Results 61 to 70 of about 38,020 (224)

Surgical Approach for Long-term Survival of Patients With Intrahepatic Cholangiocarcinoma: A Multi-institutional Analysis of 434 Patients. [PDF]

, 2012
OBJECTIVES To examine the outcomes of a hepatectomy for intrahepatic cholangiocarcinoma (IHC) and to clarify the prognostic impact of a lymphadenectomy and the surgical margin. Large series of patients who were surgically treated for IHC are scarce. Thus,
Aldrighetti, L, Amisano, M, Berloco, P, Calise, F, Capussotti, L, Gerunda, Giorgio Enrico, Giulini, Sm, Guglielmi, Andrea, Italian, Intrahepatic Cholangiocarcinoma Study Group, Nuzzo, G, Pinna, Antonio Daniele, Ponti, A, Ribero, D, Tomatis, M, Torzilli, G   +14 more
core   +1 more source

Does resection improve overall survival for intrahepatic cholangiocarcinoma with nodal metastases?

Surgery Open Science, 2020
Background: The potential benefit of surgical resection of intrahepatic cholangiocarcinoma in patients with locoregionally advanced disease has not been definitively determined.
Patrick J. Sweigert, MD, Emanuel Eguia, MD, MS, MHA, Haroon Janjua, MS, Sean P. Nassoiy, DO, MS, Lawrence M. Knab, MD, Gerard Abood, MD, MS, Paul C. Kuo, MD, MS, MBA, Marshall S. Baker, MD, MBA   +7 more
doaj   +1 more source

Patterns of chromosomal copy-number alterations in intrahepatic cholangiocarcinoma [PDF]

, 2015
International audienceBackground: Intrahepatic cholangiocarcinomas (ICC) are relatively rare malignant tumors associated with a poor prognosis. Recent studies using genome-wide sequencing technologies have mainly focused on identifying new driver ...
Broët, Philippe, Camilleri-Broët, Sophie, Campos dos Santos, Cedália Rosane, Carpentier, Wassila, Castaing, Denis, Dalmasso, Cyril, Duclos-Vallée, Jean-Charles, Guettier, Catherine, Vendramini Borelli, Wyllians   +8 more
core   +3 more sources

Primary and malignant cholangiocytes undergo CD40 mediated Fas dependent Apoptosis, but are insensitive to direct activation with exogenous fas ligand [PDF]

, 2010
Introduction Cholangiocarcinoma is a rare malignancy of the biliary tract, the incidence of which is rising, but the pathogenesis of which remains uncertain.
A Bergamo, A Eliopoulos, A Ottaiano, A Pickens, AB Alexandroff, AH Klimp, AJ Baxendale, AM Cleary, AR Hayward, B Ansari, C Esche, D Wang, David H. Adams, DG Wingett, E Alabraba, E Bonfoco, E Jakobsen, Elizabeth H. Humphreys, F Mach, FG Que, G Pan, H Dzojic, H Le-Niculescu, HD Ochs, HR Shin, I Cascino, I Stamenkovic, J Ahmed-Choudhury, JL Ferrant, JR Maxwell, K Harada, Kevin T. Williams, KT Williams, LE French, M Fan, MC Rissoan, Mikhail V. Blagosklonny, MV Clement, N Itoh, P Angel, P Chu, P Starkel, P Watanapa, PA Lipsett, R Joplin, R Stewart, RH Vonderheide, RJ Armitage, RS Chapman, S Hess, S Kubo, S Paulie, SA Khan, SC Afford, SC Afford, SC Afford, SC Afford, Simon C. Afford, SM Abmayr, T Ohtsuka, T Shimonishi, T Suda, U Broome, U Bugajska, U Gaur, U Schonbeck, W Schuler, YS Zong   +67 more
core   +3 more sources

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

Intra-arterial PSMA injection using hepatic arterial infusion pump in intrahepatic cholangiocarcinoma: a proof-of-concept study

European Radiology Experimental
Prostate-specific membrane antigen (PSMA) targeted tracers show increased uptake in several malignancies, indicating a potential for peptide radioligand therapy. Intra-arterial injection of radiotracers can increase the therapeutic window.
Mara Marieke Katrien Veenstra, Erik Vegt, Marcel Segbers, Stijn Franssen, Bas Groot Koerkamp, Frederik Anton Verburg, Maarten Guillaume Josephus Thomeer   +6 more
doaj   +1 more source

Increasing mortality in the United States from cholangiocarcinoma: an analysis of the National Center for Health Statistics Database [PDF]

, 2016
CCA Mortality Rate by Year among Asians; raw data file with query terms.
Kaelan J. Yao, Niyati Parekh, Rebecca A. Moss, Salma Jabbour, Yong Lin   +4 more
core   +6 more sources

METTL5 Enables Immune Evasion of Liver Cancer via Chemokine mRNA Translation Regulation

Advanced Science, EarlyView.
METTL5 reshapes the tumor immune microenvironment through ribosome 18S rRNA m6A modification to regulate the translation of chemokine mRNA. Targeting METTL5‐mediated immunosuppression unleashes anti‐tumor immunity and improves the efficacy of anti‐PD‐1 therapy.
Shuang Li, Xiao Zhao, Tongtong Song, Qiaoyi Chen, Yanqing Wu, Yuting Zhang, Jingying Chen, Yifan Wu, Bin Li, Xinyue Zhang, Zihao Dai, Lixia Xu, Yubin Xie, Alfred Sze‐Lok Cheng, Jianping Guo, Ming Kuang, Shuibin Lin, Zhenwei Peng, Sui Peng, Xuezhen Zeng   +19 more
wiley   +1 more source

Durable response from fibroblast growth factor receptor inhibition in intrahepatic cholangiocarcinoma terminated by metachronous acute myeloid leukemia: a case report

Journal of Medical Case Reports, 2023
Introduction Advances in the treatment of biliary tract cancer have been made possible through gains in genomic and epigenetic tumor understanding. The use of fibroblast growth factor receptor inhibitor has enabled significant clinical improvement in a ...
Andreas Edwin Juarso, Stefanie Entz, Florian Weissinger   +2 more
doaj   +1 more source

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source