Agent-based modeling of intracellular transport [PDF]
, 2018 We develop an agent-based model of the motion and pattern formation of vesicles. These intracellular particles can be found in four different modes of (undirected and directed) motion and can fuse with other vesicles. While the size of vesicles follows a
Birbaumer, M., Schweitzer, F.
core
Tango1L but not Tango1S, Tali and cTAGE5 is required for export of type II collagen in medaka fish
Cell Structure and FunctionNewly synthesized proteins destined for the secretory pathway are folded and assembled in the endoplasmic reticulum (ER) and then transported to the Golgi apparatus via COPII vesicles, which are normally 60–90 nm.
Yusuke Yasuda +7 more
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Dynein catch bond as a mediator of codependent bidirectional cellular transport
, 2019 Intracellular bidirectional transport of cargo on microtubule filaments is achieved by the collective action of oppositely directed dynein and kinesin motors.
Chandel, Sameep +7 more
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Golgi Fragmentation in Neurodegenerative Diseases: Is There a Common Cause?
Cells, 2019 In most mammalian cells, the Golgi complex forms a continuous ribbon. In neurodegenerative diseases, the Golgi ribbon of a specific group of neurons is typically broken into isolated elements, a very early event which happens before clinical and other ...
José Ángel Martínez-Menárguez +3 more
doaj +1 more source
Impact of physiological ionic strength and crowding on kinesin-1 motility
Cell Structure and FunctionThe motility of biological molecular motors has typically been analyzed by in vitro reconstitution systems using motors isolated and purified from organs or expressed in cultured cells. The behavior of biomolecular motors within cells has frequently been
Misaki Sagawa +4 more
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Spatial control of neuronal metabolism through glucose-mediated mitochondrial transport regulation
eLife, 2018 Eukaryotic cells modulate their metabolism by organizing metabolic components in response to varying nutrient availability and energy demands. In rat axons, mitochondria respond to glucose levels by halting active transport in high glucose regions.
Anamika Agrawal +2 more
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Structure, Function and Regulation of the Hsp90 Machinery
Biomedical Journal, 2013 Heat shock protein 90 (Hsp90) is an ATP-dependent molecular chaperone which is essential in eukaryotes. It is required for the activation and stabilization of a wide variety of client proteins and many of them are involved in important cellular pathways.
Jing Li, Johannes Buchner
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Non-equilibrium forces drive the anomalous diffusion of telomeres in the nucleus of mammalian cells
New Journal of Physics, 2017 Telomeres are vital nucleotide sequences at both ends of each chromosome, and their motion reports on the local dynamics of decondensed chromatin in the nucleus of interphase cells.
Lorenz Stadler, Matthias Weiss
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Collective transport of weakly interacting molecular motors with Langmuir kinetics
, 2015 Filament based intracellular transport involves the collective action of molecular motor proteins. Experimental evidences suggest that microtubule (MT) filament bound motor proteins such as {\it kinesins} weakly interact among themselves during transport
Chandel, Sameep +2 more
core +1 more source
Secondary water pore formation for proton transport in a ClC exchanger revealed by an atomistic molecular dynamics simulation [PDF]
, 2008 Several prokaryotic ClC proteins have been demonstrated to function as exchangers that transport both chloride ions and protons simultaneously in opposite directions.
Won Ho Jo, Youn Jo Ko
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