Results 111 to 120 of about 51,796 (192)

Are Postprandial Bile Acid Levels Helpful in Predicting Perinatal Complications in Patients with Intrahepatic Cholestasis of Pregnancy?

Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2015
Purpose: To determine the outcomes of Iintrahepatic cholestasis of pregnancy and the role of postprandial serum bile acid levels in the prediction of perinatal complications.
Kudret Erkenekli, Can Tekin iskender, Hasan Onur Topcu, Tugba Ensari, Dilek Uygur, Nuri Danisman   +5 more
doaj  

Gallstone formation and hepatobiliary tumour risk: Clinical implications of the bile acid–gut microbiota axis

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
1. Irregular dietary patterns (e.g., late breakfast, reduced meal frequency) upregulate the bai gene cluster by disrupting cholecystokinin (CCK) release rhythms and gut microbiota circadian rhythms, leading to increased production of secondary bile acids, particularly DCA. High‐carbohydrate dietary patterns increase gallstone risk (OR = 1.329).
Rui Li, Yong Zhang, Kaishuang Cai, Shaojun Deng, Chaofeng Tan, Yunjie Li, Wenjin Liang   +6 more
wiley   +1 more source

When Liver Disease Misleads the Diagnosis: Two Cases of TAFRO Syndrome With Porto‐Sinusoidal Vascular Disease

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Background TAFRO syndrome is a rare inflammatory disorder whose hepatic manifestations may mimic decompensated cirrhosis. Cases: We report two women with TAFRO syndrome associated with portal‐sinusoidal vascular disorder (PSVD), a rare cause of non‐cirrhotic portal hypertension. In both cases, liver biopsy excluded cirrhosis and confirmed PSVD.
Laura Dassy, Fanny Poletti, Kaoutar Hafraoui, Marie Lejeune, Joan Somja, Patrick Collins, Julien Guiot, Ivan Theate, Jo Caers, Jean Delwaide, Astrid Marot, Virginie Putzeys, Gaëlle Vertenoeil   +12 more
wiley   +1 more source

Drug‐Induced Liver Injury During Treatment With Tocilizumab: A Case Report of an Atypical Pattern Lesion

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Tocilizumab is an interleukin‐6 (IL‐6) receptor antagonist indicated for various rheumatologic conditions. While hepatotoxicity is a recognized adverse effect, it predominantly manifests as hepatocellular injury. We report a rare case of drug‐induced liver injury (DILI) presenting with a cholestatic pattern and cholangitis features in a 75 ...
Louis‐Edmond Barbaro, Nouha Ben Othman, Delphine Viard, Fanny Rocher, Elliot Ewig, Raja Mroue, Claire Amigues, Alexandre O. Gérard   +7 more
wiley   +1 more source

The association between intrahepatic cholestasis of pregnancy and neurodevelopmental conditions after excluding those with intrahepatic cholestasis of pregnancy diagnosed at delivery and after excluding those born prematurely.

The association between intrahepatic cholestasis of pregnancy and neurodevelopmental conditions after excluding those with intrahepatic cholestasis of pregnancy diagnosed at delivery and after excluding those born prematurely.
Renee M. Gardner (12693008), Viktor H. Ahlqvist (8098283), Hugo Sjöqvist (12082084), Olof Stephansson (119785), Cecilia Magnusson (159189), Christina Dalman (159195), Shuyun Chen (542563), Brian K. Lee (9676862), Håkan Karlsson (6172049)   +8 more
core   +1 more source

Long‐Term Safety and Efficacy of Obeticholic Acid in Patients With Primary Biliary Cholangitis: Final Results of the POISE Long‐Term Safety Extension

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 8, Page 1083-1096, October 2026.
In the POISE open‐label extension, patients with primary biliary cholangitis with inadequate response or intolerance to ursodeoxycholic acid received long‐term obeticholic acid (OCA) treatment. Findings demonstrated a safety profile consistent with the known characteristics of OCA, with no unexpected safety signals, while supporting sustained efficacy ...
Christopher L. Bowlus, Frederik Nevens, Kris V. Kowdley, Alan Bonder, Thomas Capozza, Jing Li, Radhika Nair, Michael Trauner, David E. Jones   +8 more
wiley   +1 more source

The association between maternal intrahepatic cholestasis and different offspring neurodevelopmental conditions, stratified by the gestational period of onset of intrahepatic cholestasis.

The association between maternal intrahepatic cholestasis and different offspring neurodevelopmental conditions, stratified by the gestational period of onset of intrahepatic cholestasis.
Renee M. Gardner (12693008), Viktor H. Ahlqvist (8098283), Hugo Sjöqvist (12082084), Olof Stephansson (119785), Cecilia Magnusson (159189), Christina Dalman (159195), Shuyun Chen (542563), Brian K. Lee (9676862), Håkan Karlsson (6172049)   +8 more
core   +1 more source

Baseline and Longitudinal Liver Stiffness Measurement Predict Outcomes in Primary Biliary Cholangitis: A Multicenter Study

Hepatology Research, Volume 56, Issue 10, Page 1524-1534, October 2026.
We conducted a multicenter cohort study analyzed 454 Japanese PBC patients. Baseline LSM ≥ 8.0 kPa was independently associated with adverse outcomes. ΔLSM/year ≥ 2.1 kPa was independently associated with adverse outcomes. ABSTRACT Background & Aims Liver stiffness measurement (LSM) using vibration‐controlled transient elastography (VCTE) is a ...
Yuki Yamashita, Takefumi Kimura, Kaede Fujita, Taiki Okumura, Takanobu Iwadare, Hiroyuki Kobayashi, Shun‐ichi Wakabayashi, Tomoo Yamazaki, Satoru Joshita, Takeji Umemura, Masanori Abe, Akinobu Takaki, Kazumichi Abe, Masaaki Takamura, Tadashi Namisaki, Yuki Kugiyama, Atsumasa Komori, Atsushi Tanaka   +17 more
wiley   +1 more source

Progressive Familial Intrahepatic Cholestasis Type 1

, 2010
Progressive familial intrahepatic cholestasis type 1 is a rare genetic liver disease that presents in the first year of life. Bile salts are elevated and these patients are often jaundiced.
Jansen, Peter L. M., Oude Elferink, Ronald P. J., Paulusma, Coen C.   +2 more
core   +1 more source

Inhibition of Calcium‐Sensing Receptor Suppresses Malignant Behaviours of Human Hepatocellular Carcinoma

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Hepatocellular carcinoma (HCC) continues to pose significant worldwide health burdens due to restricted treatment alternatives and unfavourable prognosis. This investigation reveals the pivotal involvement of calcium‐sensing receptor (CaSR) in HCC advancement and its potential as a promising therapeutic target. Through pharmacological blockade
Tingting Liu, Wei Xu, Qianqian Gao, N. Ngwa Adeline, Qi Yang, Dawei He, Yukai Tao, Jun Sun, Jie Gu, Haifeng Shi, Michael Aschner, Yang Ye, Jian Chen, Rongzhu Lu   +13 more
wiley   +1 more source