrapulmonary origins.
Aichurek Soultanova, Zbigniew Mikulski, Uwe Pfeil, Veronika Grau, Wolfgang Kummer   +4 more
doaj   +1 more source