Results 1 to 10 of about 41,748 (163)

The cellular uptake mechanism, intracellular transportation, and exocytosis of polyamidoamine dendrimers in multidrug-resistant breast cancer cells [PDF]

International Journal of Nanomedicine, 2016
Jie Zhang,1 Dan Liu,1 Mengjun Zhang,1 Yuqi Sun,1,2 Xiaojun Zhang,1 Guannan Guan,1 Xiuli Zhao,1 Mingxi Qiao,1 Dawei Chen,1 Haiyang Hu1 1Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 2Department of ...
Zhang J, Liu D, Zhang MJ, Sun YQ, Zhang XJ, Guan GN, Zhao XL, Qiao MX, Chen DW, Hu HY   +9 more
doaj   +2 more sources

Cyclic Peptide-Gadolinium Nanoparticles for Enhanced Intracellular Delivery

Pharmaceutics, 2020
A cyclic peptide containing one cysteine and five alternating tryptophan and arginine amino acids [(WR)5C] was synthesized using Fmoc/tBu solid-phase methodology.
Amir Nasrolahi Shirazi, Shang Eun Park, Shirin Rad, Luiza Baloyan, Dindyal Mandal, Muhammad Imran Sajid, Ryley Hall, Sandeep Lohan, Khalid Zoghebi, Keykavous Parang, Rakesh Kumar Tiwari   +10 more
doaj   +3 more sources

Identification and Characterization of the Glutathione S-Transferase Gene Family in Blueberry (Vaccinium corymbosum) and Their Potential Roles in Anthocyanin Intracellular Transportation [PDF]

Plants
The glutathione S-transferases (GSTs, EC 2.5.1.18) constitute a versatile enzyme family with pivotal roles in plant stress responses and detoxification processes.
Xuxiang Wang, Jiajia Dong, Yiting Hu, Qiaoyu Huang, Xiaoying Lu, Yilin Huang, Mingyang Sheng, Lijun Cao, Buhuai Xu, Yongqiang Li, Yu Zong, Weidong Guo   +11 more
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A Nanotube Injector for Cytoplasmic Transfer and Enhanced Mitochondrial Function [PDF]

Small Science
The intercellular transportation of molecules is crucial for regulating cell communication and function. However, the existing techniques for molecule transfer across cell barriers often cause cellular damage or have low transfer efficiencies. To address
Bingfu Liu, Zhuhang Dai, Bowen Zhang, Kazuhiro Oyama, Chenxi Li, Yukun Chen, Mingyin Cui, Takeo Miyake   +7 more
doaj   +2 more sources

Cyclic Peptide-Gadolinium Nanocomplexes as siRNA Delivery Tools

Pharmaceuticals, 2021
We have recently reported that a cyclic peptide containing five tryptophan, five arginine, and one cysteine amino acids [(WR)5C], was able to produce peptide-capped gadolinium nanoparticles, [(WR)5C]-GdNPs, in the range of 240 to 260 nm upon mixing with ...
Amir Nasrolahi Shirazi, Muhammad Imran Sajid, Dindyal Mandal, David Stickley, Stephanie Nagasawa, Joshua Long, Sandeep Lohan, Keykavous Parang, Rakesh Kumar Tiwari   +8 more
doaj   +1 more source

Amphiphilic Cell-Penetrating Peptides Containing Arginine and Hydrophobic Residues as Protein Delivery Agents

Pharmaceuticals, 2023
The entry of proteins through the cell membrane is challenging, thus limiting their use as potential therapeutics. Seven cell-penetrating peptides, designed in our laboratory, were evaluated for the delivery of proteins.
Jonathan Moreno, Khalid Zoghebi, David Salehi, Lois Kim, Sorour Khayyatnejad Shoushtari, Rakesh K. Tiwari, Keykavous Parang   +6 more
doaj   +1 more source

Intracellular transports and atherogenesis [PDF]

Frontiers in Bioscience, 2020
There is a great progress in understanding the cellular and molecular aspects of atherosclerosis, which is one of the leading causes of death. Yet, there are questions regarding the cellular and metabolic mechanisms that lead to atherogenesis. Among the many factors that influence this process, food plays a significant role.
Alexander A. Mirоnоv, Irina S. Sesorova, Ivan D. Dimov, Natalia R. Karelina, Galina V. Beznoussenko   +4 more
openaire   +3 more sources

Managing intracellular transport [PDF]

Worm, 2013
Formation and normal function of neuronal synapses are intimately dependent on the delivery to and removal of biological materials from synapses by the intracellular transport machinery. Indeed, defects in intracellular transport contribute to the development and aggravation of neurodegenerative disorders.
Chua, J., Jahn, R., Klopfenstein, D.
openaire   +3 more sources

CFTR Deficiency Affects Glucose Homeostasis via Regulating GLUT4 Plasma Membrane Transportation

Frontiers in Cell and Developmental Biology, 2021
Cystic Fibrosis (CF) is an autosomal recessive disorder caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. CF-related diabetes (CFRD) is one of the most prevalent comorbidities of CF.
Junzhong Gu, Weiwei Zhang, Lida Wu, Yuchun Gu, Yuchun Gu   +4 more
doaj   +1 more source

Intracellular Cholesterol Transport [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2004
Intracellular cholesterol transport is essential for the maintenance of cholesterol homeostasis. Many aspects of cholesterol metabolism are well-known, including its synthesis in the endoplasmic reticulum, its extracellular transport in plasma lipoproteins, its uptake by the low-density lipoprotein receptor, and its regulation of SREBP and LXR ...
Raymond E, Soccio, Jan L, Breslow
openaire   +2 more sources