Results 91 to 100 of about 1,288,434 (306)
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Polarity‐selective Transfer of Lipophilic Cargoes From Lipid Droplets (Oleosomes) to Lipid Bilayers
Advanced Materials InterfacesLipid Droplets (LDs) or as also called oleosomes are lipid storage organelles in eukaryotic cells. Besides storing lipids, LDs can fuse their core into other intracellular organelles, but the mechanism remains unknown.
Umay Sevgi Vardar +2 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Long-range transportation plan
, 2004 Cover title.; "Prepared by State of Connecticut, Department of Transportation, Bureau of Policy & Planning ... ; in cooperation with U.S. Department of Transportation, Federal Highway Administration and the Federal Transit Administration"--Table of ...
Connecticut. Dept. of Transportation.
core
Industry Snapshots: Uses of Transportation: 2015 [PDF]
The Bureau of Transportation Statistics (BTS) estimates that transportation directly created $692.0 billion of economic activity by moving goods in 2014.
Firestine, Theresa +1 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Other title: Kansas Department of Transportation Overview Other title: KDOT Overview
, 2013 Title supplied by cataloger from file name.; "January 17, 2013.", Committee names taken from the Kansas Department of Transportation website.; Presentation to the Kansas Legislature, Joint Transportation Committees, by staff of the Kansas Department of ...
Kansas. Department of Transportation.
core +1 more source
Intracellular Ice Formation of Mouse Osteoblasts During Cryopreservation
Zhileng xuebao, 2007 Intracellular ice formation(IIF)is one of the factors that causes cell damage during cryopreservation pro-cess.The study of IIF will provide fundamental information for the development of appropriate cryopreservation proto-cols.The possibility of IIF at ...
John McGrath, Liu Baolin
doaj +2 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source