Results 1 to 10 of about 105,725 (272)

Da-Chai-Hu-Tang Protects From Acute Intrahepatic Cholestasis by Inhibiting Hepatic Inflammation and Bile Accumulation via Activation of PPARα

Frontiers in Pharmacology, 2022
Cholestasis is caused by intrahepatic retention of excessive toxic bile acids and ultimately results in hepatic failure. Da-Chai-Hu-Tang (DCHT) has been used in China to treat liver and gallbladder diseases for over 1800 years. Here, we demonstrated that
Shihao Xu, Xi Qiao, Peike Peng, Ziyi Zhu, Yaoting Li, Yaoting Li, Mengyuan Yu, Mengyuan Yu, Long Chen, Yin Cai, Jin Xu, Xinwei Shi, Christopher G. Proud, Christopher G. Proud, Jianling Xie, Jianling Xie, Kaikai Shen   +16 more
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Perinatal outcomes of intrahepatic cholestasis during pregnancy: An 8-year case-control study.

PLoS ONE, 2020
INTRODUCTION:Previous studies of fetal effects have suggested that intrahepatic cholestasis of pregnancy is associated with a higher rate of adverse neonatal outcomes including preterm birth, neonatal respiratory distress syndrome, meconium-stained ...
Chloé Arthuis, Caroline Diguisto, Henri Lorphelin, Vincent Dochez, Emmanuel Simon, Franck Perrotin, Norbert Winer   +6 more
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Intrahepatic cholestasis of pregnancy [PDF]

РМЖ. Мать и дитя, 2019
P.V. Kozlov1, I.V. Samsonova2 1Pirogov Russian National Research Medical University, Moscow, Russian Federation 2City Clinical Hospital No. 52, Moscow, Russian Federation Intrahepatic cholestasis of pregnancy (ICP) is a reversible form of ...
P.V. Kozlov, I.V. Samsonova
doaj   +3 more sources

Congenital thrombophilia associated with intrahepatic cholestasis of pregnancy. A case report [PDF]

Folia Medica, 2022
Intrahepatic cholestasis of pregnancy is pregnancy-specific liver disorder, characterized by pruritus as the main clinical symptom, and fasting liver function tests.
Corina Iliadi-Tulbure, Maria Cemortan, Cristina Bubulici, Mihaela Botnari-Gutu, Olga Cernetchi   +4 more
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Gut microbiota alters host bile acid metabolism to contribute to intrahepatic cholestasis of pregnancy

Nature Communications, 2023
Intrahepatic cholestasis of pregnancy (ICP) is a female pregnancy-specific disorder that is characterized by increased serum bile acid and adverse fetal outcomes.
Bo Tang, Li Tang, Sheng-Yang Li, Shuang Liu, Jialin He, Pan Li, Sumin Wang, Min Yang, Longhui Zhang, Yuanyuan Lei, Dianji Tu, Xuefeng Tang, Hua Hu, Q. Ouyang, Xia Chen, Shiming Yang   +15 more
semanticscholar   +1 more source

Distribution of endotoxin in maternal and fetal body with intrahepatic cholestasis of pregnancy and its association with adverse fetal outcome

BMC Pregnancy and Childbirth, 2022
Background Intrahepatic cholestasis of pregnancy is a pregnancy-specific liver disease. In this study, we sought to explore the distribution of lipopolysaccharide in the maternal body, and its effect on the fetal body in the intrahepatic cholestasis of ...
Xiaomei Huang, Lei Lei, Fan Feng, Yong Shao   +3 more
doaj   +1 more source

GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements

Nature Communications, 2022
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder affecting 0.5–2% of pregnancies. The majority of cases present in the third trimester with pruritus, elevated serum bile acids and abnormal serum liver tests.
P. Dixon, A. Levine, Inês Cebola, M. Chan, Aliya S Amin, Anshul Aich, M. Mozere, Hannah Maude, Alice L. Mitchell, Jun Zhang, J. Chambers, A. Syngelaki, J. Donnelly, S. Cooley, M. Geary, Kypros Nicolaides, M. Thorsell, W. Hague, M. Estiù, H. Marschall, D. Gale, C. Williamson   +21 more
semanticscholar   +1 more source

Extrahepatic manifestations of progressive familial intrahepatic cholestasis syndromes: Presentation of a case series and literature review

Liver international (Print), 2022
Progressive familial intrahepatic cholestasis (PFIC) is a collective term for a heterogenous group of rare, inherited cholestasis syndromes. The number of genes underlying the clinical PFIC phenotype is still increasing.
E. Pfister, C. Dröge, R. Liebe, Amelie Stalke, Nicole Buhl, A. Ballauff, T. Cantz, E. Bueltmann, J. Stindt, Tom Luedde, U. Baumann, V. Keitel   +11 more
semanticscholar   +1 more source

Bile Acids in Intrahepatic Cholestasis of Pregnancy

Diagnostics, 2022
Intrahepatic cholestasis of pregnancy (ICP) is the most common, reversible, and closely related to pregnancy condition characterized by elevated levels of bile acids (BAs) in blood serum and an increased risk of adverse perinatal outcomes.
Maciej Majsterek, Magdalena Wierzchowska-Opoka, Inga Makosz, L. Kreczyńska, Ż. Kimber-Trojnar, B. Leszczyńska-Gorzelak   +5 more
semanticscholar   +1 more source

A novel homozygous mutation in the USP53 gene as the cause of benign recurrent intrahepatic cholestasis in children: a case report

The Turkish Journal of Pediatrics, 2023
Background. Benign recurrent intrahepatic cholestasis (BRIC) is a rare cause of cholestasis with recurrent episodes of jaundice and pruritus without extrahepatic bile duct obstruction.
Burcu Berberoğlu Ateş, Ahmet Cevdet Ceylan, Gülin Hızal, Fatih Duran, Hayriye Tatlı Doğan, Şamil Hızlı   +5 more
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